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UMC Repository: Recent submissions

  • Predictive Parameters in Patients Undergoing Percutaneous Hepatic Perfusion with Melphalan for Unresectable Liver Metastases from Uveal Melanoma: A Retrospective Pooled Analysis 
    Tong, T M L; Samim, M; Kapiteijn, E; Meijer, T S; Speetjens, F M; Brüning, R; Schroeder, T H; El-Sanosy, S; Maschke, H; Wacker, F K; Vogel, A; Dewald, C L A; Goeman, J J; Burgmans, M C (Springer-Verlag, 2022-09)
    Purpose: The aim of this study was to identify positive predictors for survival in uveal melanoma (UM) patients treated with percutaneous hepatic perfusion with melphalan (M-PHP), by retrospectively pooling data from three ...
  • Computed tomographic bone mineral density is independently associated with adverse in-hospital outcomes in Dutch level-1 trauma patients 
    Kobes, Tim; Sweet, Arthur A R; Verstegen, Sophie B H; Houwert, R Marijn; Veldhuis, Wouter B; Leenen, Luke P H; de Jong, Pim A; van Baal, Mark C P M (Springer International Publishing AG, 2023-06)
    BACKGROUND: Aging, inactivity, and malnutrition are risk factors for adverse in-hospital outcomes and can manifest in bone loss. Use of bone mineral density (BMD) as an objective marker might improve early identification ...
  • Cardiovascular parameters on computed tomography are independently associated with in-hospital complications and outcomes in level-1 trauma patients 
    Kobes, Tim; Sweet, Arthur A R; Klip, IJsbrand T; Houwert, Roderick M; Veldhuis, Wouter B; Leenen, Luke P H; de Jong, Pim A; van Baal, Mark C P M (Springer International Publishing AG, 2023-06)
    BACKGROUND: In-hospital complications after trauma may result in prolonged stays, higher costs, and adverse functional outcomes. Among reported risk factors for complications are pre-existing cardiopulmonary comorbidities. ...
  • Optimized flip angle schemes for the split acquisition of fast spin-echo signals (SPLICE) sequence and application to diffusion-weighted imaging 
    Rahbek, Sofie; Schakel, Tim; Mahmood, Faisal; Madsen, Kristoffer H; Philippens, Marielle E P; Hanson, Lars G (John Wiley & Sons Inc., 2023-04)
    Purpose: The diffusion-weighted SPLICE (split acquisition of fast spin-echo signals) sequence employs split-echo rapid acquisition with relaxation enhancement (RARE) readout to provide images almost free of geometric ...
  • Longitudinal Follow-Up Using the Heel Enthesitis Magnetic Resonance Imaging Scoring System (HEMRIS) Shows Minimal Changes in Heel Enthesitis Assessed in Spondyloarthritis and Psoriasis Patients 
    Kleinrensink, Nienke J.; Foppen, Wouter; Katen, Iris ten; Leijten, Emmerik F.A.; de Jong, Pim A.; Spierings, Julia (MDPI Multidisciplinary Digital Publishing Institute, 2022-11)
    Enthesitis is a common clinical feature of spondyloarthritis (SpA). For reliable assessment of enthesitis the Heel Enthesitis Magnetic Resonance Imaging Scoring System (HEMRIS) was developed. The aims of this study were ...
  • Feasibility of quantitative sensory testing in juvenile idiopathic arthritis 
    Mensink, Maarten O; Eijkelkamp, Niels; Veldhuijzen, Dieuwke S; Wulffraat, Nico M (BioMed Central Ltd., 2022-08-09)
    OBJECTIVE: Juvenile Idiopathic Arthritis (JIA) is a childhood-rheumatic disease with pain as a major early complaint, and in 10-17% pain remains a major symptom. Very few data exist on sensory threshold changes at the knee ...
  • Sural Hypersensitivity after Nerve Transection depends on Anatomical Differences in the Distal Tibial Nerve of Mice and Rats 
    Brakkee, E M; DeVinney, E; Eijkelkamp, N; Coert, J H (Elsevier, 2023-02)
    INTRODUCTION: Various mouse and rat models of neuropathic pain after nerve injury exist. Whilst some models involve a proximal nerve lesion or ligation of the sciatic trifurcation in mice and rats, others consists of a ...
  • PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation 
    Madsen, Maria Stahl; Broekema, Marjoleine F.; Madsen, Martin Rønn; Koppen, Arjen; Borgman, Anouska; Gräwe, Cathrin; Thomsen, Elisabeth G.K.; Westland, Denise; Kranendonk, Mariette E.G.; Koerkamp, Marian Groot; Hamers, Nicole; Bonvin, Alexandre M.J.J.; Pittol, José M.Ramos; Natarajan, Kedar Nath; Kersten, Sander; Holstege, Frank C.P.; Monajemi, Houshang; van Mil, Saskia W.C.; Vermeulen, Michiel; Kragelund, Birthe B.; Cassiman, David; Mandrup, Susanne; Kalkhoven, Eric (Nature Publishing Group, 2022-12)
    Peroxisome proliferator-activated receptor γ (PPARγ) is the master regulator of adipocyte differentiation, and mutations that interfere with its function cause lipodystrophy. PPARγ is a highly modular protein, and structural ...
  • Endoscopic embolization of a refractory bronchobiliary fistula by endoscopic retrograde cholangiography using coils and Histoacryl 
    Didden, Paul; Bruijnen, Rutger C G; Vonken, Evert-Jan P A; Vleggaar, Frank P (Georg Thieme Verlag, 2023-12)
  • Predicting responders to prone positioning in mechanically ventilated patients with COVID-19 using machine learning 
    Dutch ICU Data Sharing Against Covid-19 Collaborators (Springer-Verlag GmbH and Co. KG, 2022-10-20)
    BACKGROUND: For mechanically ventilated critically ill COVID-19 patients, prone positioning has quickly become an important treatment strategy, however, prone positioning is labor intensive and comes with potential adverse ...
  • Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer's disease 
    Fernández Zapata, Camila; Giacomello, Ginevra; Spruth, Eike J; Middeldorp, Jinte; Gallaccio, Gerardina; Dehlinger, Adeline; Dames, Claudia; Leman, Julia K H; van Dijk, Roland E; Meisel, Andreas; Schlickeiser, Stephan; Kunkel, Desiree; Hol, Elly M; Paul, Friedemann; Parr, Maria Kristina; Priller, Josef; Böttcher, Chotima (Nature Publishing Group, 2022-11-23)
    Myeloid cells are suggested as an important player in Alzheimer´s disease (AD). However, its continuum of phenotypic and functional changes across different body compartments and their use as a biomarker in AD remains ...
  • Linked research hubs train students to tackle societal challenges 
    Schakelaar, Michael Y; Bassat, Quique; Comiskey, Catherine M; Felvinczi, Katalin; Haarhuis, Jan C M; Bovenschen, Niels (Nature Research, 2022-11-17)
    Letter to the Editor
  • Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort 
    Roemer, Frank W; Jansen, Mylène; Marijnissen, Anne C A; Guermazi, Ali; Heiss, Rafael; Maschek, Susanne; Lalande, Agnes; Blanco, Francisco J; Berenbaum, Francis; van de Stadt, Lotte A; Kloppenburg, Margreet; Haugen, Ida K; Ladel, Christoph H; Bacardit, Jaume; Wisser, Anna; Eckstein, Felix; Lafeber, Floris P J G; Weinans, Harrie H; Wirth, Wolfgang (BioMed Central, 2022-11-17)
    BACKGROUND: The IMI-APPROACH cohort is an exploratory, 5-centre, 2-year prospective follow-up study of knee osteoarthritis (OA). Aim was to describe baseline multi-tissue semiquantitative MRI evaluation of index knees and ...
  • Analysis of therapy monitoring in the International Congenital Adrenal Hyperplasia Registry 
    Lawrence, Neil; Bacila, Irina; Dawson, Jeremy; Bryce, Jillian; Ali, Salma R.; van den Akker, Erica L.T.; Bachega, Tânia A.S.S.; Baronio, Federico; Birkebæk, Niels H.; Bonfig, Walter; van der Grinten, Hedi C.; Costa, Eduardo C.; de Vries, Liat; Elsedfy, Heba; Güven, Ayla; Hannema, Sabine; Iotova, Violeta; van der Kamp, Hetty J.; Clemente, María; Lichiardopol, Corina R.; Milenkovic, Tatjana; Neumann, Uta; Nordenström, Ana; Poyrazoğlu, Şukran; Probst-Scheidegger, Ursina; De Sanctis, Luisa; Tadokoro-Cuccaro, Rieko; Thankamony, Ajay; Vieites, Ana; Yavaş, Zehra; Faisal Ahmed, Syed; Krone, Nils (Wiley-Blackwell, 2022-11)
    OBJECTIVE: Congenital adrenal hyperplasia (CAH) requires exogenous steroid replacement. Treatment is commonly monitored by measuring 17-OH progesterone (17OHP) and androstenedione (D4). DESIGN: Retrospective cohort study ...
  • Case report: Refractory cardiac arrest supported with veno-arterial-venous extracorporeal membrane oxygenation and left-ventricular Impella CP®–Physiological insights and pitfalls of ECMELLA 
    Thevathasan, Tharusan; Füreder, Lisa; Donker, Dirk W.; Nix, Christoph; Wurster, Thomas H.; Knie, Wulf; Girke, Georg; Al Harbi, Abdulla S.; Landmesser, Ulf; Skurk, Carsten (Frontiers Media S. A., 2022-11-04)
    Introduction: To the best of our knowledge, this is the first case report which provides insights into patient-specific hemodynamics during veno-arterio-venous-extracorporeal membrane oxygenation (VAV ECMO) combined with ...
  • Future steps in cardio-oncology: a national multidisciplinary survey among healthcare professionals in the Netherlands 
    Koop, Yvonne; Teske, Arco J.; Wanders, Iris; Meijer, Hanneke; Kaanders, J. H.A.M.(Hans); Manintveld, Olivier C.; Hassing, H. Carlijne; Vermeulen, Hester; Maas, Angela H.E.M.; van Spronsen, Dick Johan; Atsma, Femke; El Messaoudi, Saloua (Springer, 2023-08)
    Background: The awareness of cancer therapy–related adverse cardiac effects is fueled by recent literature on cardiotoxicity incidence and detection strategies. Although this influences the sense of urgency, in current ...
  • Quality of life in breast cancer patients with cancer treatment-related cardiac dysfunction: a qualitative study 
    Koop, Yvonne; Van Zadelhof, Nikita; Maas, Angela H.E.M.; Atsma, Femke; El Messaoudi, Saloua; Vermeulen, Hester (Elsevier, 2022-04-09)
    Background: Although improved breast cancer (BC) treatment has decreased mortality, these anti-cancer regimens may have serious cardiovascular side effects that affect patients' long-term prognosis and quality of life ...
  • Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient 
    Wheatley, Rachel M.; Caballero, Julio Diaz; van der Schalk, Thomas E.; De Winter, Fien H.R.; Shaw, Liam P.; Kapel, Natalia; Recanatini, Claudia; Timbermont, Leen; Kluytmans, Jan; Esser, Mark; Lacoma, Alicia; Prat-Aymerich, Cristina; Oliver, Antonio; Kumar-Singh, Samir; Malhotra-Kumar, Surbhi; Craig MacLean, R. (Nature Publishing Group, 2022-11-22)
    Bacteria have the potential to translocate between sites in the human body, but the dynamics and consequences of within-host bacterial migration remain poorly understood. Here we investigate the link between gut and lung ...
  • Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry 
    De Luca, Giuseppe; Algowhary, Magdy; Uguz, Berat; Oliveira, Dinaldo C; Ganyukov, Vladimir; Zimbakov, Zan; Cercek, Miha; Jensen, Lisette Okkels; Loh, Poay Huan; Calmac, Lucian; Ferrer, Gerard Roura I; Quadros, Alexandre; Milewski, Marek; Scotto D'Uccio, Fortunato; von Birgelen, Clemens; Versaci, Francesco; Ten Berg, Jurrien; Casella, Gianni; Wong Sung Lung, Aaron; Kala, Petr; Díez Gil, José Luis; Carrillo, Xavier; Dirksen, Maurits; Becerra-Munoz, Victor M; Lee, Michael Kang-Yin; Juzar, Dafsah Arifa; Joaquim, Rodrigo de Moura; Paladino, Roberto; Milicic, Davor; Davlouros, Periklis; Bakraceski, Nikola; Zilio, Filippo; Donazzan, Luca; Kraaijeveld, Adriaan; Galasso, Gennaro; Arpad, Lux; Lucia, Marinucci; Vincenzo, Guiducci; Menichelli, Maurizio; Scoccia, Alessandra; Yamac, Aylin Hatice; Ugur Mert, Kadir; Flores Rios, Xacobe; Kovarnik, Tomas; Kidawa, Michal; Moreu, Josè; Vincent, Flavien; Fabris, Enrico; Martínez-Luengas, Iñigo Lozano; Boccalatte, Marco; Bosa Ojeda, Francisco; Arellano-Serrano, Carlos; Caiazzo, Gianluca; Cirrincione, Giuseppe; Kao, Hsien-Li; Sanchis Forés, Juan; Vignali, Luigi; Pereira, Helder; Manzo, Stephane; Ordoñez, Santiago; Özkan, Alev Arat; Scheller, Bruno; Lehtola, Heidi; Teles, Rui; Mantis, Christos; Antti, Ylitalo; Silveira, João António Brum; Zoni, Rodrigo; Bessonov, Ivan; Savonitto, Stefano; Kochiadakis, George; Alexopulos, Dimitrios; Uribe, Carlos E; Kanakakis, John; Faurie, Benjamin; Gabrielli, Gabriele; Barrios, Alejandro Gutierrez; Bachini, Juan Pablo; Rocha, Alex; Tam, Frankie Chor-Cheung; Rodriguez, Alfredo; Lukito, Antonia Anna; Saint-Joy, Veauthyelau; Pessah, Gustavo; Tuccillo, Andrea; Cortese, Giuliana; Parodi, Guido; Bouraghda, Mohamed Abed; Kedhi, Elvin; Lamelas, Pablo; Suryapranata, Harry; Nardin, Matteo; Verdoia, Monica (Multidisciplinary Digital Publishing Institute (MDPI), 2022-11-13)
    The so-called “smoking paradox”, conditioning lower mortality in smokers among STEMI patients, has seldom been addressed in the settings of modern primary PCI protocols. The ISACS–STEMI COVID-19 is a large-scale retrospective ...
  • Association between sports participation, factor VIII levels and bleeding in hemophilia A 
    Bukkems, Laura; Versloot, Olav; Cnossen, M; Jonsson, Siv; Karlsson, Mats; Mathôt, Ron A; Fischer, Kathelijn (Schattauer GmbH, 2023-03-02)
    Background Little is known on how sports participation affects bleeding risk in hemophilia. This study aimed to examine associations between sports participation, factor VIII (FVIII) levels and bleeding in persons with ...