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Meat Intake Is Associated with a Higher Risk of Ulcerative Colitis in a Large European Prospective Cohort Studyø

Dong, Catherine; Chan, Simon S M; Jantchou, Prevost; Racine, Antoine; Oldenburg, Bas; Weiderpass, Elisabete; Heath, Alicia K; Tong, Tammy Y N; Tjønneland, Anne; Kyrø, Cecilie; de Mesquita, Bas Bueno; Kaaks, Rudolf; Katzke, Verena A; Bergman, Manuela M; Boeing, Heiner; Palli, Domenico; Masala, Giovanna; Tumino, Rosario; Sacerdote, Carlotta; Colorado-Yohar, Sandra M; Sánchez, Maria-Jose; Grip, Olof; Lindgren, Stefan; Luben, Robert; Huybrechts, Inge; Gunter, Marc J; Mahamat-Saleh, Yahya; Boutron-Ruault, Marie-Christine; Carbonnel, Franck (Elsevier, 2022-08-30)

BACKGROUND AND AIMS: We aimed to investigate the association between protein intake and risk of inflammatory bowel disease [IBD] in the European Prospective Investigation into Cancer and Nutrition. METHODS: A total of 413 ...
Cerebrospinal fluid volume improves prediction of malignant edema after endovascular treatment of stroke

Kauw, Frans; Bernsen, Marie Louise; Dankbaar, Jan Willem; de Jong, Hugo; Kappelle, Jaap; Velthuis, Birgitta K; Van der Worp, H B; van der Lugt, Aad; Roos, Y B; Yo, Lonneke; van Walderveen, Marianne Aa; Hofmeijer, Jeannette; Bennink, Edwin (SAGE Publications Ltd, 2023-02)

Background: The ratio of intracranial cerebrospinal fluid (CSF) volume to intracranial volume (ICV) has been identified as a potential predictor of malignant edema formation in patients with acute ischemic stroke. Aims: ...
Clustering of lung diseases in the family of interstitial lung disease patients

Terwiel, Michelle; Grutters, Jan C; van Moorsel, Coline H M (BioMed Central, 2022-04-07)

Background: The presence of familial interstitial lung disease (ILD) has been found to predict development of progressive pulmonary fibrosis. However, the role of non-ILD lung diseases in ILD patients’ families has not yet ...
A new hemophilia carrier nomenclature to define hemophilia in women and girls: Communication from the SSC of the ISTH

van Galen, Karin P.M.; d’Oiron, Roseline; James, Paula; Abdul-Kadir, Rezan; Kouides, Peter A.; Kulkarni, Roshni; Mahlangu, Johnny N.; Othman, Maha; Peyvandi, Flora; Rotellini, Dawn; Winikoff, Rochelle; Sidonio, Robert F. (Wiley-Blackwell, 2021-08)

Hemophilia A and B predominantly attracts clinical attention in males due to X-linked inheritance, introducing a bias toward female carriers to be asymptomatic. This common misconception is contradicted by an increasing ...
Genome-wide analysis of somatic noncoding mutation patterns in cancer

Dietlein, Felix; Wang, Alex B; Fagre, Christian; Tang, Anran; Besselink, Nicolle J M; Cuppen, Edwin; Li, Chunliang; Sunyaev, Shamil R; Neal, James T; Van Allen, Eliezer M (American Association for the Advancement of Science, 2022-04-08)

We established a genome-wide compendium of somatic mutation events in 3949 whole cancer genomes representing 19 tumor types. Protein-coding events captured well-established drivers. Noncoding events near tissue-specific ...
Social participation is reduced in type 3 Von Willebrand disease patients and in patients with a severe bleeding phenotype

WiN Study Group (Wiley-Blackwell, 2022-03)

Introduction: The negative impact of haemophilia on social participation is well established in previous studies, however, the impact of Von Willebrand disease (VWD) on social participation has not been studied. Aim: To ...
Efficient cascaded V-net optimization for lower extremity CT segmentation validated using bone morphology assessment

Kuiper, Ruurd J.A.; Sakkers, Ralph J.B.; van Stralen, Marijn; Arbabi, Vahid; Viergever, Max A.; Weinans, Harrie; Seevinck, Peter R. (John Wiley & Sons Inc., 2022-12)

Semantic segmentation of bone from lower extremity computerized tomography (CT) scans can improve and accelerate the visualization, diagnosis, and surgical planning in orthopaedics. However, the large field of view of these ...
Synthetic CT for the planning of MR-HIFU treatment of bone metastases in pelvic and femoral bones: a feasibility study

Lena, Beatrice; Florkow, Mateusz C.; Ferrer, Cyril J.; van Stralen, Marijn; Seevinck, Peter R.; Vonken, Evert Jan P.A.; Boomsma, Martijn F.; Slotman, Derk J.; Viergever, Max A.; Moonen, Chrit T.W.; Bos, Clemens; Bartels, Lambertus W. (Springer-Verlag, 2022-07)

Objectives: Visualization of the bone distribution is an important prerequisite for MRI-guided high-intensity focused ultrasound (MRI-HIFU) treatment planning of bone metastases. In this context, we evaluated MRI-based ...
Metastasectomy or Stereotactic Body Radiation Therapy With or Without Systemic Therapy for Oligometastatic Esophagogastric Cancer

Kroese, Tiuri E; Buijs, George S; Burger, Matthijs D L; Ruurda, Jelle P; Mook, Stella; Brosens, Lodewijk A A; van Rossum, Peter S N; van Hillegersberg, Richard (Springer New York, 2022-08)

BACKGROUND: The primary goal of this study was to determine overall survival (OS) in patients who underwent local treatment (metastasectomy or stereotactic body radiotherapy [SBRT]) or systemic therapy (chemotherapy or ...
Detecting Interval Distant Metastases With 18F-FDG PET/CT After Neoadjuvant Chemoradiotherapy for Locally Advanced Esophageal Cancer

Kroese, Tiuri E; Ruurda, Jelle P; Bakker, Anne S; Jairam, Jasvir; Mook, Stella; van der Horst, Sylvia; Meijer, Gert J; Haj Mohammad, Nadia; van Rossum, Peter S N; van Hillegersberg, Richard (Lippincott Williams & Wilkins, 2022-06-01)

PURPOSE: Patients with esophageal cancer can develop distant metastases between the start of neoadjuvant chemoradiotherapy (nCRT) and planned surgery (ie, interval distant metastases). 18F-FDG PET/CT restaging after nCRT ...
Clinical implementation and feasibility of long-course fractionated MR-guided chemoradiotherapy for patients with esophageal cancer: An R-IDEAL stage 1b/2a evaluation of technical innovation

Boekhoff, M. R.; Bouwmans, R.; Doornaert, P. A.H.; Intven, M. P.W.; Lagendijk, J. J.W.; van Lier, A. L.H.M.W.; Rasing, M. J.A.; van de Ven, S.; Meijer, G. J.; Mook, S. (Elsevier Ireland Ltd, 2022-05)

Purpose: This R-Ideal stage 1b/2a study describes the workflow and feasibility of long-course fractionated online adaptive MR-guided chemoradiotherapy with reduced CTV-to-PTV margins on the 1.5T MR-Linac for patients with ...
A 6-year follow-up study in a community-based population: Is neighbourhood-level social capital associated with the risk of emergence and persistence of psychotic experiences and transition to psychotic disorder?

Ergül, Ceylan; Drukker, Marjan; Binbay, Tolga; Kirli, Umut; Elbi, Hayriye; Alptekin, Köksal; Van Os, Jim (Cambridge University Press, 2023-07)

Background Social capital is thought to represent an environmental factor associated with the risk of psychotic disorder (PD). This study aims to investigate the association between neighbourhood-level social capital and ...
Genetic variants associated with longitudinal changes in brain structure across the lifespan

IMAGEN Consortium (Nature Research, 2022-04)

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified ...
Rare coding variants in ten genes confer substantial risk for schizophrenia

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER) (Nature Research, 2022-04)

Rare coding variation has historically provided the most direct connections between gene function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 schizophrenia cases and 97,322 controls, we implicate ...
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Indonesia Schizophrenia Consortium (Nature Research, 2022-04)

Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control ...
Cognitive dysfunction in schizophrenia: An expert group paper on the current state of the art

Harvey, Philip D.; Bosia, Marta; Cavallaro, Roberto; Howes, Oliver D.; Kahn, René S.; Leucht, Stefan; Müller, Daniel R.; Penadés, Rafael; Vita, Antonio (Elsevier, 2022-09)

Cognitive impairment in schizophrenia represents one of the main obstacles to clinical and functional recovery. This expert group paper brings together experts in schizophrenia treatment to discuss scientific progress in ...
Response to immune checkpoint inhibitors in acral melanoma: A nationwide cohort study

van Not, Olivier J; de Meza, Melissa M; van den Eertwegh, Alfons J M; Haanen, John B; Blank, Christian U; Aarts, Maureen J B; van den Berkmortel, Franchette W P J; van Breeschoten, Jesper; de Groot, Jan-Willem B; Hospers, Geke A P; Ismail, Rawa K; Kapiteijn, Ellen; Piersma, Djura; van Rijn, Roos S; Stevense-den Boer, Marion A M; van der Veldt, Astrid A M; Vreugdenhil, Gerard; Bonenkamp, Han J; Boers-Sonderen, Marye J; Blokx, Willeke A M; Wouters, Michel W J M; Suijkerbuijk, Karijn P M (Elsevier Limited, 2022-05)

Background: Recent reports suggest the limited efficacy of immune checkpoints inhibitors in advanced acral melanoma (AM). This study aims to investigate the clinical outcomes of immune checkpoint inhibitors in patients ...
Prevalence of non-alcoholic fatty liver disease (NAFLD) and its association with surrogate markers of insulin resistance in patients with type 1 diabetes

de Vries, Marieke; Westerink, Jan; El-Morabit, Fatima; Kaasjager, H. A.H.(Karin); de Valk, Harold W. (Elsevier Ireland Ltd, 2022-04)

Aims: Assess prevalence of hepatic steatosis (HS) and of fibrosis in an unselected population of patients with type 1 diabetes. Describe their clinical profile and explore the association between insulin resistance and ...
Case Report: Lessons Learned From Subsequent Autologous and Allogeneic Hematopoietic Stem Cell Transplantations in a Pediatric Patient With Relapsing Polychondritis

Veldkamp, Saskia R.; Jansen, Marc H.A.; Swart, Joost F.; Lindemans, Caroline A. (Frontiers Media S. A., 2022-03-10)

Background: Autologous hematopoietic stem cell transplantation (autoHSCT) is increasingly being recognized as a treatment option for severe refractory autoimmune diseases (AD). However, efficacy is hampered by high relapse ...
Early Surgery Prolongs Professional Activity in IDH Mutant Low-Grade Glioma Patients: A Policy Change Analysis

Robe, Pierre A.; Rados, Matea; Spliet, Wim G.; Hoff, Reinier G.; Gosselaar, Peter; Broekman, Marike L.D.; van Zandvoort, Martine J.; Seute, Tatjana; Snijders, Tom J. (Frontiers Media S. A., 2022-03-09)

Background: Until 2015, Dutch guidelines recommended follow-up and biopsy rather than surgery as initial care for suspected low-grade gliomas (LGG). Given evidence that surgery could extend patient survival, our center ...

Now showing items 13001-13020 of 40729