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UMC Repository: Recent submissions

  • The Clinical Toxicology of 4-Bromo-2,5-dimethoxyphenethylamine (2C-B): The Severity of Poisoning After Exposure to Low to Moderate and High Doses 
    Nugteren-van Lonkhuyzen, Johanna J; de Lange, Dylan W; van Riel, Antoinette J H P; Vrolijk, Ruben Q; Ohana, Dana; Hondebrink, Laura (Mosby Inc., 2020-09)
    STUDY OBJECTIVE: We studied the severity of poisoning after exposure to low to moderate and high doses of 4-bromo-2,5-dimethoxyphenethylamine (2C-B). METHODS: Patients for whom the Dutch Poisons Information Centre was ...
  • Should we deny ICU admission to the elderly?: Ethical considerations in times of COVID-19 
    Haas, Lenneke E M; de Lange, Dylan W; van Dijk, Diederik; van Delden, Johannes J M (Springer Science + Business Media, 2020-06-09)
  • The performance of acute versus antecedent patient characteristics for 1-year mortality prediction during intensive care unit admission: a national cohort study 
    Kerckhoffs, Monika C; Brinkman, Sylvia; de Keizer, Nicolet; Soliman, Ivo W; de Lange, Dylan W; van Delden, Johannes J M; van Dijk, Diederik (Springer Science + Business Media, 2020-06-11)
    Background: Multiple factors contribute to mortality after ICU, but it is unclear how the predictive value of these factors changes during ICU admission. We aimed to compare the changing performance over time of the acute ...
  • The association between influenza infections in primary care and intensive care admissions for severe acute respiratory infection (SARI): A modelling approach 
    van Asten, Liselotte; Luna Pinzon, Angie; van de Kassteele, Jan; Donker, Gé; de Lange, Dylan W; Dongelmans, Dave A; de Keizer, Nicolette F; van der Hoek, Wim (Wiley-Blackwell, 2020-09-01)
    BACKGROUND: The burden of severe influenza virus infections is poorly known, for which surveillance of severe acute respiratory infection (SARI) is encouraged. Hospitalized SARI patients are however not always tested for ...
  • Laparoscopic based renal denervation in a canine neurogenic hypertension model 
    Shao, Chunlai; Zhou, Yan; You, Tao; Xue, Boxin; Stella, Pieter R; Jiang, Ting Bo; Miao, Zhigang; Xu, Longjiang; Yin, X.; Lan, Longsheng; Rong, Guang (BioMed Central, 2020-06-11)
    Background: Previous renal denervation (RDN) studies showed controversial results in reducing blood pressure. The aim of this study was to provide evidence supporting the effectiveness of laparoscopic-based renal denervation ...
  • Recurrent Loss of SMARCA4 in Sinonasal Teratocarcinosarcoma 
    Rooper, Lisa M; Uddin, Nasir; Gagan, Jeffrey; Brosens, Lodewijk A A; Magliocca, Kelly R; Edgar, Mark A; Thompson, Lester D R; Agaimy, Abbas; Bishop, Justin A (Lippincott Williams & Wilkins, 2020-10)
    Molecular analysis has reshaped the landscape of high grade sinonasal tumors by defining novel entities and identifying recurrent mutations in established tumor types. However, sinonasal teratocarcinosarcoma (TCS), a rare ...
  • Thirty-six-year-old woman with a liver mass: diagnosis hidden in history 
    Vos, Shoko; Kamphuis, Anna M; Brosens, Lodewijk A A (BMJ Publishing Group, 2020-12-01)
  • Endocrine Cephalic Phase Responses to Food Cues: A Systematic Review 
    Lasschuijt, Marlou P; Mars, Monica; de Graaf, Cees; Smeets, Paul A M (Elsevier, 2020-09-15)
    Cephalic phase responses (CPRs) are conditioned anticipatory physiological responses to food cues. They occur before nutrient absorption and are hypothesized to be important for satiation and glucose homeostasis. Cephalic ...
  • The Predictive Validity of Machine Learning Models in the Classification and Treatment of Major Depressive Disorder: State of the Art and Future Directions 
    Ermers, Nick J.; Hagoort, Karin; Scheepers, Floortje E. (Frontiers Research Foundation, 2020-05-25)
    Major depressive disorder imposes a substantial disease burden worldwide, ranking as the third leading contributor to global disability. In spite of its ubiquity, classifying and treating depression has proven troublesome. ...
  • Parental perspectives on care for sleep in children with cerebral palsy: a wake-up call 
    Hulst, Raquel Y; Voorman, Jeanine M; Pillen, Sigrid; Ketelaar, Marjolijn; Visser-Meily, Johanna M A; Verschuren, Olaf (Informa Healthcare, 2022-01-30)
    Purpose: Sleep problems are common in children with cerebral palsy (CP) and have a large impact on child health and family functioning. This qualitative study aimed to explore parental perspectives regarding the care for ...
  • Sleep slow wave homeostasis and cognitive functioning in children with electrical status epilepticus in sleep 
    van den Munckhof, Bart; Gefferie, Silvano R; van Noort, Suus A M; van Teeseling, Heleen C; Schijvens, Mischa P; Smit, William; Teunissen, Nico W; Plate, Joost D J; Huiskamp, Geert Jan M; Leijten, Frans S S; Braun, Kees P J; Jansen, Floor E; Bölsterli, Bigna K (Oxford University Press, 2020-11-01)
    Study Objectives: Encephalopathy with electrical status epilepticus in sleep (ESES) is characterized by non-rapid eye movement (non-REM)-sleep-induced epileptiform activity and acquired cognitive deficits. The synaptic ...
  • Collodion babies: a 15-year retrospective multicenter study in the Netherlands. Evaluation of severity scores to predict the underlying disease 
    Cuperus, E; Bolling, M C; de Graaf, M; van den Akker, P C; van Gijn, M E; Simon, M E H; Sigurdsson, V; Pasmans, S G M A (Mosby Inc., 2021-04)
  • Increasing Fusion Rate Between 1 and 2 Years After Instrumented Posterolateral Spinal Fusion and the Role of Bone Grafting 
    Dutch Clinical Spine Research Group (Lippincott Williams & Wilkins, 2020-10-15)
    Study Design.Two-year clinical and radiographic follow-up of a double-blind, multicenter, randomized, intra-patient controlled, non-inferiority trial comparing a bone graft substitute (AttraX ®Putty) with autograft in ...
  • von Willebrand Factor and Factor VIII Clearance in Perioperative Hemophilia A Patients 
    van Moort, Iris; Bukkems, Laura H; Heijdra, Jessica M; Schutgens, Roger E G; Laros-van Gorkom, Britta A P; Nieuwenhuizen, Laurens; van der Meer, Felix J M; Fijnvandraat, Karin; Ypma, Paula; de Maat, Moniek P M; Leebeek, Frank W G; Meijer, Karina; Eikenboom, Jeroen; Mathôt, Ron A A; Cnossen, Marjon H; “OPTI-CLOT” study group (Schattauer GmbH, 2020-07-01)
    Background von Willebrand factor (VWF) is crucial for optimal dosing of factor VIII (FVIII) concentrate in hemophilia A patients as it protects FVIII from premature clearance. To date, it is unknown how VWF behaves and ...
  • Prevalence of Food Sensitization and Food Allergy in Children across Europe 
    Lyons, Sarah A; Clausen, Michael; Knulst, André C; Ballmer-Weber, Barbara K; Fernandez-Rivas, Montserrat; Barreales, Laura; Bieli, Christian; Dubakiene, Ruta; Fernandez-Perez, Cristina; Jedrzejczak-Czechowicz, Monika; Kowalski, Marek L; Kralimarkova, Tanya; Kummeling, Ischa; Mustakov, Tihomir B; Papadopoulos, Nikolaos G; Popov, Todor A; Xepapadaki, Paraskevi; Welsing, Paco M J; Potts, James; Mills, E N Clare; van Ree, Ronald; Burney, Peter G J; Le, Thuy-My (2020-09)
    Background: For adults, prevalence estimates of food sensitization (FS) and food allergy (FA) have been obtained in a standardized manner across Europe. For children, such estimates are lacking. Objectives: To determine ...
  • Reintroduction failure after negative food challenges in adults is common and mainly due to atypical symptoms 
    Versluis, Astrid; Knulst, André C; van Erp, Francine C; Blankestijn, Mark A; Meijer, Yolanda; Le, Thuy-My; van Os-Medendorp, Harmieke (Wiley-Blackwell, 2020-04)
    BACKGROUND: Reintroduction of a food after negative food challenge (FC) faces many obstacles. There are no studies available about this subject in adults. OBJECTIVE: To investigate the frequency, reasons and risk factors ...
  • Predictors of Food Sensitization in Children and Adults across Europe 
    Lyons, Sarah A; Knulst, André C; Burney, Peter G J; Fernández-Rivas, Montserrat; Ballmer-Weber, Barbara K; Barreales, Laura; Bieli, Christian; Clausen, Michael; Dubakiene, Ruta; Fernández-Perez, Cristina; Jedrzejczak-Czechowicz, Monika; Kowalski, Marek L; Kummeling, Ischa; Mustakov, Tihomir B; van Os-Medendorp, Harmieke; Papadopoulos, Nikolaos G; Popov, Todor A; Potts, James; Xepapadaki, Paraskevi; Welsing, Paco M J; Mills, E N Clare; van Ree, Ronald; Le, Thuy-My (2020-10)
    Background: The geographical variation and temporal increase in the prevalence of food sensitization (FS) suggest environmental influences. Objective: To investigate how environment, infant diet, and demographic characteristics, ...
  • The importance of swelling for in vitro gastric digestion of whey protein gels 
    Deng, Ruoxuan; Mars, Monica; Van Der Sman, Ruud G.M.; Smeets, Paul A.M.; Janssen, Anja E.M. (Elsevier Limited, 2020-11-15)
    In this paper we report the importance of swelling on gastric digestion of protein gels, which is rarely recognized in literature. Whey protein gels with NaCl concentrations 0–0.1 M were used as model foods. The Young's ...
  • CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank 
    Geurts, Maarten H.; de Poel, Eyleen; Amatngalim, Gimano D.; Oka, Rurika; Meijers, Fleur M.; Kruisselbrink, Evelien; van Mourik, Peter; Berkers, Gitte; de Winter-de Groot, Karin M.; Michel, Sabine; Muilwijk, Danya; Aalbers, Bente L.; Mullenders, Jasper; Boj, Sylvia F.; Suen, Sylvia W.F.; Brunsveld, Jesse E.; Janssens, Hettie M.; Mall, Marcus A.; Graeber, Simon Y.; van Boxtel, Ruben; van der Ent, Cornelis K.; Beekman, Jeffrey M.; Clevers, Hans (Cell Press, 2020-04-02)
    Adenine base editing (ABE) enables enzymatic conversion from A-T into G-C base pairs. ABE holds promise for clinical application, as it does not depend on the introduction of double-strand breaks, contrary to conventional ...
  • Structural basis of semaphorin-plexin cis interaction 
    Rozbesky, Daniel; Verhagen, Marieke G.; Karia, Dimple; Nagy, Gergely N.; Alvarez, Luis; Robinson, Ross A.; Harlos, Karl; Padilla-Parra, Sergi; Pasterkamp, R. Jeroen; Jones, Edith Yvonne (Springer Science and Business Media Deutschland GmbH, 2020-07-01)
    Semaphorin ligands interact with plexin receptors to contribute to functions in the development of myriad tissues including neurite guidance and synaptic organisation within the nervous system. Cell-attached semaphorins ...