Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

Now showing items 11541-11560 of 40729

The Dutch list of essential drugs for undergraduate medical education: A modified Delphi study

Donker, Erik M; Pandit, Rahul; Poleij, Merel C S; Brinkman, David J; van Agtmael, Michiel A; van Rosse, Floor; Dumont, Glenn; Kramers, Cornelis; Atiqi, Roya; Richir, Milan C; van Smeden, Jeroen; Hessel, Marleen H M; Janssen, Ben J; Knol, Wilma; Tichelaar, Jelle; Pharmacotherapy Education working group of the Dutch Society for Clinical Pharmacology & Biopharmacy and its affiliated Dutch Network of Clinical Pharmacology Teachers (Wiley-Blackwell, 2023-04)

Aims: Prescribing errors among junior doctors are common in clinical practice because many lack prescribing competence after graduation. This is in part due to inadequate education in clinical pharmacology and therapeutics ...
Prevalence and clinical associations of myositis antibodies in a large cohort of interstitial lung diseases

Moll, Sofia A; Platenburg, Mark G J P; Platteel, Anouk C M; Vorselaars, Adriane D M; Janssen Bonàs, Montse; Kraaijvanger, Raisa; Roodenburg-Benschop, Claudia; Meek, Bob; van Moorsel, Coline H M; Grutters, Jan C (Public Library of Science, 2022-11)

Background Serologic testing for autoantibodies is recommended in interstitial lung diseases (ILDs), as connective tissue diseases (CTDs) are an important secondary cause. Myositis antibodies are associated with CTD-ILD, ...
Progressive Disease With Low Survival in Adult Patients With Pulmonary Fibrosis Carrying Surfactant-Related Gene Mutations: an observational study

Klay, Dymph; Grutters, Jan C; van der Vis, Joanne J; Platenburg, Mark G J P; Kelder, Johannes C; Tromp, Ellen; van Moorsel, Coline H M (Elsevier, 2023-04)

BACKGROUND: In some patients with progressive fibrosing interstitial lung disease (ILD), disease is caused by carriage of a mutation in a surfactant-related gene (SRG) such as SFTPC, SFTPA2, or ABCA3. However, no aggregated ...
Pulmonary Hypertension Associated Genetic Variants in Sarcoidosis Associated Pulmonary Hypertension

Groen, Karlijn; Huitema, Marloes P.; van der Vis, Joanne J.; Post, Marco C.; Grutters, Jan C.; Baughman, Robert P.; van Moorsel, Coline H.M. (MDPI AG, 2022-10-21)

Background: Pulmonary hypertension (PH) is a severe complication of sarcoidosis in a minority of patients. Several genetic defects are known to cause hereditary or sporadic PH, but whether variants in PH-associated genes ...
Snowflake epitope matching correlates with child-specific antibodies during pregnancy and donor-specific antibodies after kidney transplantation

Niemann, Matthias; Strehler, Yara; Lachmann, Nils; Halleck, Fabian; Budde, Klemens; Hönger, Gideon; Schaub, Stefan; Matern, Benedict M; Spierings, Eric (Frontiers Media S. A., 2022-10-28)

Development of donor-specific human leukocyte antigen (HLA) antibodies (DSA) remains a major risk factor for graft loss following organ transplantation, where DSA are directed towards patches on the three-dimensional ...
The importance of sustained compliance with physical distancing during COVID-19 vaccination rollout

Teslya, Alexandra; Rozhnova, Ganna; Pham, Thi Mui; van Wees, Daphne A; Nunner, Hendrik; Godijk, Noortje G; Bootsma, Martin; Kretzschmar, Mirjam E (Springer Nature, 2022-11-19)

BACKGROUND: Increasing vaccination coverage against SARS-CoV-2 enabled relaxation of lockdowns in many countries in Europe. As the vaccination rollouts progressed, the public health authorities were seeking recommendations ...
Dutch public health professionals' perspectives and needs regarding citizen involvement in COVID-19 contact tracing through digital support tools: an exploratory qualitative study

Helms, Y B; Stein, M L; Hamdiui, N; van der Meer, A; Baron, R; Eilers, R; Crutzen, R; Kretzschmar, M E E; Timen, A (BioMed Central, 2022-11-19)

BACKGROUND: Contact tracing (CT) is an important, but resource-intensive tool to control outbreaks of communicable diseases. Under pandemic circumstances, public health services may not have sufficient resources at their ...
Health behavior homophily can mitigate the spread of infectious diseases in small-world networks

Nunner, Hendrik; Buskens, Vincent; Teslya, Alexandra; Kretzschmar, Mirjam (Elsevier Limited, 2022-11)

Research has repeatedly shown that the spread of infectious diseases is influenced by properties of our social networks. Small-world like structures with densely connected clusters bridged by only a few connections, for ...
Selective Decontamination of the Digestive Tract: An Answer at Last?

Bonten, Marc (American Medical Association, 2022-12-20)
Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial

COMBACTE-MAGNET EVADE Study Group (Springer Science + Business Media, 2022-11-15)

Background: Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in ...
Exploring the "how" in research partnerships with young partners by experience: lessons learned in six projects from Canada, the Netherlands, and the United Kingdom

Nguyen, Linda; van Oort, Bente; Davis, Hanae; van der Meulen, Eline; Dawe-McCord, Claire; Franklin, Anita; Gorter, Jan Willem; Morris, Christopher; Ketelaar, Marjolijn (BioMed Central Ltd., 2022-11-17)

BACKGROUND: Involvement of young partners by experience in research is on the rise and becoming expected practice. However, literature on how to promote equitable and meaningful involvement of young people is scarce. The ...
Metrology in health: challenges and solutions in infusion therapy and diagnostics

Metaxiotou, Zoe; Batista, Elsa; Bissig, Hugo; do Céu Ferreira, Maria; Timmerman, AMDE (Walter de Gruyter GmbH & Co., 2023-02-01)

The significance of Metrology in infusion therapy and diagnostics, both critical in health care safety and quality, is discussed in this article. Although infusion therapy is the most used form of drug administration, ...
Lost in explanation: internal conflicts in the discourse of ADHD psychoeducation

van Langen, Myrte J.M.; Szőke, Rebeka; Rijkelijkhuizen, Dominique N.J.; Durston, Sarah; van Hulst, Branko M. (BioMed Central, 2022-11-08)

Background: Psychiatric classifications are understood in many different ways. For children with ADHD and their parents, psychoeducation is an important source of information for shaping their understanding. Moreover, ...
Psychiatrische symptomen en COVID-19: resultaten uit een landelijk register

van Dee, V.; Janssen, E. A.M.; Blom, R. M.; Cahn, W.; van Mierlo, H. C.; Mihaescu, R.; van Wullften Palthe, J.; Zijlstra, R.; Kok, R. M.; Everaerd, D. S.; Schellekens, A.; oviP-Consortium, C. (Uitgeverij Boom, 2022)

BACKGROUND: Psychiatric disorders are associated with a more severe course of COVID-19. COVID-19 can also lead to psychiatric symptoms. AIM: To gain insight into vulnerabilities and protective factors for the course of ...
Muva physical activity intervention to improve social functioning in people with a severe mental illness: study protocol of a pragmatic stepped wedge cluster randomized trial

Koomen, Lisanne Elisabeth Maria; van de Meent, Ilona Hendrika Theodora; Deenik, Jeroen; van Dellen, Edwin; Schnack, Hugo Gerard; van Werkhoven, Henri; Swildens, Wilma Elisabeth; van Meijel, Berno; Staal, Wouter; Jörg, Frederike; Scheepers, Floortje; Cahn, Wiepke (BioMed Central, 2022-12)

Background: People with severe mental illness (SMI) often suffer from long-lasting symptoms that negatively influence their social functioning, their ability to live a meaningful life, and participation in society. ...
Methenamine hippurate to prevent recurrent urinary tract infections in older women: protocol for a randomised, placebo-controlled trial (ImpresU)

Heltveit-Olsen, Silje Rebekka; Sundvall, Pär Daniel; Gunnarsson, Ronny; Snaebjörnsson Arnljots, Egill; Kowalczyk, Anna; Godycki-Cwirko, Maciek; Platteel, Tamara N.; Koning, Hilde A.M.; Groen, Wim G.; Åhrén, Christina; Grude, Nils; Verheij, Theo J.M.; Hertogh, Cees M.P.M.; Lindbaek, Morten; Hoye, Sigurd (BMJ Publishing Group, 2022-11-01)

INTRODUCTION: Methenamine hippurate is a urinary antiseptic used as preventive treatment for recurrent urinary tract infections (UTIs) in some Scandinavian countries. However, the scientific evidence for the preventive ...
A nationwide randomized controlled trial on additional treatment for isolated local pancreatic cancer recurrence using stereotactic body radiation therapy (ARCADE)

Dutch Pancreatic Cancer Group (BioMed Central, 2022-10-28)

BACKGROUND: Disease recurrence is the main cause of mortality after resection of pancreatic ductal adenocarcinoma (PDAC). In 20-30% of resected patients, isolated local PDAC recurrence occurs. Retrospective studies have ...
Dynamic Visualization of TGF-β/SMAD3 Transcriptional Responses in Single Living Cells

Marvin, Dieuwke L; You, Li; Bornes, Laura; van Dinther, Maarten; Peters, Niek; Dang, Hao; Hakuno, Sarah K; Hornsveld, Marten; Kranenburg, Onno; van Rheenen, Jacco; Rohling, Jos H T; Chien, Miao-Ping; Ten Dijke, Peter; Ritsma, Laila (Multidisciplinary Digital Publishing Institute (MDPI), 2022-05-19)

Transforming growth factor-β (TGF-β) signaling is tightly controlled in duration and intensity during embryonic development and in the adult to maintain tissue homeostasis. To visualize the TGF-β/SMAD3 signaling kinetics, ...
Cell-Free Circulating (Tumor) DNA before Surgery as a Prognostic Factor in Non-Metastatic Colorectal Cancer: A Systematic Review

Schraa, Suzanna J; van Rooijen, Karlijn L; Koopman, Miriam; Vink, Geraldine R; Fijneman, Remond J A (Multidisciplinary Digital Publishing Institute (MDPI), 2022-04-29)

Identification of non-metastatic colorectal cancer (CRC) patients with a high risk of recurrence after tumor resection is important to select patients who might benefit from adjuvant treatment. Cell-free DNA (cfDNA) and ...
Patient-Reported Symptoms of Late Toxicity in Patients With Breast Cancer Treated With Hypofractionated Radiation Therapy and the Association With Quality of Life

UMBRELLA study team (Elsevier, 2023-04-01)

PURPOSE: Our purpose was to assess the prevalence of patient-reported symptoms of local late toxicity in patients with irradiated breast cancer and determine the association between late toxicity and quality of life. ...

Now showing items 11541-11560 of 40729