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Now showing items 16781-16800 of 40729

Precision psychiatry: promise for the future or rehash of a fossilised foundation?

Köhne, Annemarie C J; van Os, Jim (Cambridge University Press, 2021-07)

Precision psychiatry is currently described as an approach that would bring significant advance to psychiatric clinical practice. Theaim of this article is to investigate Precision Psychiatry's promise for the future; ...
Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective

EU-GEI High Risk Study (Oxford University Press, 2021-07)

BACKGROUND: The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms ...
Association of the kynurenine pathway metabolites with clinical, cognitive features and IL-1β levels in patients with schizophrenia spectrum disorder and their siblings

Noyan, Handan; Erdağ, Ece; Tüzün, Erdem; Yaylım, İlhan; Küçükhüseyin, Özlem; Hakan, Mehmet Tolgahan; Gülöksüz, Sinan; Rutten, Bart P.F.; Saka, Meram Can; Atbaşoğlu, Cem; Alptekin, Köksal; van Os, Jim; Üçok, Alp (Elsevier, 2021-03)

Objective: There is evidence suggesting that tryptophan (TRP)-kynurenine (KYN) pathway dysregulation is involved in the pathophysiology of schizophrenia and is regulated by inflammatory cytokines. The study investigate for ...
Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years

Karolinska Schizophrenia Project (KaSP) (Wiley-Liss Inc., 2022-01)

Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the ...
Simvastatin Augmentation for Patients With Early-Phase Schizophrenia-Spectrum Disorders: A Double-Blind, Randomized Placebo-Controlled Trial

Sommer, Iris E; Gangadin, Shiral S; de Witte, Lot D; Koops, Sanne; van Baal, C; Bahn, Sabine; Drexhage, Hemmo; van Haren, N E M; Veling, Wim; Bruggeman, R; Martens, Peter; Wiersma, Sybren; Veerman, Selene R T; Grootens, Koen P; van Beveren, Nico; Kahn, Rene S; Begemann, Marieke J H (Oxford University Press, 2021-07)

Schizophrenia-spectrum disorders (SSD) are associated with increased inflammatory markers, both in brain and periphery. Augmentation with drugs that lower this pro-inflammatory status may improve clinical presentation. ...
The probability of receiving a kidney transplantation in end-stage kidney disease patients who are treated with haemodiafiltration or haemodialysis: a pooled individual participant data from four randomised controlled trials

HDF Pooling Project Investigators (BioMed Central, 2021-02-25)

BACKGROUND: Due to a critical shortage of available kidney grafts, most patients with Stage 5 Chronic Kidney Disease (CKD5) require bridging dialysis support. It remains unclear whether treatment by different dialysis ...
Right-Left Ventricular Interaction in Left-Sided Heart Failure With and Without Venoarterial Extracorporeal Membrane Oxygenation Support-A Simulation Study

Donker, Dirk W; Sallisalmi, Marko; Broomé, Michael (Lippincott Williams & Wilkins, 2021-03-01)

Left ventricular (LV) dilatation is commonly seen with LV failure and is often aggravated during venoarterial extracorporeal membrane oxygenation (VA ECMO). In this context, the intricate interaction between left and right ...
Low plasma magnesium concentration and future abdominal aortic calcifications in moderate chronic kidney disease

Ter Braake, Anique D; Govers, Larissa P; Peeters, Mieke J; van Zuilen, Arjan D; Wetzels, Jack F M; Blankestijn, Peter J; Hoenderop, Joost G J; de Baaij, Jeroen H F; van den Brand, Jan A J G; MASTERPLAN Study Group (BioMed Central, 2021-02-25)

BACKGROUND: Higher plasma magnesium concentrations are associated with reduced cardiovascular disease risk in chronic kidney disease (CKD) patients. The importance of plasma magnesium concentration for vascular calcification ...
Gamma camera characterization at high holmium-166 activity in liver radioembolization

Stella, M; Braat, Arthur; Lam, Marnix; de Jong, Hugo; van Rooij, Rob (Springer International Publishing AG, 2021-03-02)

Background High activities of holmium-166 (166Ho)–labeled microspheres are used for therapeutic radioembolization, ideally directly followed by SPECT imaging for dosimetry purposes. The resulting high-count rate potentially ...
Nodular Fasciitis With Malignant Morphology and a COL6A2-USP6 Fusion: A Case Report (of a 10-Year-old Boy)

Tomassen, Tess; van de Ven, Cees; Anninga, Jakob; Koelsche, Christian; Hiemcke-Jiwa, Laura S; Ter Horst, Simone; de Leng, Wendy W; Tirode, Franck; Karanian, Marie; Flucke, Uta (SAGE Publications Inc., 2021-09)

Nodular fasciitis is usually a benign lesion genetically characterized by ubiquitin-specific protease 6 (USP6) rearrangements. We present a case of a 10-year-old boy with a 1.5-week history of a painless mass on the right ...
P62-positive aggregates are homogenously distributed in the myocardium and associated with the type of mutation in genetic cardiomyopathy

van der Klooster, Zoë Joy; Sepehrkhouy, Shahrzad; Dooijes, Dennis; Te Rijdt, Wouter P; Schuiringa, Frederique S A M; Lingeman, Jolanthe; van Tintelen, Johannes Peter; Harakalova, Magdalena; Goldschmeding, Roel; Suurmeijer, Albert J H; Asselbergs, Folkert W; Vink, Aryan (Wiley-Blackwell, 2021-03)

Genetic cardiomyopathy is caused by mutations in various genes. The accumulation of potentially proteotoxic mutant protein aggregates due to insufficient autophagy is a possible mechanism of disease development. The objective ...
The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care

PLCRC Study Group (Nature Publishing Group, 2021-12)

Real-world data (RWD) sources are important to advance clinical oncology research and evaluate treatments in daily practice. Since 2013, the Prospective Dutch Colorectal Cancer (PLCRC) cohort, linked to the Netherlands ...
Re-evaluating inclusion criteria for autologous hematopoietic stem cell transplantation in advanced systemic sclerosis: Three successful cases and review of the literature

Shah, Ankoor; Spierings, Julia; van Laar, Jaap; Sullivan, Keith M (SAGE Publications Ltd, 2021-06)

Systemic sclerosis is a chronic autoimmune disease with a poor prognosis, particularly when a patient has rapidly progressive skin or pulmonary involvement. Autologous hematopoietic stem cell transplant is an emerging ...
The combined use of steroids and immune checkpoint inhibitors in brain metastasis patients: a systematic review and meta-analysis

Jessurun, Charissa A C; Hulsbergen, Alexander F C; de Wit, Anouk E; Tewarie, Ishaan A; Snijders, Tom J; Verhoeff, Joost J C; Phillips, John; Reardon, David A; Mekary, Rania A; Broekman, Marike L D (Oxford University Press, 2021-08-01)

BACKGROUND: Immune checkpoint inhibitors (ICI) have been a breakthrough for selected cancer patients, including those with brain metastases (BMs). Likewise, steroids have been an integral component of symptomatic management ...
Impact of the COVID-19 pandemic on quality of life and emotional wellbeing in patients with bone metastases treated with radiotherapy: a prospective cohort study

Bartels, M M T J; Gal, R; van der Velden, J M; Verhoeff, J J C; Verlaan, J J; Verkooijen, H M (Springer Netherlands, 2021-04)

Implementation of COVID-19 measures may have induced concerns about access and quality of health care for cancer patients with bone metastases, and it may have affected their quality of life. In this study, we evaluated ...
Acardiac twin pregnancies part V: Why does an acardiac twin with renal tissue produce polyhydramnios?

van Gemert, Martin J.C.; Nikkels, Peter G.J.; Ross, Michael G.; van den Wijngaard, Jeroen P.H.M. (John Wiley & Sons Inc., 2021-04-01)

Background: Acardiac twinning is a complication of monochorionic twin pregnancies. From literature reports, 30 of 41 relatively large acardiac twins with renal tissue produced polyhydramnios within their amniotic compartment. ...
Interleukin-6 receptor antagonists in critically ill patients with covid-19

REMAP-CAP Investigators (Massachussetts Medical Society, 2021-04-22)

BACKGROUND: The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. METHODS We evaluated tocilizumab and sarilumab in an ongoing international, ...
Parents' perspectives on nusinersen treatment for children with spinal muscular atrophy

van Kruijsbergen, Mette; Schröder, Carin D; Ketelaar, Marjolijn; van der Pol, W Ludo; Cuppen, Inge; van der Geest, Annette; Asselman, Fay-Lynn; Fischer, Maarten J; Visser-Meily, Johanna M A; Kars, Marijke C (Wiley-Blackwell, 2021-07)

Aim: To gain insight into parents’ perspectives about their decision-making process concerning nusinersen treatment for their child, including perceived needs and concerns, and to explore factors that influence this process. ...
Anxiety in Hospice Inpatients With Advanced Cancer, From the Perspective of Their Informal Caregivers: A Qualitative Study

Duijn, Jette M.; Zweers, Danielle; Kars, Marijke C.; de Graeff, Alexander; Teunissen, Saskia C.C.M. (Lippincott Williams and Wilkins Ltd., 2021-04-01)

Anxiety is a common symptom in patients with advanced cancer. Early recognition of anxiety is difficult, especially when the physical condition of patients declines and patients are not able to verbally express about their ...
Effect of therapeutic hypothermia on renal and myocardial function in asphyxiated (near) term neonates: A systematic review and meta-analysis

van Wincoop, Maureen; de Bijl-Marcus, Karen; Lilien, Marc; van den Hoogen, Agnes; Groenendaal, Floris (Public Library of Science, 2021-02-25)

BACKGROUND: Therapeutic hypothermia (TH) is a well-established neuroprotective therapy applied in (near) term asphyxiated infants. However, little is known regarding the effects of TH on renal and/or myocardial function. ...

Now showing items 16781-16800 of 40729