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UMC Repository: Recent submissions

  • Stroke Complications in Patients Requiring Durable Mechanical Circulatory Support Systems After Extracorporeal Life Support 
    Durable MCS after ECLS Study Group (Lippincott Williams & Wilkins, 2023-02-01)
    Stroke is one of the leading complications following durable mechanical circulatory support (MCS) implantation. The aim of this multicenter study was to investigate stroke complications in patients requiring durable MCS ...
  • A diagnostic prediction model for separating juvenile idiopathic arthritis and chronic musculoskeletal pain syndrome 
    van Straalen, Joeri W; van Stigt Thans, Martine; Wulffraat, Nico M; de Roock, Sytze; Swart, Joost F (Mosby Inc., 2022-12)
    Objective: To develop and validate a diagnostic prediction model that can distinguish between juvenile idiopathic arthritis (JIA) and chronic musculoskeletal pain syndrome (CMPS) based on patient-reported outcomes. Study ...
  • The journey of neutropoiesis: how complex landscapes in bone marrow guide continuous neutrophil lineage determination 
    Overbeeke, Celine; Tak, Tamar; Koenderman, Leo (Elsevier, 2022-04-14)
    Neutrophils are the most abundant white blood cell, and they differentiate in homeostasis in the bone marrow from hematopoietic stem cells (HSCs) via multiple intermediate progenitor cells into mature cells that enter the ...
  • Hypothalamic syndrome 
    Müller, Hermann L.; Tauber, Maithé; Lawson, Elizabeth A.; Özyurt, Jale; Bison, Brigitte; Martinez-Barbera, Juan Pedro; Puget, Stephanie; Merchant, Thomas E.; van Santen, Hanneke M. (Nature Publishing Group, 2022-04-21)
    Hypothalamic syndrome (HS) is a rare disorder caused by disease-related and/or treatment-related injury to the hypothalamus, most commonly associated with rare, non-cancerous parasellar masses, such as craniopharyngiomas, ...
  • Whole-body insulin clearance in people with type 2 diabetes and normal kidney function: Relationship with glomerular filtration rate, renal plasma flow, and insulin sensitivity 
    van Baar, Michaël J B; van Bommel, Erik J M; Smits, Mark M; Touw, Daan J; Nieuwdorp, Max; Ten Kate, Reinier W; Joles, Jaap A; van Raalte, Daniël H (Elsevier, 2022-04)
    OBJECTIVE: Kidney insulin clearance, proposed to be the main route of extra-hepatic insulin clearance, occurs in tubular cells following glomerular filtration and peritubular uptake, a process that may be impaired in people ...
  • SGLT2 Inhibition and Uric Acid Excretion in Patients with Type 2 Diabetes and Normal Kidney Function 
    Suijk, Danii; van Baar, Michaël; van Bommel, Erik; Iqbal, Zainab; Krebber, Merle; Vallon, Volker; Touw, Daan; Hoorn, Ewout; Nieuwdorp, Max; Kramer, Mark; Joles, Jaap; Bjornstad, Petter; van Raalte, Daniël (Lippincott Williams & Wilkins, 2022-05)
    Background and objectives Sodium-glucose transporter 2 (SGLT2) inhibitor–induced uric acid lowering may contribute to kidney-protective effects of the drug class in people with type 2 diabetes. This study investigates ...
  • Albumin is an interface between blood plasma and cell membrane, and not just a sponge 
    van de Wouw, Jens; Joles, Jaap A (Oxford University Press, 2022-04)
    Albumin is the most abundant protein in blood plasma and acts as a carrier for many circulating molecules. Hypoalbuminaemia, mostly caused by either renal or liver disease or malnutrition, can perturb vascular homeostasis ...
  • FAIR Genomes metadata schema promoting Next Generation Sequencing data reuse in Dutch healthcare and research 
    van der Velde, K Joeri; Singh, Gurnoor; Kaliyaperumal, Rajaram; Liao, XiaoFeng; de Ridder, Sander; Rebers, Susanne; Kerstens, Hindrik H D; de Andrade, Fernanda; van Reeuwijk, Jeroen; De Gruyter, Fini E; Hiltemann, Saskia; Ligtvoet, Maarten; Weiss, Marjan M; van Deutekom, Hanneke W M; Jansen, Anne M L; Stubbs, Andrew P; Vissers, Lisenka E L M; Laros, Jeroen F J; van Enckevort, Esther; Stemkens, Daphne; 't Hoen, Peter A C; Beliën, Jeroen A M; van Gijn, Mariëlle E; Swertz, Morris A (Nature Research, 2022-04-13)
    The genomes of thousands of individuals are profiled within Dutch healthcare and research each year. However, this valuable genomic data, associated clinical data and consent are captured in different ways and stored across ...
  • Joint modeling of endpoints can be used to answer various research questions in randomized clinical trials 
    van Eijk, Ruben P A; Roes, Kit C B; van den Berg, Leonard H; Lu, Ying (Elsevier, 2022-07)
    OBJECTIVES: Correlated longitudinal and time-to-event outcomes, such as the rate of cognitive decline and the onset of Alzheimer's disease, are frequent (co-)primary and key secondary endpoints in randomized clinical trials ...
  • Sports and trauma as risk factors for Motor Neurone Disease: New Zealand case-control study 
    Chen, Grace Xia; Douwes, Jeroen; van den Berg, Leonard H; Glass, Bill; McLean, David; 't Mannetje, Andrea Martine (Wiley-Blackwell, 2022-06)
    OBJECTIVES: To assess whether sports, physical trauma and emotional trauma are associated with motor neurone disease (MND) in a New Zealand case-control study (2013-2016). METHODS: In total, 321 MND cases and 605 population ...
  • Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3'UTR protect against ALS 
    Project MinE ALS Sequencing Consortium (Nature Research, 2022-04)
    The noncoding genome is substantially larger than the protein-coding genome but has been largely unexplored by genetic association studies. Here, we performed region-based rare variant association analysis of >25,000 ...
  • Genotypic and Phenotypic Spectrum of Foveal Hypoplasia: A Multicenter Study 
    Kuht, Helen J.; Maconachie, Gail D.E.; Han, Jinu; Kessel, Line; van Genderen, Maria M.; McLean, Rebecca J.; Hisaund, Michael; Tu, Zhanhan; Hertle, Richard W.; Gronskov, Karen; Bai, Dayong; Wei, Aihua; Li, Wei; Jiao, Yonghong; Smirnov, Vasily; Choi, Jae Hwan; Tobin, Martin D.; Sheth, Viral; Purohit, Ravi; Dawar, Basu; Girach, Ayesha; Strul, Sasha; May, Laura; Chen, Fred K.; Heath Jeffery, Rachael C.; Aamir, Abdullah; Sano, Ronaldo; Jin, Jing; Brooks, Brian P.; Kohl, Susanne; Arveiler, Benoit; Montoliu, Lluis; Engle, Elizabeth C.; Proudlock, Frank A.; Nishad, Garima; Pani, Prateek; Varma, Girish; Gottlob, Irene; Thomas, Mervyn G. (Elsevier, 2022-06)
    PURPOSE: To characterize the genotypic and phenotypic spectrum of foveal hypoplasia (FH). DESIGN: Multicenter, observational study. PARTICIPANTS: A total of 907 patients with a confirmed molecular diagnosis of albinism, ...
  • Burden and benefit-A mixed methods study of informal Amyotrophic Lateral Sclerosis caregivers in Ireland and the Netherlands 
    Kennedy, Polly; Conroy, Éilís; Heverin, Mark; Leroi, Iracema; Beelen, Anita; van den Berg, Leonard; Hardiman, Orla; Galvin, Miriam (John Wiley & Sons Inc., 2022-05)
    Objectives: Amyotrophic Lateral Sclerosis (ALS) is a systemic and terminal disorder of the central nervous system which causes paralysis of limbs, respiratory and bulbar muscles, impacting on physical, communication, ...
  • The Phenotypic and Mutational Spectrum of the FHONDA Syndrome and Oculocutaneous Albinism: Similarities and Differences 
    Kruijt, Charlotte C.; Gradstein, Libe; Bergen, Arthur A.; Florijn, Ralph J.; Arveiler, Benoit; Lasseaux, Eulalie; Zanlonghi, Xavier; Bagdonaite-Bejaran, Laura; Fulton, Anne B.; Yahalom, Claudia; Blumenfeld, Anat; Perez, Yonatan; Birk, Ohad S.; De Wit, Gerard C.; Schalij-Delfos, Nicoline E.; Van Genderen, Maria M. (Association for Research in Vision and Ophthalmology Inc., 2022-01)
    PURPOSE. The purpose of this study was to further expand the mutational spectrum of the Foveal Hypoplasia, Optic Nerve Decussation defect, and Anterior segment abnormalities (FHONDA syndrome), to describe the phenotypic ...
  • Improved clinical outcomes in patients with juvenile idiopathic arthritis associated uveitis in the last decade 
    Wennink, Roos A.W.; Kalinina Ayuso, Viera; Pameijer, Els M.; Dekkers, Coco C.; Bozkir, Irem; de Boer, Joke H. (Wiley-Blackwell, 2022-11)
    Purpose: The purpose of the study was to analyse the development of ocular complications and visual prognosis in juvenile idiopathic arthritis associated uveitis (JIA-uveitis) compared to the previous decade in the light ...
  • A Blood Protein Signature Stratifies Clinical Response to csDMARD Therapy in Pediatric Uveitis 
    Wennink, Roos A.W.; Ayuso, Viera Kalinina; Tao, Weiyang; Delemarre, Eveline M.; de Boer, Joke H.; Kuiper, Jonas J.W. (Association for Research in Vision and Ophthalmology Inc., 2022-02-01)
    Purpose: To identify a serum biomarker signature that can help predict response to conventional synthetic disease-modifying antirheumatic drug (csDMARD) therapy in pediatric noninfectious uveitis. Methods: In this case-control ...
  • Impact of the COVID-19 outbreak on prostate cancer care in the Netherlands 
    Deukeren, Désirée van; Heesterman, Berdine L; Roelofs, Lianne; Kiemeney, Lambertus A; Witjes, J Alfred; Smilde, Tineke J; Leenders, Geert J L H van; Incrocci, Luca; Vanneste, Ben G L; Meijer, Richard P; Siesling, Sabine; Bezooijen, Bart P J van; Aben, Katja K H; COVID and Cancer-NL consortium (Elsevier, 2022-04-12)
    INTRODUCTION: The COVID-19 outbreak has affected care for non-COVID diseases like cancer. We evaluated the impact of the COVID-19 outbreak on prostate cancer care in the Netherlands. METHODS: Prostate cancer diagnoses per ...
  • 166Holmium–99mTechnetium dual‑isotope imaging: scatter compensation and automatic healthy‑liver segmentation for 166Holmium radioembolization dosimetry 
    Stella, M; Braat, Arthur; Lam, Marnix; de Jong, Hugo; van Rooij, Rob (Springer International Publishing AG, 2022-04-21)
    Background Partition modeling allows personalized activity calculation for holmium-166 (166Ho) radioembolization. However, it requires the definition of tumor and non-tumorous liver, by segmentation and registration of a ...
  • Conventional MRI Criteria to Differentiate Progressive Disease from Treatment-Induced Effects in High-Grade (WHO Grade 3-4) Gliomas 
    Flies, Christina M; van Leuken, Karlijn H; Voorde, Marlies Ten; Verhoeff, Joost J C; De Vos, Filip Y F; Seute, Tatjana; Robe, Pierre A; Witkamp, Theodoor D; Hendrikse, Jeroen; Dankbaar, Jan Willem; Snijders, Tom J (Lippincott Williams & Wilkins, 2022-07-05)
    BACKGROUND AND OBJECTIVES: Posttreatment radiologic deterioration of an irradiated high-grade (WHO grade 3-4) glioma (HGG) may be the result of true progressive disease or treatment-induced effects (TIE). Differentiation ...
  • Corpus callosum injury after neurosurgical intervention for posthemorrhagic ventricular dilatation and association with neurodevelopmental outcome at 2 years 
    Cizmeci, Mehmet N; Groenendaal, Floris; van der Aa, Niek E; Vandewouw, Marlee M; Young, Julia M; Han, Kuosen; Benders, Manon J N L; Taylor, Margot J; de Vries, Linda S; Woerdeman, Peter A (American Association of Neurological Surgeons, 2022-07)
    OBJECTIVE Direct injury to the corpus callosum (CC) due to neurosurgical interventions in infants with posthemorrhagic ventricular dilatation (PHVD) has not been reported in the literature. The authors observed a subset ...