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UMC Repository: Recent submissions

  • Circulating levels of testosterone, sex hormone binding globulin and colorectal cancer risk: Observational and mendelian randomization analyses 
    Dimou, Niki; Mori, Nagisa; Harlid, Sophia; Harbs, Justin; Martin, Richard M.; Smith-Byrne, Karl; Papadimitriou, Nikos; Timothy Bishop, D.; Casey, Graham; Colorado-Yohar, Sandra M.; Cotterchio, Michelle; Cross, Amanda J.; Le Marchand, Loic; Lin, Yi; Offit, Kenneth; Charlotte Onland-Moret, N.; Peters, Ulrike; Potter, John D.; Rohan, Thomas E.; Weiderpass, Elisabete; Gunter, Marc J.; Murphy, Neil (2021-07)
    Background: Epidemiologic studies evaluating associations between sex steroid hormones and colorectal cancer risk have yielded inconsistent results. To elucidate the role of circulating levels of testosterone, and sex ...
  • Development of a Pipeline for Adverse Drug Reaction Identification in Clinical Notes: Word Embedding Models and String Matching 
    Siegersma, Klaske R.; Evers, Maxime; Bots, Sophie H.; Groepenhoff, Floor; Appelman, Yolande; Hofstra, Leonard; Tulevski, Igor I.; Somsen, G. Aernout; den Ruijter, Hester M.; Spruit, Marco; Onland-Moret, N. Charlotte (JMIR Publications Inc., 2022-01)
    Background: Knowledge about adverse drug reactions (ADRs) in the population is limited because of underreporting, which hampers surveillance and assessment of drug safety. Therefore, gathering accurate information that can ...
  • Statins are associated with a large reduction in all-cause mortality in women from a cardiac outpatient population 
    Bots, Sophie H.; Onland-Moret, N. Charlotte; Jancev, Milena; Hollander, Monika; Tulevski, Igor I.; Hofstra, Leonard; Somsen, G. Aernoud; Den Ruijter, Hester M. (BMJ Publishing Group, 2022-04-20)
    Objectives Uncertainty about the benefit of (high-intensity) statins for women remains due to under-representation of women in primary prevention trials and scarcity of sex-stratified data. This study evaluates the ...
  • State of the art of CT myocardial perfusion 
    Muscogiuri, Giuseppe; Palumbo, Pierpaolo; Kitagawa, Kakuya; Nakamura, Satoshi; Senatieri, Alberto; De Cecco, Carlo Nicola; Gershon, Gabrielle; Chierchia, Gregorio; Usai, Jessica; Sferratore, Daniele; D’Angelo, Tommaso; Guglielmo, Marco; Dell’Aversana, Serena; Jankovic, Sonja; Salgado, Rodrigo; Saba, Luca; Cau, Riccardo; Marra, Paolo; Di Cesare, Ernesto; Sironi, Sandro (Springer Verlag Italia, 2025-03)
    Coronary computed tomography angiography (CCTA) is a powerful tool to rule out coronary artery disease (CAD). In the last decade, myocardial perfusion CT (CTP) technique has been developed for the evaluation of myocardial ...
  • Sex Differences in the Relationship between New York Heart Association Functional Classification and Survival in Cardiovascular Disease Patients: A Mediation Analysis of Exercise Capacity with Regular Care Data 
    Siegersma, Klaske R.; Stens, Niels A.; Groepenhoff, Floor; Appelman, Yolande; Tulevski, Igor I.; Hofstra, Leonard; den Ruijter, Hester M.; Somsen, G. Aernout; Onland-Moret, N. Charlotte (IMR Press Limited, 2022-08)
    Background: The New York Heart Association (NYHA) functional class has extensively been used for risk stratification in patients suspected of heart failure, although its prognostic value differs between sexes and disease ...
  • Sex Differences in Reported Adverse Drug Reactions to Angiotensin-Converting Enzyme Inhibitors 
    Bots, Sophie H.; Schreuder, Michelle M.; Roeters Van Lennep, Jeanine E.; Watson, Sarah; Van Puijenbroek, Eugène; Onland-Moret, N. Charlotte; Den Ruijter, Hester M. (American Medical Association, 2022-04-20)
  • The APOE locus is linked to decline in general cognitive function: 20-years follow-up in the Doetinchem Cohort Study 
    Rietman, M. Liset; Onland-Moret, N. Charlotte; Nooyens, Astrid C.J.; Ibi, Dorina; van Dijk, Ko Willems; Samson, Leonard Daniël; Pennings, Jeroen L.A.; Schipper, Maarten; Wong, Albert; Spijkerman, Annemieke M.W.; Dollé, Martijn E.T.; Verschuren, W. M.Monique (Nature Publishing Group, 2022-12)
    Cognitive decline is part of the normal aging process. However, some people experience a more rapid decline than others due to environmental and genetic factors. Numerous single nucleotide polymorphisms (SNPs) have been ...
  • Diaphragm Pacing in Early Critical Illness?: A Plea for a Super-relaxed Approach 
    Heunks, Leo; Donker, Dirk W; Oppersma, Eline; Ottenheijm, Coen A C; Doorduin, Jonne (American Thoracic Society, 2025-03)
  • Results at 1 Year from SATURN, A European, Prospective, Multicenter Registry for Male Stress Urinary Incontinence Surgery 
    Heesakkers, John; Martens, Frank; Thiruchelvam, N.; Witjes, Wim; Caris, Christien; Kats, Joni; Hamid, R.; Van der Aa, F.; the EAU Research Foundation SATURN Study Group (Elsevier, 2024-09)
    Background and objective: The European, prospective, multicenter SATURN registry was developed to analyze surgical devices for male stress urinary incontinence. The primary objective is the cure rate during follow-up. ...
  • The 'Brussels 4': essential requirements for implantable brain-computer interface user autonomy 
    Oxley, Tom; Deo, Darrel Rohit; Cernera, Stephanie; Sawyer, Abbey; Putrino, David; Ramsey, Nick F; Fry, Adam (IOP Publishing Ltd., 2025-02-06)
    Objective. Implantable brain-computer interfaces (iBCIs) hold great promise for individuals with severe paralysis and are advancing toward commercialization. The features required for successful clinical translation and ...
  • Development of a Caco-2-based intestinal mucosal model to study intestinal barrier properties and bacteria-mucus interactions 
    Floor, Evelien; Su, Jinyi; Chatterjee, Maitrayee; Kuipers, Elise S; IJssennagger, Noortje; Heidari, Faranak; Giordano, Laura; Wubbolts, Richard W; Mihăilă, Silvia M; Stapels, Daphne A C; Vercoulen, Yvonne; Strijbis, Karin (Landes Bioscience, 2025)
    The intestinal mucosal barrier is a dynamic system that allows nutrient uptake, stimulates healthy microbe-host interactions, and prevents invasion by pathogens. The mucosa consists of epithelial cells connected by cellular ...
  • Timing of Complete Multivessel Revascularization in Acute Coronary Syndrome: 2-Year Results of the BIOVASC Study 
    den Dekker, Wijnand K.; Elscot, Jacob J.; Bennett, Johan; Schotborgh, Carl E.; van der Schaaf, Rene; Sabaté, Manel; Moreno, Raúl; Ameloot, Koen; van Bommel, Rutger J.; Forlani, Daniele; van Reet, Bert; Esposito, Giovanni; Dirksen, Maurits T.; Ruifrok, Willem P.T.; Everaert, Bert R.C.; Van Mieghem, Carlos; Cummins, Paul; Lenzen, Mattie; Brugaletta, Salvatore; Boersma, Eric; Van Mieghem, Nicolas M.; Diletti, Roberto; den Dekker, Wijnand K.; Van Mieghem, Nicolas M.; Schotborgh, Carl E.; van der Schaaf, René J.; van Bommel, Rutger J.; Dirksen, Maurits T.; Ruifrok, Willem T.; Jessurun, Gillian A.J.; Magro, Michael; Voskuil, Michiel; Vlachojannis, George J.; Beijk, Marcel A.M.; Barzouhi, Abdelilah el; van der Heijden, Dirk J.; Bennett, Johan; Ameloot, Koen; Vrolix, Mathias; Van Reet, Bert; Everaert, Bert R.; Vandeloo, Bert; Van Mieghem, Carlos; Stammen, Francis; Verheye, Stefan; Forlani, Daniele; Di Marco, Massimo; Paloscia, Leonardo; Esposito, Giovanni; Franzone, Anna; Berti, Sergio; De Caterina, Alberto R.; Ciardetti, Marco; Secco, Gioel G.; Sabaté, Manel; Brugaletta, Salvatore; Moreno, Raúl; Pinar, Eduardo; Alfonso, Fernando; Amat, Ignacio J.; Moris, Cesar; Sabaté, Manel; Daemen, Joost; Garcia-Garcia, Hector M.; McFadden, Eugène; Andersen, Grethe; Tijssen, Jan G.P.; ten Berg, Jurriën M.; Verheugt, Freek W.A. (Elsevier, 2024-12-23)
    Background: In patients with acute coronary syndromes (ACS) and multivessel coronary disease, immediate complete revascularization was noninferior to staged complete revascularization for the primary composite outcome at ...
  • Missing values and inconclusive results in diagnostic studies – A scoping review of methods 
    Stahlmann, Katharina; Reitsma, Johannes B.; Zapf, Antonia (SAGE Publications Ltd, 2023-09)
    Most diagnostic studies exclude missing values and inconclusive results from the analysis or apply simple methods resulting in biased accuracy estimates. This may be due to the lack of availability or awareness of appropriate ...
  • Ancestral SARS-CoV-2 and Omicron BA.5-specific neutralizing antibody and T-cell responses after Omicron bivalent booster vaccination in previously infected and infection-naive individuals 
    Mak, Willem A.; Visser, Wendy; van der Vliet, Marijke; Markus, Hilde Y.; Koeleman, Johannes G.M.; Ong, David S.Y. (John Wiley & Sons Inc., 2023-08)
    Coronavirus disease-2019 (COVID-19) bivalent ancestral/Omicron messenger RNA (mRNA) booster vaccinations became available to boost and expand the immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ...
  • Impact of recurrent ischaemic and bleeding events on quality of life in patients with acute coronary syndrome: Insights from the FORCE-ACS registry 
    Van Der Sangen, Niels M.R.; Azzahhafi, Jaouad; Chan Pin Yin, Dean R.P.P.; Rayhi, Senna; Van Weede, Victoria M.; Walhout, Ronald J.; Tjon Joe Gin, Melvyn; Pisters, Ron; Nicastia, Deborah M.; Langerveld, Jorina; Vlachojannis, Georgios J.; Van Bommel, Rutger J.; Appelman, Yolande; Henriques, José P.S.; Ten Berg, Jurriën; Kikkert, Wouter (BMJ Publishing Group, 2023-08-01)
    Objective Patients with acute coronary syndrome (ACS) remain at high risk for recurrent ischaemic and bleeding events during follow-up. Our study aimed to quantify and compare the impact of these adverse events on quality ...
  • Understanding the impact of tuberous sclerosis complex: development and validation of the TSC-PROM 
    Müller, Annelieke R.; Luijten, Michiel A.J.; Haverman, Lotte; de Ranitz-Greven, Wendela L.; Janssens, Peter; Rietman, André B.; ten Hoopen, Leontine W.; de Graaff, Laura C.G.; de Wit, Marie Claire; Jansen, Anna C.; Gipson, Tanjala; Capal, Jamie K.; de Vries, Petrus J.; van Eeghen, Agnies M. (BioMed Central Ltd., 2023-12)
    Background: Tuberous sclerosis complex (TSC) is a rare and complex genetic disorder, associated with tumor growth in various organ systems, epilepsy, and a range of neuropsychiatric manifestations including intellectual ...
  • Vaccination practices in pediatric transplantation: A survey among member centers of the European reference network TransplantChild 
    Donà, Daniele; Bravo-Gallego, Luz Yadira; Remacha, Esteban Frauca; Cananzi, Mara; Gastaldi, Andrea; Canizalez, Juan Torres; Stephenne, Xavier; Lacaille, Florence; Lindemans, Caroline; Calore, Elisabetta; Galea, Nathalie; Benetti, Elisa; Nachbaur, Edith; Sandes, Ana Rita; Teixeira, Ana; Ferreira, Sandra; Klaudel-Dreszler, Maja; Ackermann, Oanez; Boyer, Olivia; Espinosa, Laura; Guereta, Luis García; Sciveres, Marco; Fischler, Björn; Schwerk, Nicolaus; Neland, Mette; Nicastro, Emanuele; Dello Strologo, Luca; Toporski, Jacek; Vainumae, Inga; Rascon, Jelena; Urbonas, Vaidotas; del Rosal, Teresa; López-Granados, Eduardo; Perilongo, Giorgio; Baker, Alastair; Vega, Paloma Jara (Wiley-Blackwell, 2023-11)
    Background: There is considerable variation in vaccination practices between pediatric transplant centers. This study aims to evaluate active immunization attitudes and practices among ERN-TransplantChild centers and ...
  • Trauma registries: towards global standardisation and outcome evaluation 
    Houwert, Roderick Marijn; Balogh, Zsolt Janos; Lefering, Rolf (Springer International Publishing AG, 2023-08)
  • Visualization of contractions: Evaluation of a new experience design concept to enhance the childbirth experience 
    Thijssen, Kirsten M.J.; Kierkels, Jeanine J.M.; van Meurs, Andrea; Verhoeven, Corine J.; van der Hout-van der Jagt, M. Beatrijs; Oei, S. Guid (Wiley-Blackwell, 2023-12)
    Background: The purpose of this study was to develop and evaluate an innovative design proposition intended to help enhance the childbirth experience. The innovation consists of a smartphone application for birth preparation ...
  • A novel germline PAX5 single exon deletion in a pediatric patient with precursor B-cell leukemia 
    van Engelen, N.; Roest, M.; van Dijk, F.; Sonneveld, E.; Bladergroen, R.; van Reijmersdal, S. V.; van der Velden, V. H.J.; Hoogeveen, P. G.; Kors, W. A.; Waanders, E.; Jongmans, M. C.J.; Kuiper, R. P. (Springer Nature, 2023-09)