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UMC Repository: Recent submissions

  • Prior distributions for variance parameters in a sparse-event meta-analysis of a few small trials 
    Pateras, Konstantinos; Nikolakopoulos, Stavros; Roes, Kit C.B. (John Wiley & Sons Inc., 2021-01-01)
    In rare diseases, typically only a small number of patients are available for a randomized clinical trial. Nevertheless, it is not uncommon that more than one study is performed to evaluate a (new) treatment. Scarcity of ...
  • Understanding the essential components and experiences of youth with autism spectrum disorders in peer mentorship programmes during the transition to adulthood: a qualitative meta-ethnography 
    Nguyen, Linda; Jack, Susan; Ketelaar, Marjolijn; Di Rezze, Briano; Soper, Alice Kelen; Gorter, Jan Willem (Wiley-Blackwell, 2020-11)
    Youth with an autism spectrum disorder (ASD) often require additional supports during the period of transition to from high school to post-secondary education or career paths. Peer mentorship (PM) programmes create ...
  • SOX10 is as specific as S100 protein in detecting metastases of melanoma in lymph nodes and is recommended for sentinel lymph node assessment 
    EORTC Melanoma Group (Elsevier Limited, 2020-09)
    BACKGROUND: Sentinel lymph node (SLN) biopsy remains crucial for melanoma staging. The European Organisation for Research and Treatment of Cancer Melanoma Group recommends performing immunohistochemical stainings for ...
  • Association of Factor V Leiden With Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data 
    Mahmoodi, Bakhtawar K; Tragante, Vinicius; Kleber, Marcus E; Holmes, Michael V; Schmidt, Amand F; McCubrey, Raymond O; Howe, Laurence J; Direk, Kenan; Allayee, Hooman; Baranova, Ekaterina V; Braund, Peter S; Delgado, Graciela E; Eriksson, Niclas; Gijsberts, Crystel M; Gong, Yan; Hartiala, Jaana; Heydarpour, Mahyar; Pasterkamp, Gerard; Kotti, Salma; Kuukasjärvi, Pekka; Lenzini, Petra A; Levin, Daniel; Lyytikäinen, Leo-Pekka; Muehlschlegel, Jochen D; Nelson, Christopher P; Nikus, Kjell; Pilbrow, Anna P; Wilson Tang, W H; van der Laan, Sander W; van Setten, Jessica; Vilmundarson, Ragnar O; Deanfield, John; Deloukas, Panos; Dudbridge, Frank; James, Stefan; Mordi, Ify R; Teren, Andrej; Bergmeijer, Thomas O; Body, Simon C; Bots, Michiel; Burkhardt, Ralph; Cooper-DeHoff, Rhonda M; Cresci, Sharon; Danchin, Nicolas; Doughty, Robert N; Grobbee, Diederick E; Hagström, Emil; Hazen, Stanley L; Held, Claes; Hoefer, Imo E; Hovingh, G Kees; Johnson, Julie A; Kaczor, Marcin P; Kähönen, Mika; Klungel, Olaf H; Laurikka, Jari O; Lehtimäki, Terho; Maitland-van der Zee, Anke H; McPherson, Ruth; Palmer, Colin N; Kraaijeveld, Adriaan O; Pepine, Carl J; Sanak, Marek; Sattar, Naveed; Scholz, Markus; Simon, Tabassome; Spertus, John A; Stewart, Alexandre F R; Szczeklik, Wojciech; Thiery, Joachim; Visseren, Frank L J; Waltenberger, Johannes; Richards, A Mark; Lang, Chim C; Cameron, Vicky A; Åkerblom, Axel; Pare, Guillaume; März, Winfried; Samani, Nilesh J; Hingorani, Aroon D; Ten Berg, Jurriën M; Wallentin, Lars; Asselbergs, Folkert W; Patel, Riyaz S (Lippincott Williams & Wilkins, 2020-08-11)
    BACKGROUND: Studies examining the role of factor V Leiden among patients at higher risk of atherothrombotic events, such as those with established coronary heart disease (CHD), are lacking. Given that coagulation is involved ...
  • Predicting recurrence in patients with sentinel node-negative melanoma: validation of the EORTC nomogram using population-based data 
    El Sharouni, M A; Ahmed, T; Witkamp, A J; Sigurdsson, V; van Gils, C H; Nieweg, O E; Scolyer, R A; Thompson, J F; van Diest, P J; Lo, S N (John Wiley & Sons Inc., 2021-05)
    BACKGROUND: Identifying patients with sentinel node (SN)-negative melanoma who are at greatest risk of recurrence is important. The European Organization for Research and Treatment of Cancer (EORTC) Melanoma Group proposed ...
  • Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: a Retrospective Cohort Study 
    Moorlag, Simone J C F M; van Deuren, Rosanne C; van Werkhoven, Cornelis H; Jaeger, Martin; Debisarun, Priya; Taks, Esther; Mourits, Vera P; Koeken, Valerie A C M; de Bree, L Charlotte J; Ten Doesschate, Thijs; Cleophas, Maartje C; Smeekens, Sanne; Oosting, Marije; van de Veerdonk, Frank L; Joosten, Leo A B; Ten Oever, Jaap; van der Meer, Jos W M; Curtis, Nigel; Aaby, Peter; Stabell-Benn, Christine; Giamarellos-Bourboulis, Evangelos J; Bonten, Marc; van Crevel, Reinout; Netea, Mihai G (Cell Press, 2020-08-25)
    Bacille Calmette-Guérin (BCG) induces long-term boosting of innate immunity, termed trained immunity, and decreases susceptibility to respiratory tract infections. BCG vaccination trials for reducing SARS-CoV-2 infection ...
  • The content validity of the items related to the social and spiritual dimensions of the Utrecht Symptom Diary - 4 Dimensional from a patient's perspective: a qualitative study 
    de Vries, Sita; Lormans, Tom; de Graaf, Everlien; Leget, Carlo; Teunissen, Saskia (Elsevier, 2021-02)
    Context: In palliative care, caregivers often lack words and competences to discuss patients' needs in social and spiritual dimensions. The Utrecht Symptom Diary-4 Dimensional (USD-4D) is an instrument that can be used to ...
  • Validation of an algorithm for semiautomated surveillance to detect deep surgical site infections after primary total hip or knee arthroplasty-A multicenter study 
    Verberk, Janneke D M; van Rooden, Stephanie M; Koek, Mayke B G; Hetem, David J; Smilde, Annelies E; Bril, Wendy S; Streefkerk, Roel H R A; Hopmans, Titia E M; Bonten, Marc J M; de Greeff, Sabine C; van Mourik, Maaike S M (Cambridge University Press, 2021-01)
    OBJECTIVE: Surveillance of healthcare-associated infections is often performed by manual chart review. Semiautomated surveillance may substantially reduce workload and subjective data interpretation. We assessed the validity ...
  • Preimplantation genetic testing for monogenic kidney disease 
    Snoek, Rozemarijn; Stokman, Marijn F; Lichtenbelt, Klaske D; van Tilborg, Theodora C; Simcox, Cindy E; Paulussen, Aimée D C; Dreesen, Jos C M F; van Reekum, Franka; Lely, A Titia; Knoers, Nine V A M; de Die-Smulders, Christine E M; van Eerde, Albertien M (Lippincott Williams & Wilkins, 2020-09-07)
    Background and objectives A genetic cause can be identified for an increasing number of pediatric and adult-onset kidney diseases. Preimplantation genetic testing (formerly known as preimplantation genetic diagnostics) is ...
  • Oxidative stress and endothelial dysfunction are associated with reduced cognition in type 2 diabetes 
    Groeneveld, Onno N.; van den Berg, Esther; Johansen, Odd Erik; Schnaidt, Sven; Hermansson, Karin; Zinman, Bernard; Espeland, Mark A.; Biessels, Geert Jan (SAGE Publications Ltd, 2019-11-01)
    Objective: Type 2 diabetes is associated with cognitive dysfunction, but the mechanisms are unknown. We assessed the relationships of biomarkers of oxidation, endothelial function and inflammation with cognition in ...
  • High occurrence of impaired emotion recognition after ischemic stroke 
    on behalf of the PROCRAS study group (SAGE Publications Inc., 2020-09)
    Introduction: Deficits of emotion recognition after ischemic stroke are often overlooked by clinicians, and are mostly not spontaneously reported by patients. However, impaired emotion recognition after stroke negatively ...
  • Cerebral blood flow and cognitive functioning in patients with disorders along the heart–brain axis: Cerebral blood flow and the heart–brain axis 
    Heart-Brain Connection Consortium (Wiley, 2020)
    Introduction: We examined the role of hemodynamic dysfunction in cognition by relating cerebral blood flow (CBF), measured with arterial spin labeling (ASL), to cognitive functioning, in patients with heart failure (HF), ...
  • High blood pressure predicts hippocampal atrophy rate in cognitively impaired elders 
    Fiford, Cassidy M; Nicholas, Jennifer M; Biessels, Geert Jan; Lane, Christopher A; Cardoso, M Jorge; Barnes, Josephine (John Wiley & Sons Inc., 2020)
    Introduction: Understanding relationships among blood pressure (BP), cognition, and brain volume could inform Alzheimer's disease (AD) management. Methods: We investigated Alzheimer's Disease Neuroimaging Initiative (ADNI) ...
  • A first lead in dementia prevention in people with diabetes 
    Biessels, Geert Jan (Elsevier Limited, 2020-07)
  • Absence of an infarct on MRI is not uncommon after clinical diagnosis of ischemic stroke 
    Procras Study Group (W.B. Saunders, 2020-08)
    INTRODUCTION: An infarct on brain MRI is often seen as gold standard when diagnosing ischemic stroke. Although MRI has high sensitivity in detecting a lesion shortly after ischemic stroke, this rapidly declines when time ...
  • Small vessel disease lesion type and brain atrophy: The role of co-occurring amyloid 
    Heinen, Rutger; Groeneveld, Onno N; Barkhof, Frederik; de Bresser, Jeroen; Exalto, Lieza G; Kuijf, Hugo J; Prins, Niels D; Scheltens, Philip; van der Flier, Wiesje M; Biessels, Geert Jan; TRACE‐VCI study group (John Wiley & Sons Inc., 2020)
    Introduction: It is unknown whether different types of small vessel disease (SVD), differentially relate to brain atrophy and if co-occurring Alzheimer's disease pathology affects this relation. Methods: In 725 memory ...
  • Diabetes-specific dementia risk score (DSDRS) predicts cognitive performance in patients with type 2 diabetes at high cardio-renal risk 
    Verhagen, Chloë; Janssen, Jolien; Exalto, Lieza G; van den Berg, Esther; Johansen, Odd Erik; Biessels, Geert Jan (Elsevier, 2020-10)
    Aim: To investigate the relationship between the diabetes-specific dementia risk score (DSDRS) and concurrent and future cognitive impairment (CI) in type 2 diabetes (T2D). Methods: DSDRS were calculated for participants ...
  • Prediction of poor clinical outcome in vascular cognitive impairment: TRACE-VCI study 
    TRACE‐VCI study group (John Wiley & Sons Inc., 2020)
    Introduction: Prognostication in memory clinic patients with vascular brain injury (eg possible vascular cognitive impairment [VCI]) is often uncertain. We created a risk score to predict poor clinical outcome. Methods: ...
  • Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future 
    Mok, Vincent C T; Pendlebury, Sarah; Wong, Adrian; Alladi, Suvarna; Au, Lisa; Bath, Philip M; Biessels, Geert Jan; Chen, Christopher; Cordonnier, Charlotte; Dichgans, Martin; Dominguez, Jacqueline; Gorelick, Philip B; Kim, SangYun; Kwok, Timothy; Greenberg, Steven M; Jia, Jianping; Kalaria, Rajesh; Kivipelto, Miia; Naegandran, Kandiah; Lam, Linda C W; Lam, Bonnie Yin Ka; Lee, Allen T C; Markus, Hugh S; O'Brien, John; Pai, Ming-Chyi; Pantoni, Leonardo; Sachdev, Perminder; Skoog, Ingmar; Smith, Eric E; Srikanth, Velandai; Suh, Guk-Hee; Wardlaw, Joanna; Ko, Ho; Black, Sandra E; Scheltens, Philip (John Wiley & Sons Inc., 2020-11)
    We have provided an overview on the profound impact of COVID-19 upon older people with Alzheimer's disease and other dementias and the challenges encountered in our management of dementia in different health-care settings, ...
  • Automated Assessment of Cerebral Arterial Perforator Function on 7T MRI 
    Arts, Tine; Siero, Jeroen C W; Biessels, Geert Jan; Zwanenburg, Jaco J M (John Wiley & Sons Inc., 2021-01)
    BACKGROUND: Blood flow velocity and pulsatility of small cerebral perforating arteries can be measured using 7T quantitative 2D phase contrast (PC) MRI. However, ghosting artifacts arising from subject movement and pulsating ...