Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

Now showing items 12701-12720 of 40729

Explainable artificial intelligence (XAI) in deep learning-based medical image analysis

van der Velden, Bas H M; Kuijf, Hugo J; Gilhuijs, Kenneth G A; Viergever, Max A (Elsevier, 2022-07)

With an increase in deep learning-based methods, the call for explainability of such methods grows, especially in high-stakes decision making areas such as medical image analysis. This survey presents an overview of ...
Microinfarcts in the Deep Gray Matter on 7T MRI: Risk Factors, MRI Correlates, and Relation to Cognitive Functioning-The SMART-MR Study

Ghaznawi, R; Zwartbol, M H T; de Bresser, J; Kuijf, H J; Vincken, K L; Rissanen, I; Geerlings, M I; Hendrikse, J; UCC-SMART Study Group (American Society of Neuroradiology, 2022-06)

BACKGROUND AND PURPOSE: The clinical relevance of cortical microinfarcts has recently been established; however, studies on microinfarcts in the deep gray matter are lacking. We examined the risk factors and MR imaging ...
Multifaceted Activities of Seven Nanobodies against Complement C4b

De la O Becerra, Karla I.; Oosterheert, Wout; van den Bos, Ramon M.; Xenaki, Katerina T.; Lorent, Joseph H.; Ruyken, Maartje; Schouten, Arie; Rooijakkers, Suzan H.M.; van Bergen En Henegouwen, Paul M.P.; Gros, Piet (American Association of Immunologists, 2022-05-01)

Cleavage of the mammalian plasma protein C4 into C4b initiates opsonization, lysis, and clearance of microbes and damaged host cells by the classical and lectin pathways of the complement system. Dysregulated activation ...
Natural Human Immunity Against Staphylococcal Protein A Relies on Effector Functions Triggered by IgG3

Boero, Elena; Cruz, Ana Rita; Pansegrau, Werner; Giovani, Cinzia; Rooijakkers, Suzan H.M.; van Kessel, Kok P.M.; van Strijp, Jos A.G.; Bagnoli, Fabio; Manetti, Andrea G.O. (Frontiers Media S. A., 2022-03-11)

Staphylococcal protein A (SpA) is a multifunctional, highly conserved virulence factor of Staphylococcus aureus. By binding the Fc portion of all human IgG subclasses apart from IgG3, SpA interferes with antibody and ...
Exposure to the Amino Acids Histidine, Lysine, and Threonine Reduces mTOR Activity and Affects Neurodevelopment in a Human Cerebral Organoid Model

Berdenis van Berlekom, Amber; Kübler, Raphael; Hoogeboom, Jeske W; Vonk, Daniëlle; Sluijs, Jacqueline A; Pasterkamp, R Jeroen; Middeldorp, Jinte; Kraneveld, Aletta D; Garssen, Johan; Kahn, René S; Hol, Elly M; de Witte, Lot D; Boks, Marco P (Multidisciplinary Digital Publishing Institute (MDPI), 2022-05-02)

Evidence of the impact of nutrition on human brain development is compelling. Previous in vitro and in vivo results show that three specific amino acids, histidine, lysine, and threonine, synergistically inhibit mTOR ...
Sutureless versus Hand-Sewn Coronary Anastomoses: A Systematic Review and Meta-Analysis

Hoogewerf, Marieke; Schuurkamp, Jeroen; Kelder, Johannes C.; Jacobs, Stephan; Doevendans, Pieter A. (Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-29)

Background: Sutureless coronary anastomotic devices are intended to facilitate minimally invasive coronary artery bypass grafting (MICS-CABG) by easing and eventually standardizing the anastomotic technique. Within this ...
Echocardiographic Deformation Imaging for Early Detection of Genetic Cardiomyopathies: JACC Review Topic of the Week

Taha, Karim; Kirkels, Feddo P.; Teske, Arco J.; Asselbergs, Folkert W.; van Tintelen, J. Peter; Doevendans, Pieter A.; Kutty, Shelby; Haugaa, Kristina H.; Cramer, Maarten J. (Elsevier, 2022-02-15)

Clinical screening of the relatives of patients with genetic cardiomyopathies is challenging, as they often lack detectable cardiac abnormalities at presentation. Life-threatening adverse events can already occur in these ...
Generation of human induced pluripotent stem cell (iPSC) lines derived from five patients carrying the pathogenic phospholamban-R14del (PLN-R14del) variant and three non-carrier family members

Mittal, Nishka; Dave, Jaydev; Harakalova, Magdalena; van Tintelen, J. Peter; Asselbergs, Folkert W.; Doevendans, Pieter A.; Costa, Kevin D.; Turnbull, Irene C.; Stillitano, Francesca (Elsevier, 2022-04)

The R14del pathogenic variant in the phospholamban (PLN) gene (PLN-R14del), has been identified in families with hereditary cardiomyopathy, including dilated and arrhythmogenic cardiomyopathies. Here we have generated human ...
Follistatin-like 1 promotes proliferation of matured human hypoxic iPSC-cardiomyocytes and is secreted by cardiac fibroblasts

Peters, Marijn C.; Di Martino, Sofia; Boelens, Thomas; Qin, Jiabin; van Mil, Alain; Doevendans, Pieter A.; Chamuleau, Steven A.J.; Sluijter, Joost P.G.; Neef, Klaus (Cell Press, 2022-06-09)

The human heart has limited regenerative capacity. Therefore, patients often progress to heart failure after ischemic injury, despite advances in reperfusion therapies generally decreasing mortality. Depending on its ...
Will our cardiomyopathy patients accept gene therapy?

Doevendans, P. A.; Kupatt, C.; Giacca, M.; Glijnis, P. (Bohn Stafleu van Loghum, 2022-07)

Novel techniques such as gene therapy are becoming available in an attempt to cure inherited diseases. Before these new therapies can be offered to patients, we need to be aware of potential reservations or objections, not ...
NSTEMI with total left circumflex occlusion: How the N-wave might help (case report)

Alsagaff, Mochamad Yusuf; Wardhani, Louisa Fadjri Kusuma; Pratanu, Iswanto; Kartikasari, Dian Paramita; Doevendans, Pieter A. (Oxford University Press, 2022-02)

A rise and/or fall in troponin level is an indication of type 1 or 2 myocardial infarct. A 62-year-old male physician presented to emergency room with chest discomfort followed by thought to be normal electrocardiogram ...
Preclinical Comparison of Distal Off-Pump Anastomotic Remodeling: Hand-Sewn Versus ELANA Heart Bypass

Stecher, David; Hoogewerf, Marieke; van Putte, Bart P.; Osman, Shadan; Doevendans, Pieter A.; Tulleken, Cornelis; van Herwerden, Lex; Pasterkamp, Gerard; Buijsrogge, Marc P. (Lippincott Williams & Wilkins, 2022-03-18)

Objective: The ELANA Heart Bypass System is a new sutureless technique for coronary anastomoses. A titanium clip connects the graft with the coronary artery, whereafter the arteriotomy is performed by excimer laser. Since ...
Modifiable risk factors in adults with and without prior cardiovascular disease: findings from the Indonesian National Basic Health Research

Arsyad, Dian Sidik; Westerink, Jan; Cramer, Maarten J.; Ansar, Jumriani; Wahiduddin; Visseren, Frank L.J.; Doevendans, Pieter A.; Ansariadi (BioMed Central, 2022-04-05)

Backgrounds: The majority of risk factors for cardiovascular diseases (CVDs) are modifiable. Continuous monitoring and control of these factors could significantly reduce the risk of CVDs-related morbidity and mortality. ...
Revascularization strategies for patients with established chronic coronary syndrome

Coerkamp, Casper F.; Hoogewerf, Marieke; van Putte, Bart P.; Appelman, Yolande; Doevendans, Pieter A. (Wiley-Blackwell, 2022-08)

Coronary artery disease is the most common type of cardiovascular disease, leading to high mortality rates worldwide. Although the vast majority can be treated effectively and safely by medical therapy, revascularization ...
Safety and feasibility study of non-invasive robot-assisted high-intensity focused ultrasound therapy for the treatment of atherosclerotic plaques in the femoral artery: protocol for a pilot study

Simons, Michelle V.; Groen, Marijn H.A.; de Borst, Gert J.; Leiner, Tim; Doevendans, Pieter A.F.; Ebbini, Emad; Slieker, Fons J.B.; van Es, René; Hazenberg, Constantijn E.V.B. (BMJ Publishing Group, 2022-05-02)

Introduction Peripheral arterial disease (PAD) is an atherosclerotic disease leading to stenosis and/or occlusion of the arterial circulation of the lower extremities. The currently available revascularisation methods have ...
Current and future diagnostic and treatment strategies for patients with invasive lobular breast cancer

Van Baelen, K; Geukens, T; Maetens, M; Tjan-Heijnen, V; Lord, C J; Linn, S; Bidard, F-C; Richard, F; Yang, W W; Steele, R E; Pettitt, S J; Van Ongeval, C; De Schepper, M; Isnaldi, E; Nevelsteen, I; Smeets, A; Punie, K; Voorwerk, L; Wildiers, H; Floris, G; Vincent-Salomon, A; Derksen, P W B; Neven, P; Senkus, E; Sawyer, E; Kok, M; Desmedt, C (Oxford University Press, 2022-08)

BACKGROUND: Invasive lobular breast cancer (ILC) is the second most common type of breast cancer after invasive breast cancer of no special type (NST), representing up to 15% of all breast cancers. DESIGN: Latest data on ...
Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer

Rätze, Max A K; Koorman, Thijs; Sijnesael, Thijmen; Bassey-Archibong, Blessing; van de Ven, Robert; Enserink, Lotte; Visser, Daan; Jaksani, Sridevi; Viciano, Ignacio; Bakker, Elvira R M; Richard, François; Tutt, Andrew; O'Leary, Lynda; Fitzpatrick, Amanda; Roca-Cusachs, Pere; van Diest, Paul J; Desmedt, Christine; Daniel, Juliet M; Isacke, Clare M; Derksen, Patrick W B (Nature Publishing Group, 2022-05-20)

Invasive lobular breast carcinoma (ILC) is characterized by proliferative indolence and long-term latency relapses. This study aimed to identify how disseminating ILC cells control the balance between quiescence and cell ...
Correction: Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer

Rätze, Max A K; Koorman, Thijs; Sijnesael, Thijmen; Bassey-Archibong, Blessing; van de Ven, Robert; Enserink, Lotte; Visser, Daan; Jaksani, Sridevi; Viciano, Ignacio; Bakker, Elvira R M; Richard, François; Tutt, Andrew; O'Leary, Lynda; Fitzpatrick, Amanda; Roca-Cusachs, Pere; van Diest, Paul J; Desmedt, Christine; Daniel, Juliet M; Isacke, Clare M; Derksen, Patrick W B (Nature Publishing Group, 2022-06-24)

Following the publication of this article, the authors noted an error in Fig. 6C. The merged (bottom left) panel for the human ILC organoid KCL320, did not display the correct z-plane. The correct merged image has now been ...
Genetic, biochemical, and clinical spectrum of patients with mitochondrial trifunctional protein deficiency identified after the introduction of newborn screening in the Netherlands

Schwantje, Marit; Fuchs, Sabine A.; de Boer, Lonneke; Bosch, Annet M.; Cuppen, Inge; Dekkers, Eugenie; Derks, Terry G.J.; Ferdinandusse, Sacha; Ijlst, Lodewijk; Houtkooper, Riekelt H.; Maase, Rose; van der Pol, W. Ludo; de Vries, Maaike C.; Verschoof-Puite, Rendelien K.; Wanders, Ronald J.A.; Williams, Monique; Wijburg, Frits; Visser, Gepke (Springer Netherlands, 2022-07)

Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) is included in many newborn screening (NBS) programs. Acylcarnitine-based NBS for LCHADD not only identifies LCHADD, but also the other deficiencies of the ...
Thermo-sensitive mitochondrial trifunctional protein deficiency presenting with episodic myopathy

Schwantje, Marit; Ebberink, Merel S.; Doolaard, Mirjam; Ruiter, Jos P.N.; Fuchs, Sabine A.; Darin, Niklas; Hedberg-Oldfors, Carola; Régal, Luc; Donker Kaat, Laura; Huidekoper, Hidde H.; Olpin, Simon; Cole, Duncan; Moat, Stuart J.; Visser, Gepke; Ferdinandusse, Sacha (Springer Netherlands, 2022-07)

Mitochondrial trifunctional protein (MTP) is involved in long-chain fatty acid β-oxidation (lcFAO). Deficiency of one or more of the enzyme activities as catalyzed by MTP causes generalized MTP deficiency (MTPD), long-chain ...

Now showing items 12701-12720 of 40729