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  • Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression 
    COMPASS study group (Massachussetts Medical Society, 2022-11-03)
    BACKGROUND Psilocybin is being studied for use in treatment-resistant depression. METHODS In this phase 2 double-blind trial, we randomly assigned adults with treatmentresistant depression to receive a single dose of a ...
  • Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature 
    van Jaarsveld, Richard H; Reilly, Jack; Cornips, Marie-Claire; Hadders, Michael A; Agolini, Emanuele; Ahimaz, Priyanka; Anyane-Yeboa, Kwame; Bellanger, Severine Audebert; van Binsbergen, Ellen; van den Boogaard, Marie-Jose; Brischoux-Boucher, Elise; Caylor, Raymond C; Ciolfi, Andrea; van Essen, Ton A J; Fontana, Paolo; Hopman, Saskia; Iascone, Maria; Javier, Margaret M; Kamsteeg, Erik-Jan; Kerkhof, Jennifer; Kido, Jun; Kim, Hyung-Goo; Kleefstra, Tjitske; Lonardo, Fortunato; Lai, Abbe; Lev, Dorit; Levy, Michael A; Lewis, M E Suzanne; Lichty, Angie; Mannens, Marcel M A M; Matsumoto, Naomichi; Maya, Idit; McConkey, Haley; Megarbane, Andre; Michaud, Vincent; Miele, Evelina; Niceta, Marcello; Novelli, Antonio; Onesimo, Roberta; Pfundt, Rolph; Popp, Bernt; Prijoles, Eloise; Relator, Raissa; Redon, Sylvia; Rots, Dmitrijs; Rouault, Karen; Saida, Ken; Schieving, Jolanda; Tartaglia, Marco; Tenconi, Romano; Uguen, Kevin; Verbeek, Nienke; Walsh, Christopher A; Yosovich, Keren; Yuskaitis, Christopher J; Zampino, Giuseppe; Sadikovic, Bekim; Alders, Mariëlle; Oegema, Renske (Lippincott Williams & Wilkins, 2023-01)
    PURPOSE: Pathogenic variants in genes involved in the epigenetic machinery are an emerging cause of neurodevelopment disorders (NDDs). Lysine-demethylase 2B (KDM2B) encodes an epigenetic regulator and mouse models suggest ...
  • The effect of nasal Staphylococcus aureus colonization and antibiotic treatment on disease activity in ANCA-associated vasculitis: a retrospective cohort study in the Netherlands 
    Schaap, Caroline M.; Krol, Roline M.; Remmelts, Hilde H.F.; Klaasen, Ruth; Hagen, E. Christiaan; Spierings, Julia; Heijstek, Marloes W. (Springer-Verlag, 2023-03)
    The aim of this study was to identify the role of nasal Staphylococcus aureus (S. aureus) colonization and the effect of systemic or local antibiotic treatment on disease activity in patients with antineutrophil cytoplasmic ...
  • Circle of Willis variation and outcome after intra-arterial treatment 
    Rozeman, Anouk; Hund, Hajo; Boiten, Jelis; Vos, Jan Albert; Schonewille, Wouter; Wermer, Marieke; Lycklama A Nijeholt, Geert; Algra, Ale (BMJ Publishing Group, 2022-09-20)
    Background Intra-arterial treatment (IAT) improves outcomes in acute ischaemic stroke. Presence of collaterals increases likelihood of good outcome. We investigated whether variations in the circle of Willis (CoW) and ...
  • Child maltreatment, migration and risk of first-episode psychosis: results from the multinational EU-GEI study 
    D'Andrea, Giuseppe; Lal, Jatin; Tosato, Sarah; Gayer-Anderson, Charlotte; Jongsma, Hannah E; Stilo, Simona A; van der Ven, Els; Quattrone, Diego; Velthorst, Eva; Berardi, Domenico; Rossi Menezes, Paulo; Arango, Celso; Parellada, Mara; Lasalvia, Antonio; La Cascia, Caterina; Ferraro, Laura; La Barbera, Daniele; Sideli, Lucia; Bobes, Julio; Bernardo, Miguel; Sanjuán, Julio; Santos, Jose Luis; Arrojo, Manuel; Del-Ben, Cristina Marta; Tripoli, Giada; Llorca, Pierre-Michel; de Haan, Lieuwe; Selten, Jean-Paul; Tortelli, Andrea; Szöke, Andrei; Muratori, Roberto; Rutten, Bart P; van Os, Jim; Jones, Peter B; Kirkbride, James B; Murray, Robin M; di Forti, Marta; Tarricone, Ilaria; Morgan, Craig (Cambridge University Press, 2023-10-28)
    BACKGROUND: Child maltreatment (CM) and migrant status are independently associated with psychosis. We examined prevalence of CM by migrant status and tested whether migrant status moderated the association between CM and ...
  • Head-to-head comparison of the accuracy of saliva and nasal rapid antigen SARS-CoV-2 self-testing: cross-sectional study 
    Schuit, Ewoud; Venekamp, Roderick P.; Veldhuijzen, Irene K.; van den Bijllaardt, Wouter; Pas, Suzan D.; Stohr, Joep J.J.M.; Lodder, Esther B.; Hellwich, Marloes; Molenkamp, Richard; Igloi, Zsofia; Wijers, Constantijn; Vroom, Irene H.; Nagel-Imming, Carla R.S.; Han, Wanda G.H.; Kluytmans, Jan A.J.W.; van den Hof, Susan; van de Wijgert, Janneke H.H.M.; Moons, Karel G.M. (BioMed Central Ltd., 2022-10-24)
    Background: The diagnostic accuracy of unsupervised self-testing with rapid antigen diagnostic tests (Ag-RDTs) is mostly unknown. We studied the diagnostic accuracy of a self-performed SARS-CoV-2 saliva and nasal Ag-RDT ...
  • SARS-CoV-2 Alpha-Variant Outbreak Amongst a Partially Vaccinated Long-Term Care Facility Population in The Netherlands—Phylogenetic Analysis and Infection Control Observations 
    Van der Moeren, Nathalie; Weterings, Veronica A.T.C.; Pas, Suzan D.; Verweij, Jaco J.; van den Bijllaardt, Wouter; Geurts, Joyce; Zwart, Vivian F.; Lodder, Esther B.; Kluytmans, Jan A.J.W.; Murk, Jean Luc; Stohr, Joep J.J.M. (MDPI AG, 2022-10)
    Despite extensive vaccination and booster programs, SARS-CoV-2 outbreaks in long-term care facilities (LTCF) continue to occur. We retrospectively describe a SARS-CoV-2 outbreak amongst a partially vaccinated LTCF population ...
  • 3D Human iPSC Blood Vessel Organoids as a Source of Flow-Adaptive Vascular Cells for Creating a Human-Relevant 3D-Scaffold Based Macrovessel Model 
    Meijer, Elana M; Koch, Suzanne E; van Dijk, Christian G M; Maas, Renee G C; Chrifi, Ihsan; Szymczyk, Wojciech; Besseling, Paul J; Pomp, Lisa; Koomen, Vera J C H; Buikema, Jan Willem; Bouten, Carlijn V C; Verhaar, Marianne C; Smits, Anthal I P M; Cheng, Caroline (John Wiley & Sons Inc., 2023-01)
    3D-scaffold based in vitro human tissue models accelerate disease studies and screening of pharmaceutics while improving the clinical translation of findings. Here is reported the use of human induced pluripotent stem cell ...
  • Four decades of experience with carcinoid heart disease: An analysis of 84 patients 
    Levy, Sonja; Korse, Catherina E; de Groot, Andre C A; Meijer, Ronald C A; Tesselaar, Margot E T; Valk, Gerlof D (Wiley-Blackwell, 2022-10)
    Carcinoid heart disease (CHD) is a serious cardiac condition which is caused by elevated serotonin in the systemic circulation, secreted by neuroendocrine tumours (NET). It mostly affects the right-sided heart valves, where ...
  • Complement component C3 and C5b-9 deposition on hypoxia reperfused endothelial cells by non-HLA antibodies against RhoGDI2: A player involved in graft failure? 
    Kardol-Hoefnagel, Tineke; Michielsen, Laura A; Ehlers, Anna M; van Zuilen, Arjan D; Luijk, Bart; Otten, Henny G (Wiley-Blackwell, 2023-02)
    Antibodies against Rho GDP-dissociation inhibitor 2 (RhoGDI2) are associated with inferior graft survival in transplant patients receiving a kidney from deceased donors. Although this suggests that these antibodies contribute ...
  • Risk Factors for Perioperative Brain Lesions in Infants With Congenital Heart Disease: A European Collaboration 
    Bonthrone, Alexandra F; Stegeman, Raymond; Feldmann, Maria; Claessens, Nathalie H P; Nijman, Maaike; Jansen, Nicolaas J G; Nijman, Joppe; Groenendaal, Floris; de Vries, Linda S; Benders, Manon J N L; Haas, Felix; Bekker, Mirielle N; Logeswaran, Thushiha; Reich, Bettina; Kottke, Raimund; Hagmann, Cornelia; Latal, Beatrice; Dave, Hitendu; Simpson, John; Pushparajah, Kuberan; Austin, Conal; Kelly, Christopher J; Arulkumaran, Sophie; Rutherford, Mary A; Counsell, Serena J; Knirsch, Walter; Breur, Johannes M P J (Lippincott Williams & Wilkins, 2022-12)
    Background: Infants with congenital heart disease are at risk of brain injury and impaired neurodevelopment. The aim was to investigate risk factors for perioperative brain lesions in infants with congenital heart disease. ...
  • Do we become better prescribers after graduation: A 1-year international follow-up study among junior doctors 
    Donker, Erik M.; Brinkman, David J.; van Rosse, Floor; Janssen, Ben; Knol, Wilma; Dumont, Glenn; Jorens, Philippe G.; Dupont, Alain; Christiaens, Thierry; van Smeden, Jeroen; de Waard-Siebinga, Itte; Peeters, Laura E.J.; Goorden, Ronald; Hessel, Marleen; Lissenberg-Witte, Birgit; Richir, Milan; van Agtmael, Michiel A.; Kramers, Cornelis; Tichelaar, Jelle; the Education committee of the Dutch Society for Clinical Pharmacology and Biopharmacy (Wiley-Blackwell, 2022-12)
    AIM: The aim of this study was to investigate how the prescribing knowledge and skills of junior doctors in the Netherlands and Belgium develop in the year after graduation. We also analysed differences in knowledge and ...
  • A Systematic Review of the Current Evidence from Randomised Controlled Trials on the Impact of Medication Optimisation or Pharmacological Interventions on Quantitative Measures of Cognitive Function in Geriatric Patients 
    Pazan, Farhad; Petrovic, Mirko; Cherubini, Antonio; Cruz-Jentoft, Alfonso J.; Denkinger, Michael; van der Cammen, Tischa J.M.; Stevenson, Jennifer M.; Ibrahim, Kinda; Rajkumar, Chakravarthi; Bakken, Marit Stordal; Crome, Peter; Guðmundsson, Adalsteinn; Knol, Wilma; Snijders, Birgitta M.G.; O’Mahony, Denis; Serra-Rexach, José Antonio; Soulis, George; van Marum, Rob J.; Ziere, Gijsbertus; Mair, Alpana; Burkhardt, Heinrich; Neumann-Podczaska, Agnieszka; Wieczorowska-Tobis, Katarzyna; Fernandes, Marilia Andreia; Gruner, Heidi; van der Velde, Nathalie; Wehling, Martin (Adis, 2022-11)
    Background: Cognitive decline is common in older people. Numerous studies point to the detrimental impact of polypharmacy and inappropriate medication on older people’s cognitive function. Here we aim to systematically ...
  • The course of pain and dysphagia after radiofrequency ablation for Barrett's esophagus-related neoplasia 
    Overwater, Anouk; Elias, Sjoerd G.; Schoon, Erik J.; Bergman, Jacques J.G.H.M.; Pouw, Roos E.; Weusten, Bas L.A.M. (Georg Thieme Verlag, 2023-03)
    BACKGROUND:  Radiofrequency ablation (RFA) is effective for eradication of Barrett's esophagus (BE) neoplasia, but little is known on the course of pain and dysphagia after RFA. We aimed to describe the course of post-RFA ...
  • Erratum: Impact of expert center endoscopic assessment of confirmed low grade dysplasia in Barrett's esophagus diagnosed in community hospitals (Endoscopy DOI: 10.1055/a-1754-7309) 
    Nieuwenhuis, Esther A.; Van Munster, Sanne N.; Curvers, Wouter L.; Weusten, Bas L.A.M.; Alvarez Herrero, Lorenza; Bogte, Auke; Alkhalaf, Alaa; Schenk, B. Ed; Koch, Arjun D.; Spaander, Manon C.W.; Tang, Thjon J.; Nagengast, Wouter B.; Westerhof, Jessie; Houben, Martin H.M.G.; Bergman, Jacques J.G.H.M.; Schoon, Erik J.; Pouw, Roos E. (Georg Thieme Verlag, 2022-10-01)
    In the above-mentioned article, the title has been corrected. Correct is: Impact of expert center endoscopic assessment of confirmed low grade dysplasia in Barrett s esophagus diagnosed in community hospitals.. This was ...
  • Wide-area transepithelial sampling with computer-assisted analysis to detect high grade dysplasia and cancer in Barrettʼs esophagus: A Multi-Center, Randomized Study 
    Van Munster, Sanne; Leclercq, Philippe; Haidry, Rehan; Messmann, Helmut; Probst, Andreas; Ragunath, Krish; Bhandari, Pradeep; Repici, Alessandro; Munoz-Navas, Miguel; Seewald, Stefan; Lemmers, Arnaud; Fernández-Esparrach, Glòria; Pech, Oliver; Schoon, Erik J.; Kariv, Revital; Neuhaus, Horst; Weusten, Bas L.A.M.; Siersema, Peter D.; Correale, Loredana; Meijer, Sybren L.; De Hertogh, Gert; Bergman, Jacques Jghm; Hassan, Cesare; Bisschops, Raf (Georg Thieme Verlag, 2022-05-26)
    BACKGROUND: Current surveillance for Barrett's esophagus (BE), consisting of four-quadrant random forceps biopsies (FBs), has an inherent risk of sampling error. Wide-area transepithelial sampling (WATS) may increase ...
  • Adjuvant capecitabine-containing chemotherapy benefit and homologous recombination deficiency in early-stage triple-negative breast cancer patients 
    de Boo, Leonora W.; Jóźwiak, Katarzyna; Joensuu, Heikki; Lindman, Henrik; Lauttia, Susanna; Opdam, Mark; van Steenis, Charlaine; Brugman, Wim; Kluin, Roelof J.C.; Schouten, Philip C.; Kok, Marleen; Nederlof, Petra M.; Hauptmann, Michael; Linn, Sabine C. (Springer Nature, 2022-06-01)
    Background: The addition of adjuvant capecitabine to standard chemotherapy of early-stage triple-negative breast cancer (TNBC) patients has improved survival in a few randomised trials and in meta-analyses. However, many ...
  • Ten-year follow-up of the observational RASTER study, prospective evaluation of the 70-gene signature in ER-positive, HER2-negative, node-negative, early breast cancer 
    Vliek, Sonja B.; Hilbers, Florentine S.; Jager, Agnes; Retèl, Valesca P.; Bueno de Mesquita, Jolien M.; Drukker, Caroline A.; Veltkamp, Sanne C.; Zeillemaker, Anneke M.; Rutgers, Emiel J.; van Tinteren, Harm; van Harten, Wim H.; van 't Veer, Laura J.; van de Vijver, Marc J.; Linn, Sabine C. (Elsevier Limited, 2022-11)
    Introduction: Prognostic gene expression signatures can be used in combination with classical clinicopathological factors to guide adjuvant chemotherapy decisions in ER-positive, HER2-negative breast cancer. However, ...
  • Daily Oral Ibandronate With Adjuvant Endocrine Therapy in Postmenopausal Women With Estrogen Receptor-Positive Breast Cancer (BOOG 2006-04): Randomized Phase III TEAM-IIB Trial 
    Vliek, Sonja B.; Noordhoek, Iris; Meershoek-Klein Kranenbarg, Elma; Van Rossum, Annelot G.J.; Dezentje, Vincent O.; Jager, Agnes; Hokken, J. W.Esmeralda; Putter, Hein; Van Der Velden, Annette W.G.; Hendriks, Mathijs P.; Bakker, Sandra D.; Van Riet, Yvonne E.A.; Tjan-Heijnen, Vivianne C.G.; Portielje, Johanneke E.A.; Kroep, Judith R.; Nortier, Johan W.R.; Van De Velde, Cornelis J.H.; Linn, Sabine C. (Lippincott Williams & Wilkins, 2022-04-01)
    PURPOSE: For postmenopausal patients with breast cancer, previous subgroup analyses have shown a modest benefit from adjuvant bisphosphonate treatment. However, the efficacy of oral nitrogen-containing bisphosphonates such ...
  • De-escalation of radiotherapy after primary chemotherapy in cT1–2N1 breast cancer (RAPCHEM; BOOG 2010–03): 5-year follow-up results of a Dutch, prospective, registry study 
    de Wild, Sabine R.; de Munck, Linda; Simons, Janine M.; Verloop, Janneke; van Dalen, Thijs; Elkhuizen, Paula H.M.; Houben, Ruud M.A.; van Leeuwen, A. Elise; Linn, Sabine C.; Pijnappel, Ruud M.; Poortmans, Philip M.P.; Strobbe, Luc J.A.; Wesseling, Jelle; Voogd, Adri C.; Boersma, Liesbeth J. (Elsevier Limited, 2022-09)
    Background: Primary chemotherapy in breast cancer poses a dilemma with regard to adjuvant locoregional radiotherapy, as guidelines for locoregional radiotherapy were originally based on pathology results of primary surgery. ...