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Now showing items 11241-11260 of 40729

IKs inhibitor JNJ303 prolongs the QT interval and perpetuates arrhythmia when combined with enhanced inotropy in the CAVB dog

van Bavel, Joanne J.A.; Beekman, Henriëtte D.M.; van Weperen, Valerie Y.H.; van der Linde, Henk J.; van der Heyden, Marcel A.G.; Vos, Marc A. (Elsevier, 2022-10-15)

Introduction: Impaired IKs induced by drugs or due to a KCNQ1 mutation, diagnosed as long QT syndrome type 1 (LQT1) prolongs the QT interval and predisposes the heart to Torsade de Pointes (TdP) arrhythmias. The anesthetized ...
Safety of Thioguanine in Pediatric Inflammatory Bowel Disease: A Multi-Center Case Series

Bayoumy, Ahmed B.; Jagt, Jasmijn Z.; Van Wering, Herbert M.; De Ridder, Lissy; Hummel, Thalia; Wolters, Victorien M.; Stapelbroek, Janneke; Benninga, Marc A.; Mulder, Chris J.J.; De Boer, Nanne K.H.; De Meij, Tim G.J. (Lippincott Williams & Wilkins, 2022-12-01)

Objectives: Thioguanine (TG) has been shown as a safe alternative in adults with inflammatory bowel disease (IBD) who did not tolerate conventional thiopurines [azathioprine (AZA)/mercaptopurine]. However, data in pediatric ...
Individualised prediction of drug resistance and seizure recurrence after medication withdrawal in people with juvenile myoclonic epilepsy: A systematic review and individual participant data meta-analysis

EpiPGX Consortium (Elsevier, 2022-11)

Background: A third of people with juvenile myoclonic epilepsy (JME) are drug-resistant. Three-quarters have a seizure relapse when attempting to withdraw anti-seizure medication (ASM) after achieving seizure-freedom. It ...
The severity of chronic histiocytic intervillositis is associated with gestational age and fetal weight

Bos, M.; Koenders, M. J.M.; Dijkstra, K. L.; van der Meeren, L. E.; Nikkels, P. G.J.; Bloemenkamp, K. W.M.; Eikmans, M.; Baelde, H. J.; van der Hoorn, M. L.P. (W.B. Saunders Ltd, 2023-01)

Introduction: Chronic histiocytic intervillositis (CHI) is a rare histopathological lesion in the placenta that is associated with poor reproductive outcomes. The intervillous infiltrate consists mostly of maternal mononuclear ...
Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma

Rohaan, Maartje W; Borch, Troels H; van den Berg, Joost H; Met, Özcan; Kessels, Rob; Geukes Foppen, Marnix H; Stoltenborg Granhøj, Joachim; Nuijen, Bastiaan; Nijenhuis, Cynthia; Jedema, Inge; van Zon, Maaike; Scheij, Saskia; Beijnen, Jos H; Hansen, Marten; Voermans, Carlijn; Noringriis, Inge M; Monberg, Tine J; Holmstroem, Rikke B; Wever, Lidwina D V; van Dijk, Marloes; Grijpink-Ongering, Lindsay G; Valkenet, Ludy H M; Torres Acosta, Alejandro; Karger, Matthias; Borgers, Jessica S W; Ten Ham, Renske M T; Retèl, Valesca P; van Harten, Wim H; Lalezari, Ferry; van Tinteren, Harm; van der Veldt, Astrid A M; Hospers, Geke A P; Stevense-den Boer, Marion A M; Suijkerbuijk, Karijn P M; Aarts, Maureen J B; Piersma, Djura; van den Eertwegh, Alfons J M; de Groot, Jan-Willem B; Vreugdenhil, Gerard; Kapiteijn, Ellen; Boers-Sonderen, Marye J; Fiets, W Edward; van den Berkmortel, Franchette W P J; Ellebaek, Eva; Hölmich, Lisbet R; van Akkooi, Alexander C J; van Houdt, Winan J; Wouters, Michel W J M; van Thienen, Johannes V; Blank, Christian U; Meerveld-Eggink, Aafke; Klobuch, Sebastian; Wilgenhof, Sofie; Schumacher, Ton N; Donia, Marco; Svane, Inge Marie; Haanen, John B A G (Massachussetts Medical Society, 2022-12-08)

Background Immune checkpoint inhibitors and targeted therapies have dramatically improved outcomes in patients with advanced melanoma, but approximately half these patients will not have a durable benefit. Phase 1-2 trials ...
Long-term cardiovascular health status and physical functioning of nonhospitalized patients with COVID-19 compared with non-COVID-19 controls

van der Sluijs, Koen M; Bakker, Esmée A; Schuijt, Tim; Joseph, Jayaraj; Kavousi, Maryam; Geersing, Geert-Jan; Rutten, Frans H; Hartman, Yvonne A W; Thijssen, Dick H J; Eijsvogels, Thijs M H (American Physiological Society, 2023-01)

Coronavirus disease 2019 (COVID-19) is reported to have long-term effects on cardiovascular health and physical functioning, even in the nonhospitalized population. The physiological mechanisms underlying these long-term ...
Visceral adipose tissue quantity and dysfunction and the occurrence of major bleeding in patients with established cardiovascular disease

Castelijns, Maria C.; Hageman, Steven H.J.; Ruigrok, Ynte M.; van der Meer, Manon G.; Teraa, Martin; Westerink, Jan; Visseren, Frank L.J. (Elsevier, 2023-01-01)

Objectives: To determine the association between both visceral fat quantity and adipose tissue dysfunction, and major bleeding in patients with established cardiovascular disease. Methods: Patients from the Second ...
Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries

PRECISE4Q Consortium; FinnGen Consortium; NINDS Stroke Genetics Network (SiGN); MEGASTROKE Consortium; SIREN Consortium; China Kadoorie Biobank Collaborative Group; VA Million Veteran Program; International Stroke Genetics Consortium (ISGC); Biobank Japan; CHARGE Consortium; GIGASTROKE Consortium; COMPASS Consortium; INVENT Consortium; Dutch Parelsnoer Initiative (PSI) Cerebrovascular Disease Study Group; Estonian Biobank (Nature Research, 2022-11-14)
Opinions on hypertension care and therapy adherence at the healthcare provider and healthcare system level: a qualitative study in the Hague, Netherlands

Van Grondelle, Saskia E.; Van Bruggen, Sytske; Meijer, Judith; Van Duin, Erik; Bots, Michiel L.; Rutten, Guy; Vos, Hedwig M.M.; Numans, Mattijs E.; Vos, Rimke C. (BMJ Publishing Group, 2022-07-08)

Objectives Hypertension is a common cause of cardiovascular morbidity and mortality. Although hypertension can be effectively controlled by blood pressure-lowering drugs, uncontrolled blood pressure is common despite use ...
Clinical characteristics do not reliably identify non-adherence in patients with uncontrolled hypertension

Groenland, Eline H.; Dasgupta, Indranil; Visseren, Frank L.J.; van der Elst, Kim C.M.; Lorde, Nathan; Lawson, Alexander J.; Bots, Michiel L.; Spiering, Wilko (Informa Healthcare, 2022-07-27)

Purpose: Chemical adherence testing is a reliable method to assess adherence to antihypertensive drugs. However, it is expensive and has limited availability in clinical practice. To reduce the number and costs of chemical ...
Smartphone Application-Assisted Home Blood Pressure Monitoring Compared With Office and Ambulatory Blood Pressure Monitoring in Patients With Hypertension: the AMUSE-BP Study

Groenland, Eline H.; Vendeville, Jean Paul A.C.; Bemelmans, Remy H.H.; Monajemi, Houshang; Bots, Michiel L.; Visseren, Frank L.J.; Spiering, Wilko (Lippincott Williams & Wilkins, 2022-10-01)

BACKGROUND: The development of automated, smartphone application (app)-assisted home blood pressure monitoring (HBPM) allows for standardized measurement of blood pressure (BP) at home. The aim of this study was to evaluate ...
Rosuvastatin Slows Progression of Carotid Intima-Media Thickness: The METEOR-China Randomized Controlled Study

Zheng, Huaguang; Li, Hongwei; Wang, Yilong; Li, Zhanquan; Hu, Bo; Li, Xiaogang; Fu, Lu; Hu, Hongtao; Nie, Zhiyu; Zhao, Bilian; Wei, Di; Karlson, Björn W.; Bots, Michiel L.; Meng, Xiang Wen; Chen, Yundai; Wang, Yongjun (Lippincott Williams & Wilkins, 2022-10)

Background: Atherosclerosis is the leading cause of cardiovascular disease worldwide, including in China. Primary prevention, through lipid-lowering, could avert development of atherosclerosis. Carotid intima-media thickness ...
Carotid tortuosity is associated with extracranial carotid artery aneurysms

van Laarhoven, Constance J.H.C.M.; Willemsen, Saskia I.; Klaassen, Jurre; de Vries, Evelien E.; van der Vliet, Quirine M.J.; Hazenberg, Constantijn E.V.B.; Bots, Michiel L.; de Borst, Gert J. (AME Publishing Company, 2022-11)

BACKGROUND: Tortuous arteries may be associated with carotid dissection. The intima disruption caused by a carotid dissection is a possible cause of extracranial carotid artery aneurysms (ECAAs). The aim was to investigate ...
Evidence for pharmacological interventions to reduce cardiovascular risk for patients with chronic kidney disease: a study protocol of an evidence map

Colombijn, Julia M.T.; Idema, Demy L.; van der Braak, Kim; Spijker, Rene; Meijvis, Sabine C.A.; Bots, Michiel L.; Hooft, Lotty; Verhaar, Marianne C.; Vernooij, Robin W.M. (BioMed Central, 2022-11-12)

Background: Patients with chronic kidney disease (CKD) require a personalised strategy for cardiovascular risk management (CVRM) to reduce their high risk of cardiovascular morbidity and mortality. Despite their high risk, ...
Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement

Salomon, Carlos; Das, Saumya; Erdbrügger, Uta; Kalluri, Raghu; Kiang Lim, Sai; Olefsky, Jerrold M.; Rice, Gregory E.; Sahoo, Susmita; Andy Tao, W.; Vader, Pieter; Wang, Qun; Weaver, Alissa M. (The Endocrine Society, 2022-06)

During the last decade, there has been great interest in elucidating the biological role of extracellular vesicles (EVs), particularly, their hormone-like role in cell-to-cell communication. The field of endocrinology is ...
Challenges and directions in studying cell–cell communication by extracellular vesicles

van Niel, Guillaume; Carter, David R.F.; Clayton, Aled; Lambert, Daniel W.; Raposo, Graça; Vader, Pieter (Nature Research, 2022-05)

Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. They have important roles in numerous physiological and pathological processes, and show considerable promise ...
Extracellular Vesicle-Based Hybrid Systems for Advanced Drug Delivery

Rodríguez, Diego A.; Vader, Pieter (Multidisciplinary Digital Publishing Institute, 2022-02)

The continuous technological advancement of nanomedicine has enabled the development of novel vehicles for the effective delivery of therapeutic substances. Synthetic drug delivery systems are nano-sized carriers made from ...
Isolation methods of large and small extracellular vesicles derived from cardiovascular progenitors: A comparative study

Saludas, Laura; Garbayo, Elisa; Ruiz-Villalba, Adrián; Hernández, Silvia; Vader, Pieter; Prósper, Felipe; Blanco-Prieto, María J. (Elsevier, 2022-01)

Since the discovery of the beneficial therapeutical effects of extracellular vesicles (EVs), these agents have been attracting great interest as next-generation therapies. EVs are nanosized membrane bodies secreted by all ...
Dupilumab has a profound effect on specific-IgE levels of several food allergens in atopic dermatitis patients

Spekhorst, Lotte S; van der Rijst, Lisa P; de Graaf, Marlies; van Megen, Maxime; Zuithoff, Nicolaas P A; Knulst, André C; de Bruin-Weller, Marjolein S; Le, Thuy-My (Wiley-Blackwell, 2023-03)
Daily Practice Experience of Baricitinib Treatment for Patients with Difficult-to-Treat Atopic Dermatitis: Results from the BioDay Registry

Boesjes, Celeste M.; Kamphuis, Esmé; Zuithoff, Nicolaas P.A.; Bakker, Daphne S.; Loman, Laura; Spekhorst, Lotte S.; Haeck, Inge; Kamsteeg, Marijke; VAN LYNDEN-VAN NES, Anneke M.T.; Garritsen, Floor M.; Politiek, Klaziena; Oldhoff, Marja; DE GRAAF, Marlies; Schuttelaar, Marie L.A.; DE BRUIN-WELLER, Marjolein S. (Medical Journals Sweden AB, 2022-11-24)

Clinical trials have shown that baricitinib, an oral selective Janus kinase 1/2 inhibitor, is effective for the treatment of moderate-to-severe atopic dermatitis. However, daily practice data are limited. Therefore, this ...

Now showing items 11241-11260 of 40729