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UMC Repository: Recent submissions

  • Implementation of Artificial Intelligence in Diagnostic Practice as a Next Step after Going Digital: The UMC Utrecht Perspective 
    Flach, Rachel N.; Fransen, Nina L.; Sonnen, Andreas F.P.; Nguyen, Tri Q.; Breimer, Gerben E.; Veta, Mitko; Stathonikos, Nikolas; van Dooijeweert, Carmen; van Diest, Paul J. (MDPI AG, 2022-04-21)
    Building on a growing number of pathology labs having a full digital infrastructure for pathology diagnostics, there is a growing interest in implementing artificial intelligence (AI) algorithms for diagnostic purposes. ...
  • Hospital variation in treatment patterns and oncological outcomes for patients with muscle-invasive and metastatic bladder cancer in the Netherlands 
    Reesink, Daan J.; van de Garde, Ewoudt M.W.; van der Nat, Paul; Somford, Diederik M.; Los, Maartje; Horenblas, Simon; van Melick, Harm H.E.; Biesma, D. H.; Stijns, P. E.F.; Lavalaye, J.; De Bruin, P. C.; Peters, B. J.M.; Berends, M.; Richardson, R.; Van Andel, J.; Klaver, O. S.; Haberkorn, B. C.M.; Van Rooijen, J. M.; Korthorst, R. A.; Meijer, R. P.; Van der Voort Van Zyp, J. R.N.; for the Santeon MIBC Study Group (Springer-Verlag, 2022-06)
    Purpose: Population-based studies on treatment patterns in oncology and corresponding clinical outcomes can help identify strategies towards optimal value for patients. This study was performed to describe the variation ...
  • Differential Survival and Therapy Benefit of Patients with Breast Cancer Are Characterized by Distinct Epithelial and Immune Cell Microenvironments 
    Kester, Lennart; Seinstra, Danielle; van Rossum, Annelot G.J.; Vennin, Claire; Hoogstraat, Marlous; van der Velden, Daphne; Opdam, Mark; van Werkhoven, Erik; Hahn, Kerstin; Nederlof, Iris; Lips, Ester H.; Mandjes, Ingrid A.M.; van Leeuwen-Stok, A. Elise; Canisius, Sander; van Tinteren, Harm; Imholz, Alex L.T.; Portielje, Johanneke E.A.; Bos, Monique E.M.M.; Bakker, Sandra D.; Rutgers, Emiel J.; Horlings, Hugo M.; Wesseling, Jelle; Voest, Emile E.; Wessels, Lodewyk F.A.; Kok, Marleen; Oosterkamp, Hendrika M.; van Oudenaarden, Alexander; Linn, Sabine C.; van Rheenen, Jacco (American Association for Cancer Research Inc., 2022-03-01)
    Purpose: Extensive work in preclinical models has shown that microenvironmental cells influence many aspects of cancer cell behavior, including metastatic potential and their sensitivity to therapeutics. In the human ...
  • Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma 
    Hosein, Abdel Nasser; Dangol, Gita; Okumura, Takashi; Roszik, Jason; Rajapakshe, Kimal; Siemann, Megan; Zaid, Mohamed; Ghosh, Bidyut; Monberg, Maria; Guerrero, Paola A.; Singhi, Aatur; Haymaker, Cara L.; Clevers, Hans; Abou-Elkacem, Lotfi; Woermann, Sonja M.; Maitra, Anirban (W.B. Saunders, 2022-04)
    Background & Aims: RNF43 is an E3 ubiquitin ligase that is recurrently mutated in pancreatic ductal adenocarcinoma (PDAC) and precursor cystic neoplasms of the pancreas. The impact of RNF43 mutations on PDAC is poorly ...
  • Cancer Induces a Stress Ileopathy Depending on beta-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis 
    Yonekura, Satoru; Terrisse, Safae; Silva, Carolina Alves Costa; Lafarge, Antoine; Iebba, Valerio; Ferrere, Gladys; Goubet, Anne Gaëlle; Fahrner, Jean Eudes; Lahmar, Imran; Ueda, Kousuke; Mansouri, Gibrail; Pizzato, Eugénie; Ly, Pierre; Mazzenga, Marine; Thelemaque, Cassandra; Fidelle, Marine; Jaulin, Fanny; Cartry, Jérôme; Deloger, Marc; Aglave, Marine; Droin, Nathalie; Opolon, Paule; Puget, Angélique; Mann, Fanny; Neunlist, Michel; Bessard, Anne; Aymeric, Laetitia; Matysiak-Budnik, Tamara; Bosq, Jacques; Hofman, Paul; Duong, Connie P.M.; Ugolini, Sophie; Quiniou, Valentin; Berrard, Sylvie; Ryffel, Bernhard; Kepp, Oliver; Kroemer, Guido; Routy, Bertrand; Lordello, Leonardo; Bani, Mohamed Amine; Segata, Nicola; Yengej, Fjodor Yousef; Clevers, Hans; Scoazec, Jean Yves; Pasolli, Edoardo; Derosa, Lisa; Zitvogel, Laurence (American Association for Cancer Research Inc., 2022-04-01)
    Gut dysbiosis has been associated with intestinal and extraintestinal malignancies, but whether and how carcinogenesis drives compositional shifts of the microbiome to its own benefit remains an open conundrum. Here, we ...
  • Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR x LGR5 bispecific antibody with efficacy in epithelial tumors 
    Herpers, Bram; Eppink, Berina; James, Mark I.; Cortina, Carme; Cañellas-Socias, Adrià; Boj, Sylvia F.; Hernando-Momblona, Xavier; Glodzik, Dominik; Roovers, Rob C.; van de Wetering, Marc; Bartelink-Clements, Carina; Zondag-van der Zande, Vanessa; Mateos, Jara García; Yan, Kuan; Salinaro, Lucia; Basmeleh, Abdul; Fatrai, Szabolcs; Maussang, David; Lammerts van Bueren, Jeroen J.; Chicote, Irene; Serna, Garazi; Cabellos, Laia; Ramírez, Lorena; Nuciforo, Paolo; Salazar, Ramon; Santos, Cristina; Villanueva, Alberto; Stephan-Otto Attolini, Camille; Sancho, Elena; Palmer, Hector G.; Tabernero, Josep; Stratton, Michael R.; de Kruif, John; Logtenberg, Ton; Clevers, Hans; Price, Leo S.; Vries, Robert G.J.; Batlle, Eduard; Throsby, Mark (Nature Research, 2022-04)
    Patient-derived organoids (PDOs) recapitulate tumor architecture, contain cancer stem cells and have predictive value supporting personalized medicine. Here we describe a large-scale functional screen of dual-targeting ...
  • Role of the cellular factor CTCF in the regulation of bovine leukemia virus latency and three-dimensional chromatin organization 
    Bellefroid, Maxime; Rodari, Anthony; Galais, Mathilde; Krijger, Peter H.L.; Tjalsma, Sjoerd J.D.; Nestola, Lorena; Plant, Estelle; Vos, Erica S.M.; Cristinelli, Sara; Van Driessche, Benoit; Vanhulle, Caroline; Ait-Ammar, Amina; Burny, Arsène; Ciuffi, Angela; De Laat, Wouter; Van Lint, Carine (Oxford University Press, 2022-04-08)
    Bovine leukemia virus (BLV)-induced tumoral development is a multifactorial phenomenon that remains incompletely understood. Here, we highlight the critical role of the cellular CCCTC-binding factor (CTCF) both in the ...
  • Fibro-fatty remodelling in arrhythmogenic cardiomyopathy 
    Kohela, Arwa; van Rooij, Eva (Springer Science and Business Media Deutschland GmbH, 2022-04-19)
    Arrhythmogenic cardiomyopathy (AC) is an inherited disorder characterized by lethal arrhythmias and a risk to sudden cardiac death. A hallmark feature of AC is the progressive replacement of the ventricular myocardium with ...
  • Confirmatory factor analysis including MRI-derived adipose tissues quantification improves associations of metabolic dysregulation to diastolic dysfunction 
    Klarenberg, Hugo; Dekkers, Ilona A; Peeters, Carel F W; de Mutsert, R; Jukema, J Wouter; Rosendaal, Frits R; Leiner, Tim; Gosselink, Mark; Froeling, Martijn; Strijkers, Gustav J; Boekholdt, S Matthijs; Lamb, Hildo J (Elsevier, 2022-06)
    AIMS: To quantify metabolic impairment via a one-factor approach with confirmatory factor analysis (CFA) including MRI-derived visceral and subcutaneous adipose tissues and to associate it with diastolic dysfunction. ...
  • Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage in Young Patients With a History of Migraine 
    van Os, Hendrikus J A; Verbaan, Dagmar; Ruigrok, Ynte M; Dennesen, Paul; Müller, Marcella C A; Coert, Bert A; Vergouwen, Mervyn D I; Wermer, Marieke J H (Lippincott Williams & Wilkins, 2022-06)
    BACKGROUND: Young patients with aneurysmal subarachnoid hemorrhage (aSAH) and a history of migraine may have an increased risk of delayed cerebral ischemia. We investigated this potential association in a prospective cohort ...
  • Cut-off values for low skeletal muscle mass at the level of the third cervical vertebra (C3) in patients with head and neck cancer 
    Chargi, Najiba; Bril, Sandra I.; Smid, Ernst J.; de Jong, Pim A.; De Bree, Remco (AME Publishing Company, 2022-06)
    Background: Low skeletal muscle mass is associated with adverse outcomes in patients with cancer. For patients with head and neck cancer (HNC), skeletal muscle mass is often assessed at the third cervical vertebra on head ...
  • Statistical shape model of the talus bone morphology: A comparison between impinged and nonimpinged ankles 
    Arbabi, Saeed; Weinans, Harrie; Foppen, Wouter; Seevinck, Peter; de Jong, Pim; Sturkenboom, Joran; van Hamersvelt, Robbert; Foppen, Wouter; Arbabi, Vahid (John Wiley & Sons Inc., 2023-01)
    Diagnosis of ankle impingement is performed primarily by clinical examination, whereas medical imaging is used for severity staging and treatment guidance. The association of impingement symptoms with regional three‐dimensional ...
  • Number of Affected Relatives, Age, Smoking, and Hypertension Prediction Score for Intracranial Aneurysms in Persons with a Family History for Subarachnoid Hemorrhage 
    Zuurbier, Charlotte C.M.; Bourcier, Romain; Beaufils, Pacôme Constant Dit; Redon, Richard; Desal, Hubert; Bor, Anne S.E.; Lindgren, Antti E.; Rinkel, Gabriel J.E.; Greving, Jacoba P.; Ruigrok, Ynte M. (Lippincott Williams & Wilkins, 2022-05)
    Background: Persons with a positive family history of aneurysmal subarachnoid hemorrhage are at increased risk of aneurysmal subarachnoid hemorrhage. Preventive screening for intracranial aneurysms (IAs) in these persons ...
  • Correction to: Increased 30-day mortality in very old ICU patients with COVID-19 compared to patients with respiratory failure without COVID-19 (Intensive Care Medicine, (2022), 48, 4, (435-447), 10.1007/s00134-022-06642-z) 
    Guidet, Bertrand; Jung, Christian; Flaatten, Hans; Fjolner, Jesper; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Beil, Michael; Sigal, Sviri; van Heerden, Peter Vernon; Szczeklik, Wojciech; Joannidis, Michael; Oeyen, Sandra; Kondili, Eumorfia; Marsh, Brian; Andersen, Finn H.; Moreno, Rui; Cecconi, Maurizio; Leaver, Susannah; De lange, Dylan W.; Boumendil, Ariane (Springer-Verlag, 2022-06)
    There is a mistake in the list of participating countries and ICUs listed in the Acknowledgement section. The Publisher apologizes for this mistake. Additionally, the correct full name of Alex Cornet is Alexander Daniel ...
  • Pooled Population Pharmacokinetic Analysis for Exploring Ciprofloxacin Pharmacokinetic Variability in Intensive Care Patients 
    Dutch Antibiotic PK/PD Collaborators (Adis, 2022-06)
    BACKGROUND AND OBJECTIVE: Previous pharmacokinetic (PK) studies of ciprofloxacin in intensive care (ICU) patients have shown large differences in estimated PK parameters, suggesting that further investigation is needed for ...
  • Geriatric Falls: A Registry-Based Study in the Netherlands 
    Verbeek, Frank H.O.; Ham, Wietske H.W.; Verbeek, André L.M.; de Man-van Ginkel, Janneke M.; van Os-Medendorp, Harmieke; Westers, Paul; Leenen, Luke P.H. (Lippincott Williams & Wilkins, 2022-05-01)
    BACKGROUND: Falls in people 65 years and older evaluated in the emergency department are increasing. Of all unintentional injury-related deaths among older people, 55% are due to falls. The impact of falls, especially ...
  • Variations in Clinical Practice: Assessing Clinical Care Processes According to Clinical Guidelines in a National Cohort of Hospice Patients 
    de Graaf, Everlien; Grant, Matthew; van de Baan, Frederieke; Ausems, Marijke; Verboeket-Crul, Cathelijne; Leget, Carlo; Teunissen, Saskia (Sage Publications, 2023-01)
    Background: National clinical guidelines have been developed internationally to reduce variations in clinical practices and promote the quality of palliative care. In The Netherlands, there is considerable variability in ...
  • Short-term mortality of patients ≥80 years old admitted to European intensive care units: an international observational study 
    VIP1 & VIP2 study group (Oxford University Press, 2022-07)
    BACKGROUND: Limited evidence suggests variation in mortality of older critically ill adults across Europe. We aimed to investigate regional differences in mortality among very old ICU patients. METHODS: Multilevel analysis ...
  • Phase III trial of chemoradiotherapy with temozolomide plus nivolumab or placebo for newly diagnosed glioblastoma with methylated MGMT promoter 
    Lim, Michael; Weller, Michael; Idbaih, Ahmed; Steinbach, Joachim; Finocchiaro, Gaetano; Raval, Raju R; Ansstas, George; Baehring, Joachim; Taylor, Jennie W; Honnorat, Jerome; Petrecca, Kevin; De Vos, Filip; Wick, Antje; Sumrall, Ashley; Sahebjam, Solmaz; Mellinghoff, Ingo K; Kinoshita, Masashi; Roberts, Mustimbo; Slepetis, Ruta; Warad, Deepti; Leung, David; Lee, Michelle; Reardon, David A; Omuro, Antonio (Oxford University Press, 2022-11-02)
    BACKGROUND: Nearly all patients with newly diagnosed glioblastoma experience recurrence following standard-of-care radiotherapy (RT) + temozolomide (TMZ). The purpose of the phase III randomized CheckMate 548 study was to ...
  • Opportunities and Challenges for Decentralized Clinical Trials: European Regulators' Perspective 
    Trials@Home Consortium (Wiley-Blackwell, 2022-08)
    Decentralized clinical trials (DCTs) have the potential to improve accessibility, diversity, and retention in clinical trials by moving trial activities to participants' homes and local surroundings. In this study, we ...