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UMC Repository: Recent submissions

  • Powerful eQTL mapping through low-coverage RNA sequencing 
    Schwarz, Tommer; Boltz, Toni; Hou, Kangcheng; Bot, Merel; Duan, Chenda; Loohuis, Loes Olde; Boks, Marco P; Kahn, René S; Ophoff, Roel A; Pasaniuc, Bogdan (Elsevier, 2022-07-14)
    Mapping genetic variants that regulate gene expression (eQTL mapping) in large-scale RNA sequencing (RNA-seq) studies is often employed to understand functional consequences of regulatory variants. However, the high cost ...
  • Reappraisal of the Medical Research Council Antiepileptic Drug Withdrawal Study: contamination-adjusted and dose-response re-analysis 
    Terman, Samuel W; Wang, Chang; Wang, Lu; Braun, Kees Pj; Otte, Willem M; Slinger, Geertruida; Kerr, Wesley T; Lossius, Morten I; Bonnett, Laura; Burke, James F; Marson, Anthony (Wiley-Blackwell, 2022-07)
    Objective: The 1991 Medical Research Council (MRC) Study compared seizure relapse for seizure-free patients randomized to withdraw vs continue of antiseizure medications (ASMs). We re-analyzed this trial to account for ...
  • Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids 
    Gumbs, Stephanie B.H.; Berdenis van Berlekom, Amber; Kübler, Raphael; Schipper, Pauline J.; Gharu, Lavina; Boks, Marco P.; Ormel, Paul R.; Wensing, Annemarie M.J.; de Witte, Lot D.; Nijhuis, Monique (Multidisciplinary Digital Publishing Institute (MDPI), 2022-04-16)
    The achievement of an HIV cure is dependent on the eradication or permanent silencing of HIV-latent viral reservoirs, including the understudied central nervous system (CNS) reservoir. This requires a deep understanding ...
  • Non-alcoholic fatty liver disease: identical etiologic factors in patients with type 1 and type 2 diabetes 
    de Vries, Marieke; El-Morabit, Fatima; van Erpecum, Karel J.; Westerink, Jan; Bac, Simon T.; Kaasjager, H. A.H.(Karin); de Valk, Harold W. (Elsevier, 2022-06)
    Aims: To compare NAFLD prevalence, distribution and its etiologic determinants in patients with type 1 diabetes (T1D) and type 2 diabetes (T2D). Methods: In this cross-sectional study, NAFLD was evaluated by transient ...
  • Development of the My Positive Health dialogue tool for children: A qualitative study on children's views of health 
    De Jong-Witjes, Stacey; Kars, Marijke C.; Van Vliet, Marja; Huber, MacHteld; Van Der Laan, Sabine E.I.; Gelens, Eva N.; Van Der Sprenkel, Emma E.Berkelbach; Nijhof, Sanne L.; De Jonge, Maretha V.; Rippen, Hester; Van De Putte, Elise M. (BMJ Publishing Group, 2022-04-13)
    Background Children's views of health were explored in order to develop a health dialogue tool for children. Methods A qualitative research design was used as part of a codesign process. Based on semi-structured interviews ...
  • Short-term high-fat diet alters acetaminophen metabolism in healthy individuals 
    Achterbergh, Roos; Lammers, Laureen A; Klümpen, Heinz-Josef; Mathôt, Ron A A; Romijn, Johannes A (Lippincott Williams & Wilkins, 2022-12-01)
    BACKGROUND: Acetaminophen is metabolized through a nontoxic sulfation and glucuronidation pathway and toxic oxidation pathway (via CYP2E1 and CYP1A2). A short-term high-fat diet induces alterations in the steatotic liver ...
  • Thyroid function after diagnostic I-123-metaiodobenzylguanidine in children with neuroblastic tumors 
    Clement, Sarah C; Tytgat, Godelieve A M; van Trotsenburg, A S Paul; Kremer, Leontien C M; van Santen, Hanneke M (Springer Japan, 2022-06)
    BACKGROUND: Metaiodobenzylguanidine (MIBG) labeled with radioisotopes can be used for diagnostics 123I-) and treatment (131I-) in patients with neuroblastic tumors. Thyroid dysfunction has been reported in 52% of neuroblastoma ...
  • FDG PET/CT in differentiated thyroid cancer patients with low thyroglobulin levels 
    Lebbink, Chantal A.; de Vries, Lisa H.; Borel Rinkes, Inne H.M.; Braat, Arthur J.A.T.; van Leeuwaarde, Rachel S.; Lodewijk, Lutske; van Treijen, Mark J.C.; Vriens, Menno R.; Valk, Gerlof D.; van Santen, Hanneke M.; de Keizer, Bart (Oxford University Press, 2022-07)
    Objective: To evaluate the usefulness of [18F]fluorodeoxyglucose (FDG) positron emissive tomography (PET)/CT in patients with low detectable thyroglobulin levels suspicious for persistent or recurrent differentiated thyroid ...
  • Volumetric Bioprinting of Organoids and Optically Tuned Hydrogels to Build Liver-Like Metabolic Biofactories 
    Bernal, Paulina Nuñez; Bouwmeester, Manon; Madrid-Wolff, Jorge; Falandt, Marc; Florczak, Sammy; Rodriguez, Nuria Ginés; Li, Yang; Größbacher, Gabriel; Samsom, Roos Anne; van Wolferen, Monique; van der Laan, Luc J.W.; Delrot, Paul; Loterie, Damien; Malda, Jos; Moser, Christophe; Spee, Bart; Levato, Riccardo (Wiley-Blackwell, 2022-04)
    Organ- and tissue-level biological functions are intimately linked to microscale cell–cell interactions and to the overarching tissue architecture. Together, biofabrication and organoid technologies offer the unique potential ...
  • Viscoelastic Chondroitin Sulfate and Hyaluronic Acid Double-Network Hydrogels with Reversible Cross-Links 
    Mihajlovic, Marko; Rikkers, Margot; Mihajlovic, Milos; Viola, Martina; Schuiringa, Gerke; Ilochonwu, Blessing C.; Masereeuw, Rosalinde; Vonk, Lucienne; Malda, Jos; Ito, Keita; Vermonden, Tina (American Chemical Society, 2022-03-14)
    Viscoelastic hydrogels are gaining interest as they possess necessary requirements for bioprinting and injectability. By means of reversible, dynamic covalent bonds, it is possible to achieve features that recapitulate the ...
  • Bioink with cartilage-derived extracellular matrix microfibers enables spatial control of vascular capillary formation in bioprinted constructs 
    Terpstra, Margo L.; Li, Jinyu; Mensinga, Anneloes; de Ruijter, Mylène; van Rijen, Mattie H.P.; Androulidakis, Charalampos; Galiotis, Costas; Papantoniou, Ioannis; Matsusaki, Michiya; Malda, Jos; Levato, Riccardo (IOP Publishing Ltd., 2022-07)
    Microvasculature is essential for the exchange of gas and nutrient for most tissues in our body. Some tissue structures such as the meniscus presents spatially confined blood vessels adjacent to non-vascularized regions. ...
  • Transition From Diencephalic Syndrome to Hypothalamic Obesity in Children With Suprasellar Low Grade Glioma: A Case Series 
    van Roessel, Ichelle M.A.A.; Schouten-van Meeteren, Antoinette Y.N.; Meijer, Lisethe; Hoving, Eelco W.; Bakker, Boudewijn; van Santen, Hanneke M. (Frontiers Media S. A., 2022-04-06)
    Background: Children with suprasellar low grade glioma (LGG) frequently develop problems to maintain their body weight within the normal range, due to hypothalamic dysfunction. Hypothalamic damage may result in the ...
  • Negative life events and stress sensitivity in youth's daily life: an ecological momentary assessment study 
    Rauschenberg, Christian; Schulte-Strathaus, Julia C C; van Os, Jim; Goedhart, Matthieu; Schieveld, Jan N M; Reininghaus, Ulrich (D. Steinkopff-Verlag, 2022-08)
    PURPOSE: Negative life events (LEs) are associated with mental health problems in youth. However, little is known about underlying mechanisms. The aim of the study was to investigate whether exposure to LEs modifies stress ...
  • Percutaneous valve in all four positions 
    Aarts, H M; Kraaijeveld, A O; Stella, P R; Voskuil, M (Bohn Stafleu van Loghum, 2022-09)
  • Movement Disorders and Mortality in Severely Mentally Ill Patients: The Curacao Extrapyramidal Syndromes Study XIV 
    Willems, Anne E; Mentzel, Charlotte L; Bakker, Pieter Roberto; van Os, Jim; Tenback, Diederik E; Gelan, Petra; Daantjes, Erna; Matroos, Glenn E; Hoek, Hans W; van Harten, Peter N (Oxford University Press, 2022-06-21)
    BACKGROUND AND HYPOTHESIS: There is a substantial gap in life expectancy between patients with severe mental illness (SMI) and the general population and it is important to understand which factors contribute to this ...
  • Cross-national harmonization of cognitive measures across HRS HCAP (USA) and LASI-DAD (India) 
    Vonk, Jet M J; Gross, Alden L; Zammit, Andrea R; Bertola, Laiss; Avila, Justina F; Jutten, Roos J; Gaynor, Leslie S; Suemoto, Claudia K; Kobayashi, Lindsay C; O'Connell, Megan E; Elugbadebo, Olufisayo; Amofa, Priscilla A; Staffaroni, Adam M; Arce Rentería, Miguel; Turney, Indira C; Jones, Richard N; Manly, Jennifer J; Lee, Jinkook; Zahodne, Laura B (Public Library of Science, 2022-02-25)
    BACKGROUND: As global populations age, cross-national comparisons of cognitive health and dementia risk are increasingly valuable. It remains unclear, however, whether country-level differences in cognitive function are ...
  • Consideration of sex and gender in Alzheimer's disease and related disorders from a global perspective 
    Diversity and Disparity Professional Interest Area Sex and Gender Special Interest Group (John Wiley & Sons Inc., 2022-12)
    Sex or gender differences in the risk of Alzheimer's disease and related dementias (ADRD) differ by world region, suggesting that there are potentially modifiable risk factors for intervention. However, few epidemiological ...
  • Efficacy of the eHealth application Oncokompas, facilitating incurably ill cancer patients to self-manage their palliative care needs: A randomized controlled trial 
    Schuit, Anouk S; Holtmaat, Karen; Lissenberg-Witte, Birgit I; Eerenstein, Simone E J; Zijlstra, Josée M; Eeltink, Corien; Becker-Commissaris, Annemarie; van Zuylen, Lia; van Linde, Myra E; Menke-van der Houven van Oordt, C Willemien; Sommeijer, Dirkje W; Verbeek, Nol; Bosscha, Koop; Tewarie, Rishi Nandoe; Sedee, Robert-Jan; de Bree, Remco; de Graeff, Alexander; de Vos, Filip; Cuijpers, Pim; Verdonck-de Leeuw, Irma M (Elsevier, 2022-07)
    Background: Many patients with incurable cancer have symptoms affecting their health-related quality of life. The eHealth application 'Oncokompas' supports patients to take an active role in managing their palliative care ...
  • SARS-CoV-2 infection in patients with primary Sjögren syndrome: Characterization and outcomes of 51 patients 
    Sjögren Big Data Consortium (Oxford University Press, 2021-06-01)
    Objective: To analyse the prognosis and outcomes of SARS-CoV-2 infection in patients with primary SS. Methods: We searched for patients with primary SS presenting with SARS-CoV-2 infection (defined following and according ...
  • Associations between blood biomarkers, cardiac function and adverse outcome in a young tetralogy of Fallot cohort 
    van den Bosch, Eva; van Genuchten, Wouter J; Luijnenburg, Saskia E; Duppen, Nienke; Kamphuis, Vivian P; Roos-Hesselink, Jolien W; Bartelds, Beatrijs; Roest, Arno A W; Breur, Johannes M P J; Blom, Nico A; Boersma, Eric; Koopman, Laurens P; Helbing, Willem A (Elsevier Ireland Ltd, 2022-08-15)
    BACKGROUND: To determine the potential prognostic value and clinical correlations of blood biomarkers in a cohort of patients with Tetralogy of Fallot (TOF). METHODS: In the setting of multicenter prospective research ...