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UMC Repository: Recent submissions

  • Prospective Study of Drug-induced Interstitial Lung Disease in Advanced Breast Cancer Patients Receiving Everolimus Plus Exemestane 
    Willemsen, Annelieke E.C.A.B.; Tol, Jolien; van Erp, Nielka P.; Jonker, Marianne A.; de Boer, Maaike; Meek, Bob; de Jong, Paul C.; van Moorsel, Coline; Gerritsen, Winald R.; Grutters, Jan C.; van Herpen, Carla M.L. (Springer Paris, 2019-08-01)
    Background: Everolimus-related interstitial lung disease (ILD) (also: pneumonitis) poses a difficulty for physicians, as it is hard to discriminate ILD from other causes of respiratory symptoms and to decide on safe treatment ...
  • Nosology of genetic skeletal disorders: 2023 revision 
    Unger, Sheila; Ferreira, Carlos R; Mortier, Geert R; Ali, Houda; Bertola, Débora R; Calder, Alistair; Cohn, Daniel H; Cormier-Daire, Valerie; Girisha, Katta M; Hall, Christine; Krakow, Deborah; Makitie, Outi; Mundlos, Stefan; Nishimura, Gen; Robertson, Stephen P; Savarirayan, Ravi; Sillence, David; Simon, Marleen; Sutton, V Reid; Warman, Matthew L; Superti-Furga, Andrea (John Wiley & Sons Inc., 2023-05)
    The "Nosology of genetic skeletal disorders" has undergone its 11th revision and now contains 771 entries associated with 552 genes reflecting advances in molecular delineation of new disorders thanks to advances in DNA ...
  • Intraoperative Imaging Techniques to Improve Surgical Resection Margins of Oropharyngeal Squamous Cell Cancer: A Comprehensive Review of Current Literature † 
    de Kleijn, Bertram J.; Heldens, Gijs T.N.; Herruer, Jasmijn M.; Sier, Cornelis F.M.; Piazza, Cesare; de Bree, Remco; Guntinas-Lichius, Orlando; Kowalski, Luiz P.; Vander Poorten, Vincent; Rodrigo, Juan P.; Zidar, Nina; Nathan, Cherie Ann; Tsang, Raymond K.; Golusinski, Pawel; Shaha, Ashok R.; Ferlito, Alfio; Takes, Robert P. (Multidisciplinary Digital Publishing Institute (MDPI), 2023-02)
    Inadequate resection margins in head and neck squamous cell carcinoma surgery necessitate adjuvant therapies such as re-resection and radiotherapy with or without chemotherapy and imply increasing morbidity and worse ...
  • Neutrophil to Lymphocyte Ratio in Oropharyngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis † 
    Rodrigo, Juan P.; Sánchez-Canteli, Mario; Triantafyllou, Asterios; de Bree, Remco; Mäkitie, Antti A.; Franchi, Alessandro; Hellquist, Henrik; Saba, Nabil F.; Stenman, Göran; Takes, Robert P.; Valero, Cristina; Zidar, Nina; Ferlito, Alfio (Multidisciplinary Digital Publishing Institute (MDPI), 2023-02-01)
    Neutrophil-to-lymphocyte ratio (NLR) has been associated with survival in various cancers, including head and neck cancer. However, there is limited information on its role in oropharyngeal squamous cell carcinomas (OPSCC) ...
  • Aggressive versus indolent insulinomas - new clinicopathological insights 
    Hackeng, Wenzel M; Brosens, Lodewijk A A; Dreijerink, Koen M A (BioScientifica Ltd., 2023-05-01)
    Insulinomas are rare functional pancreatic neuroendocrine tumors. While most insulinomas are indolent and cured after surgery, 10-15% of cases show aggressive or malignant tumor behavior and metastasize locally or to distant ...
  • Biomarkers in atopic dermatitis 
    Bakker, Daphne; de Bruin-Weller, Marjolein; Drylewicz, Julia; van Wijk, Femke; Thijs, Judith (Mosby Inc., 2023-05)
    Atopic dermatitis (AD) is a complex and highly heterogeneous inflammatory skin disease. Given the highly heterogeneous character of AD, it is unlikely that every patient will respond equally to a particular treatment. The ...
  • Cartesian vs radial MR-STAT: An efficiency and robustness study 
    van der Heide, Oscar; Sbrizzi, Alessandro; van den Berg, Cornelis A.T. (Elsevier, 2023-06)
    MR Spin TomogrAphy in Time-domain (“MR-STAT”) is quantitative MR technique in which multiple quantitative parameters are estimated from a single short scan by solving a large-scale non-linear optimization problem. In this ...
  • Internet-delivered cognitive behavioural therapy for chronic fatigue among adolescents with a chronic medical condition: a single case study 
    Nijhof, Linde N; Nijhof, Sanne L; van de Putte, Elise M; Houtveen, Jan; van Montfrans, Joris M; Knoop, Hans (Cambridge University Press, 2023-05-15)
    BACKGROUND: Severe fatigue is a prominent symptom among adolescents with a chronic medical condition, with major impact on their well-being and daily functioning. Internet-based cognitive behavioural therapy (I-CBT) is a ...
  • Initial symptoms and three months follow-up after acute COVID-19 in outpatients: An international prospective cohort study 
    Hedin, Katarina; van der Velden, Alike W.; Hansen, Malene Plejdrup; Moberg, Anna B.; Balan, Anca; Bruno, Pascale; Coenen, Samuel; Johansen, Eskild; Kowalczyk, Anna; Kurotschka, Peter Konstantin; van der Linde, Sanne R.; Malania, Lile; Rohde, Jörn; Verbakel, Jan; Vornhagen, Heike; Vellinga, Akke (Informa Healthcare, 2023-12)
    Background: Most studies on long-term follow-up of patients with COVID-19 focused on hospitalised patients. No prospective study with structured follow-up has been performed in non-hospitalised patients with COVID-19. ...
  • Inpatient physical activity across a large university city hospital: a behavioral mapping study 
    Valkenet, Karin; McRae, Prue; Reijneveld, Elja; Jans, Marielle; Bor, Petra; van Delft, Lotte; Young, Daniel L; Veenhof, Cindy (Informa Healthcare, 2024-01-02)
    BACKGROUND: Physical inactivity is common during hospitalization. Physical activity has been described in different inpatient populations but never across a hospital. PURPOSE: To describe inpatient movement behavior and ...
  • Physical activity monitoring during hospital stay: a validation study 
    Valkenet, Karin; Bor, Petra; Reijneveld, Elja; Veenhof, Cindy; Dronkers, Jaap (Informa Healthcare, 2023-02)
    PURPOSE: The primary aim of this study was to investigate the concurrent validity of the PAM AM400 accelerometer for measuring physical activity in usual care in hospitalized patients by comparing it with the ActiGraph ...
  • Long-term efficacy and safety of inclisiran in patients with high cardiovascular risk and elevated LDL cholesterol (ORION-3): results from the 4-year open-label extension of the ORION-1 trial 
    Ray, Kausik K.; Troquay, Roel P.T.; Visseren, Frank L.J.; Leiter, Lawrence A.; Scott Wright, R.; Vikarunnessa, Sheikh; Talloczy, Zsolt; Zang, Xiao; Maheux, Pierre; Lesogor, Anastasia; Landmesser, Ulf (Elsevier, 2023-02)
    Introduction: Whether long-term treatment with the twice-yearly, siRNA therapeutic inclisiran, which reduces hepatic production of proprotein convertase subtilisin/kexin type 9 (PCSK9), results in sustained reductions in ...
  • Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas 
    Verma, Nirmal; Velmurugan, Gopal Viswanathan; Winford, Edric; Coburn, Han; Kotiya, Deepak; Leibold, Noah; Radulescu, Laura; Despa, Sanda; Chen, Kuey C.; Van Eldik, Linda J.; Nelson, Peter T.; Wilcock, Donna M.; Jicha, Gregory A.; Stowe, Ann M.; Goldstein, Larry B.; Powel, David K.; Walton, Jeffrey H.; Navedo, Manuel F.; Nystoriak, Matthew A.; Murray, Andrew J.; Biessels, Geert Jan; Troakes, Claire; Zetterberg, Henrik; Hardy, John; Lashley, Tammaryn; Despa, Florin (Springer Nature, 2023-01-03)
    Impairment of vascular pathways of cerebral β-amyloid (Aβ) elimination contributes to Alzheimer disease (AD). Vascular damage is commonly associated with diabetes. Here we show in human tissues and AD-model rats that ...
  • Abnormalities in cardiac-induced brain tissue deformations are now detectable with MRI: A case-report of a patient who underwent craniotomy after trauma 
    Sloots, Jacob Jan; Biessels, Geert Jan; Amelink, G. Johan; Zwanenburg, Jaco J.M. (Elsevier, 2023-05)
    Background: Heartbeat and respiration induce cyclic brain tissue deformations, which receive increasing attention as potential driving force for brain clearance. These deformations can now be assessed using a novel 3D ...
  • Disentangling poststroke cognitive deficits and their neuroanatomical correlates through combined multivariable and multioutcome lesion-symptom mapping 
    Weaver, Nick A.; Mamdani, Muhammad Hasnain; Lim, Jae Sung; Biesbroek, Johannes Matthijs; Biessels, Geert Jan; Huenges Wajer, Irene M.C.; Kang, Yeonwook; Kim, Beom Joon; Lee, Byung Chul; Lee, Keon Joo; Yu, Kyung Ho; Bae, Hee Joon; Bzdok, Danilo; Kuijf, Hugo J. (Wiley-Liss Inc., 2023-04-15)
    Studies in patients with brain lesions play a fundamental role in unraveling the brain's functional anatomy. Lesion-symptom mapping (LSM) techniques can relate lesion location to cognitive performance. However, a limitation ...
  • Burden, anxiety and depressive symptoms in partners - course and predictors during the first two years after stroke 
    Cox, Vincent C M; Welten, Jennifer J E; Schepers, Vera P M; Ketelaar, Marjolijn; Kruithof, Willeke J; van Heugten, Caroline M; Visser-Meily, Johanna M A (Taylor and Francis Ltd., 2023-09)
    BACKGROUND: Partners of patients with stroke are at high risk for burden, anxiety and depressive symptoms. Previous studies have reported contradictory results and did not investigate these three courses simultaneously. ...
  • Soluble Signal Inhibitory Receptor on Leukocytes-1 Is Released from Activated Neutrophils by Proteinase 3 Cleavage 
    von Richthofen, Helen J.; Westerlaken, Geertje H.A.; Gollnast, Doron; Besteman, Sjanna; Delemarre, Eveline M.; Rodenburg, Karlijn; Moerer, Petra; Stapels, Daphne A.C.; Andiappan, Anand K.; Rötzschke, Olaf; Nierkens, Stefan; Leavis, Helen L.; Bont, Louis J.; Rooijakkers, Suzan H.M.; Meyaard, Linde (American Association of Immunologists, 2023-02-15)
    Signal inhibitory receptor on leukocytes-1 (SIRL-1) is an immune inhibitory receptor expressed on human granulocytes and monocytes that dampens antimicrobial functions. We previously showed that sputum neutrophils from ...
  • Cell-Free DNA as a Diagnostic and Prognostic Biomarker in Pediatric Rhabdomyosarcoma 
    Lak, Nathalie S M; van Zogchel, Lieke M J; Zappeij-Kannegieter, Lily; Javadi, Ahmad; van Paemel, Ruben; Vandeputte, Charlotte; De Preter, Katleen; De Wilde, Bram; Chicard, Mathieu; Iddir, Yasmine; Schleiermacher, Gudrun; Ruhen, Olivia; Shipley, Janet; Fiocco, Marta; Merks, Johannes H M; van Noesel, Max M; van der Schoot, C Ellen; Tytgat, Godelieve A M; Stutterheim, Janine (Lippincott Williams & Wilkins, 2023-01)
    PURPOSE Total cell-free DNA (cfDNA) and tumor-derived cfDNA (ctDNA) can be used to study tumor-derived genetic aberrations. We analyzed the diagnostic and prognostic potential of cfDNA and ctDNA, obtained from pediatric ...
  • Adjuvant BRAF-MEK Inhibitors versus Anti PD-1 Therapy in Stage III Melanoma: A Propensity-Matched Outcome Analysis 
    De Meza, Melissa M.; Blokx, Willeke A.M.; Bonenkamp, Johannes J.; Blank, Christian U.; Aarts, Maureen J.B.; van den Berkmortel, Franchette W.P.J.; Boers-Sonderen, Marye J.; De Groot, Jan Willem B.; Haanen, John B.A.G.; Hospers, Geke A.P.; Kapiteijn, Ellen; Van Not, Olivier J.; Piersma, Djura; Van Rijn, Rozemarijn S.; Stevense-den Boer, Marion; Van der Veldt, Astrid A.M.; Vreugdenhil, Gerard; Van den Eertwegh, Alfonsus J.M.; Suijkerbuijk, Karijn P.M.; Wouters, Michel W.J.M. (Multidisciplinary Digital Publishing Institute (MDPI), 2023-01)
    Adjuvant BRAF/MEK- and anti-PD-1 inhibition have significantly improved recurrence-free survival (RFS) compared to placebo in resected stage III BRAF-mutant melanoma. However, data beyond the clinical trial setting are ...
  • Population mortality in advanced melanoma patients with and without response and progression; data from the Dutch Melanoma Treatment Registry 
    van Breeschoten, Jesper; van den Eertwegh, Alfons J.M.; Hilarius, Doranne L.; Haanen, John B.; Blank, Christian U.; Aarts, Maureen J.B.; van den Berkmortel, Franchette W.P.J.; de Groot, Jan Willem B.; Hospers, Geke A.P.; Kapiteijn, Ellen; Piersma, Djura; van Rijn, Rozemarijn S.; Stevense-den Boer, Marion A.; van der Veldt, Astrid A.M.; Vreugdenhil, Gerard; Boers-Sonderen, Marye J.; Manevski, Damjan; Suijkerbuijk, Karijn P.M.; Wouters, Michel W.J.M.; de Wreede, Liesbeth C. (Elsevier Limited, 2023-03)
    INTRODUCTION: When analysing patient survival, one is often interested in cause of death. Little is known about the presence of population mortality in advanced melanoma patients. The aim of this study was to assess ...