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Now showing items 18241-18260 of 40729

Scale-up integrated care for diabetes and hypertension in Cambodia, Slovenia and Belgium (SCUBY): a study design for a quasi-experimental multiple case study

the SCUBY Consortium (Taylor and Francis Ltd., 2020-12-31)

Health systems worldwide struggle to manage the growing burden of type 2 diabetes and hypertension. Many patients receive suboptimal care, especially those most vulnerable. An evidence-based Integrated Care Package (ICP) ...
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

Nikolaev, Mikhail; Mitrofanova, Olga; Broguiere, Nicolas; Geraldo, Sara; Dutta, Devanjali; Tabata, Yoji; Elci, Bilge; Brandenberg, Nathalie; Kolotuev, Irina; Gjorevski, Nikolce; Clevers, Hans; Lutolf, Matthias P. (Nature Research, 2020-09-24)

Epithelial organoids, such as those derived from stem cells of the intestine, have great potential for modelling tissue and disease biology1–4. However, the approaches that are used at present to derive these organoids in ...
Zebrafish prrx1a mutants have normal hearts

Tessadori, Federico; de Bakker, Dennis E.M.; Barske, Lindsey; Nelson, Nellie; Algra, Hermine A.; Willekers, Sven; Nichols, James T.; Crump, J. Gage; Bakkers, Jeroen (Nature Research, 2020-09-24)
Muscle defects due to perturbed somite segmentation contribute to late adult scoliosis

Lleras-Forero, Laura; Newham, Elis; Teufel, Stefan; Kawakami, Koichi; Hartmann, Christine; Hammond, Chrissy L.; Knight, Robert D.; Schulte-Merker, Stefan (US Administration on Aging, 2020-09-30)

Scoliosis is an abnormal bending of the body axis. Truncated vertebrae or a debilitated ability to control the musculature in the back can cause this condition, but in most cases the causative reason for scoliosis is unknown ...
Establishment of patient-derived cancer organoids for drug-screening applications

Driehuis, Else; Kretzschmar, Kai; Clevers, Hans (Springer Nature, 2020-10-01)

Adult stem cell–based organoid technology is a versatile tool for the generation and long-term maintenance of near-native 3D epithelial tissues in vitro. The generation of cancer organoids from primary patient material ...
A Biosensor for the Mitotic Kinase MPS1 Reveals Spatiotemporal Activity Dynamics and Regulation

Kuijt, Timo E.F.; Lambers, Maaike L.A.; Weterings, Sonja; Ponsioen, Bas; Bolhaqueiro, Ana C.F.; Staijen, Debbie H.M.; Kops, Geert J.P.L. (Cell Press, 2020-10-05)

Accurate chromosome segregation during cell division critically depends on error correction of chromosome-spindle interactions and the spindle assembly checkpoint (SAC) [1–3]. The kinase MPS1 is an essential regulator of ...
Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss

Morkmued, Supawich; Clauss, François; Schuhbaur, Brigitte; Fraulob, Valérie; Mathieu, Eric; Hemmerlé, Joseph; Clevers, Hans; Koo, Bon Kyoung; Dollé, Pascal; Bloch-Zupan, Agnès; Niederreither, Karen (Nature Publishing Group, 2020-09-09)

Secreted extracellular matrix components which regulate craniofacial development could be reactivated and play roles in adult wound healing. We report a patient with a loss-of-function of the secreted matricellular protein ...
Author Correction: The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unresponsive to standard heart failure therapy (vol 10, 9819, 2020): The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unresponsive to standard heart failure therapy

Eijgenraam, Tim R.; Boukens, Bastiaan J.; Boogerd, Cornelis J.; Schouten, E. Marloes; van de Kolk, Cees W.A.; Stege, Nienke M.; te Rijdt, Wouter P.; Hoorntje, Edgar T.; van der Zwaag, Paul A.; van Rooij, Eva; van Tintelen, J. Peter; van den Berg, Maarten P.; van der Meer, Peter; van der Velden, Jolanda; Silljé, Herman H.W.; de Boer, Rudolf A. (Nature Publishing Group, 2020-10-02)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Hepatocyte growth factor/MET and CD44 in colorectal cancer: partners in tumorigenesis and therapy resistance

Joosten, Sander P.J.; Spaargaren, Marcel; Clevers, Hans; Pals, Steven T. (Elsevier, 2020-12)

Intestinal epithelial self-renewal is a tightly controlled process, which is critically dependent on WNT signalling. Aberrant activation of the WNT pathway in intestinal stem cells (ISCs) results in constitutive transcription ...
Do age and comorbidity impair recovery during two years after treatment for endometrial cancer?

van Walree, Inez C; Hamaker, Marije E; de Rooij, Belle H; Boll, Dorry; van Huis-Tanja, Lieke H; Emmelot-Vonk, Marielle H; Ezendam, Nicole P M (Elsevier, 2020-09)

BACKGROUND: A better understanding of the impact of age and comorbidity on health-related quality of life (HRQoL) may improve treatment decision-making in patients with endometrial cancer. We investigated whether either ...
Masticatory performance and oral health-related quality of life in edentulous maxillectomy patients: A cross-sectional study to compare implant-supported obturators and conventional obturators

Buurman, Doke J M; Speksnijder, Caroline M; Engelen, Britt H B T; Kessler, Peter (Blackwell Munksgaard, 2020-05)

OBJECTIVE: The aim of this cross-sectional study was to compare the masticatory performance and oral health-related quality of life (OHRQoL) of edentulous maxillectomy patients with and without implant-supported obturator ...
Distance control and virtual drilling improves anatomical orientation during anterior petrosectomy

Voormolen, Eduard H.; Diederen, Sander; Cebula, Helene; Woerdeman, Peter A.; Jan Noordmans, Herke; Viergever, Max A.; Robe, Pierre A.; Froelich, Sebastien; Regli, Luca; Berkelbach, Jan Willem (Oxford University Press, 2020-01-01)

BACKGROUND: A combined drill distance control and virtual drilling image guidance feedback method was developed. OBJECTIVE: To investigate whether first-time usage of the proposed method, during anterior petrosectomy (AP), ...
Focal salvage treatment for radiorecurrent prostate cancer: A magnetic resonance-guided stereotactic body radiotherapy versus high-dose-rate brachytherapy planning study

Willigenburg, Thomas; Beld, Ellis; Hes, Jochem; Lagendijk, Jan J.W.; de Boer, Hans C.J.; Moerland, Marinus A.; van der Voort van Zyp, Jochem R.N. (Elsevier, 2020-07)

Background and Purpose: Magnetic resonance imaging (MRI)-guided focal salvage high-dose-rate brachytherapy (FS-HDR-BT) is one of the treatment options for radiorecurrent localized prostate cancer. However, due to the ...
Clinical judgment versus geriatric assessment for frailty in older patients with cancer

van Walree, Inez C; Scheepers, Ellen R M; van den Bos, Frederiek; van Huis-Tanja, Lieke H; Emmelot-Vonk, Marielle H; Hamaker, Marije E (Elsevier, 2020-09)

BACKGROUND: Geriatric assessment (GA) is an appropriate method for identifying frailty in older patients with cancer, but a shorter instrument may be easier to use in clinical practice. Clinical judgment is always available ...
Variation in antibiotic prescription rates in febrile children presenting to emergency departments across Europe (MOFICHE): A multicentre observational study

on behalf of the PERFORM consortium (Public Library of Science, 2020-08-19)

Background The prescription rate of antibiotics is high for febrile children visiting the emergency department (ED), contributing to antimicrobial resistance. Large studies at European EDs covering diversity in antibiotic ...
Live-attenuated Respiratory Syncytial Virus Vaccines: Time for the Next Step

Billard, Marie-Noëlle; Bont, Louis J (American Thoracic Society, 2021-03-01)
Burden of respiratory syncytial virus infection in community-dwelling older adults in Europe (RESCEU): An international prospective cohort study

RESCEU Investigators (European Respiratory Society, 2021-04)

Background: Respiratory syncytial virus (RSV) infection in older adults is recognised as an important health issue. We aimed to assess the community burden of RSV in Europe in older adults aged >60 years. Methods: This ...
Transcriptome of airway neutrophils reveals an interferon response in life-threatening respiratory syncytial virus infection

Besteman, Sjanna B.; Callaghan, Amie; Langedijk, Annefleur C.; Hennus, Marije P.; Meyaard, Linde; Mokry, Michal; Bont, Louis J.; Calis, Jorg J.A. (Academic Press Inc., 2020-11)

BACKGROUND: Neutrophils are the most abundant cell type infiltrating the airways during severe respiratory syncytial virus (RSV) infection. Their exact role in disease pathophysiology remains enigmatic. Therefore, we ...
Comparison of illumina versus nanopore 16s rRNA gene sequencing of the human nasal microbiota

Heikema, Astrid P.; Horst-Kreft, Deborah; Boers, Stefan A.; Jansen, Rick; Hiltemann, Saskia D.; de Koning, Willem; Kraaij, Robert; de Ridder, Maria A.J.; van Houten, Chantal B.; Bont, Louis J.; Stubbs, Andrew P.; Hays, John P. (Multidisciplinary Digital Publishing Institute (MDPI), 2020-09-21)

Illumina and nanopore sequencing technologies are powerful tools that can be used to determine the bacterial composition of complex microbial communities. In this study, we compared nasal microbiota results at genus level ...
Thrombocytopenia and the effect of platelet transfusions on the occurrence of intracranial hemorrhage in patients with acute leukemia - a nested case-control study

Cornelissen, Loes L.; Kreuger, Aukje L.; Caram-Deelder, Camila; Middelburg, Rutger A.; Kerkhoffs, Jean Louis H.; von dem Borne, Peter A.; Beckers, Erik A.M.; de Vooght, Karen M.K.; Kuball, Jürgen; Zwaginga, J. J.; van der Bom, Johanna G. (Springer-Verlag, 2021-01)

We designed a study to describe the incidence of intracranial hemorrhage according to severity and duration of thrombocytopenia and to quantify the associations of platelet transfusions with intracranial hemorrhage in ...

Now showing items 18241-18260 of 40729