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UMC Repository: Recent submissions

  • Acute effects of cochleostomy and electrode-array insertion on compound action potentials in normal-hearing guinea pigs 
    Jwair, Saad; Ramekers, Dyan; Thomeer, Hans G.X.M.; Versnel, Huib (Frontiers Media S. A., 2023-02-08)
    Introduction: Electrocochleography (ECochG) is increasingly used in cochlear implant (CI) surgery, in order to monitor the effect of insertion of the electrode array aiming to preserve residual hearing. However, obtained ...
  • Deep Learning-Based Segmentation of Locally Advanced Breast Cancer on MRI in Relation to Residual Cancer Burden: A Multiinstitutional Cohort Study 
    Janse, Markus H.A.; Janssen, Liselore M.; van der Velden, Bas H.M.; Moman, Maaike R.; Wolters-van der Ben, Elian J.M.; Kock, Marc C.J.M.; Viergever, Max A.; van Diest, Paul J.; Gilhuijs, Kenneth G.A. (John Wiley & Sons Inc., 2023-12)
    Background: While several methods have been proposed for automated assessment of breast-cancer response to neoadjuvant chemotherapy on breast MRI, limited information is available about their performance across multiple ...
  • Omega-3 fatty acids in heart disease-why accurately measured levels matter 
    von Schacky, C; Kuipers, R S; Pijl, H; Muskiet, F A J; Grobbee, D E (Bohn Stafleu van Loghum, 2023-11)
    Current guidelines barely support marine omega‑3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in cardiology, mainly because results of large trials were equivocal. Most large trials have tested ...
  • Optimizing cardiovascular risk assessment and registration in a developing cardiovascular learning health care system: Women benefit most 
    Groenhof, T. J.Katrien; Haitjema, Saskia; Lely, A. T.; Grobbee, Diederick E.; Asselbergs, F. W.; Bots, Michiel L.; van Solinge, Wouter; Hoefer, I. E.; Haitjema, Saskia; de Groot, Mark; Asselbergs, F. W.; de Borst, G. J.; Bots, Michiel L.; Dieleman, S.; Emmelot, M. H.; de Jong, P. A.; Lely, A. T.; Hoefer, I. E.; van der Kaaij, N. P.; Ruigrok, Y. M.; Verhaar, M. C.; Visseren, F. L.J.; the UCC-CVRM; UPOD Study groups (Public Library of Science, 2023-02-01)
    Since 2015 we organized a uniform, structured collection of a fixed set of cardiovascular risk factors according the (inter)national guidelines on cardiovascular risk management. We evaluated the current state of a developing ...
  • Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients 
    CLEAR Outcomes Investigators (Massachussetts Medical Society, 2023-04-13)
    BACKGROUND: Bempedoic acid, an ATP citrate lyase inhibitor, reduces low-density lipoprotein (LDL) cholesterol levels and is associated with a low incidence of muscle-related adverse events; its effects on cardiovascular ...
  • Aptamers targeting von willebrand factor: What and why? 
    Schutgens, Roger E.G. (Wolters Kluwer Health, 2023-02-26)
  • MarioHeart: Novel In-Vitro Flow Model for Testing Heart Valve Prostheses and Anticoagulant Therapies 
    Devos, Maxime; Liesdek, Omayra C D; Suyker, Willem J L; van Tuijl, Sjoerd; Schutgens, Roger E G; van de Vosse, Frans N; de Heer, Linda M; Rutten, Marcel C M (Lippincott Williams & Wilkins, 2023-05-01)
    Mechanical heart valve (MHV) prostheses present a risk of thromboembolic complications despite antithrombotic therapy. Further steps in the development of more hemocompatible MHVs and new anticoagulants are impeded due to ...
  • Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis 
    Akbalut, Cengiz; Arisz, Ryanne; Baaten, Constance; Baildildinova, Gaukhar; Barakzie, Aarazo; Bauersachs, Rupert; Ten Berg, Jurriën M; van den Broek, Wout; de Boer, Hetty C; Broker, Vanessa; Buka, Richard; Ten Cate, Hugo; Cate, Arina Ten; De Luca, Ciro; De Simone, Ilaria; Dignat-George, Françoise; Freson, Kathleen; Gazzaniga, Giulia; van Gorp, Eric; Habibi, Anxhela; Henskens, Yvonne M C; Iding, Aaron F J; Khan, Abdullah; Koenderink, Gijsje; Konkoth, Akhil; Lacroix, Romaric; Lahiri, Trisha; Lam, Wilbur; Lamerton, Rachel; Lorusso, Roberto; Luo, Qi; Maas, Coen; McCarty, Owen J T; van der Meijden, Paola; Meijers, Joost; Mohapatra, Adarsh; Nevo, Neta; Pallares Robles, Alejandro; Poncelet, Philippe; Reinhardt, Christoph; Ruf, Wolfram; Saraswat, Ronald; Schonichen, Claudia; Schutgens, Roger E G; Simioni, Paolo; Spada, Stefano; Spronk, Henri M H; Tazhibayeva, Karlygash; Thachil, Jecko; Vacik-Diaz, Rocio; Veninga, Alicia; Verhamme, Peter; Visser, Chantal; Watson, Steve P; Wenzel, Philip; Willems, Ruth; Willers, Anne; Zhang, Pengyu; Zifkos, Konstantinos; van Zonneveld, Anton-Jan (Schattauer GmbH, 2023-08)
    The Fourth Maastricht Consensus Conference on Thrombosis included the following themes. Theme 1: The coagulome as a critical driver of cardiovascular disease. Blood coagulation proteins also play divergent roles in biology ...
  • The efficacy of the entire-vial dosing of emicizumab: Real-world evidence on plasma concentrations, bleeds, and drug waste 
    Donners, Anouk A.M.T.; van der Zwet, Konrad; Rademaker, Carin M.A.; Egberts, Toine C.G.; Schutgens, Roger E.G.; Fischer, Kathelijn (Elsevier, 2023-02)
    Background: Prophylaxis with emicizumab provides effective bleeding protection in persons with hemophilia A (PwHA) but pressures healthcare budgets. The body weight–adjusted dosing at 7-, 14-, or 28-day intervals, according ...
  • TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity 
    Gallego-Paez, Lina M; Edwards, William J S; Chanduri, Manasa; Guo, Yanyu; Koorman, Thijs; Lee, Chieh-Yu; Grexa, Nina; Derksen, Patrick; Yan, Jie; Schwartz, Martin A; Mauer, Jan; Goult, Benjamin Thomas (Rockefeller University Press, 2023-05-01)
    Talin-1 is the core mechanosensitive adapter protein linking integrins to the cytoskeleton. The TLN1 gene is comprised of 57 exons that encode the 2,541 amino acid TLN1 protein. TLN1 was previously considered to be expressed ...
  • Breaking the resolution limits of 3D bioprinting: future opportunities and present challenges 
    Zandrini, Tommaso; Florczak, Sammy; Levato, Riccardo; Ovsianikov, Aleksandr (Elsevier Limited, 2023-05)
    Bioprinting aims to produce 3D structures from which embedded cells can receive mechanical and chemical stimuli that influence their behavior, direct their organization and migration, and promote differentiation, in a ...
  • Programming Delayed Dissolution Into Sacrificial Bioinks For Dynamic Temporal Control of Architecture within 3D-Bioprinted Constructs 
    Soliman, Bram G.; Longoni, Alessia; Wang, Mian; Li, Wanlu; Bernal; Cianciosi, Alessandro; Lindberg, Gabriella C.J.; Malda, Jos; Groll, Juergen; Jungst, Tomasz; Levato, Riccardo; Rnjak-Kovacina, Jelena; Woodfield, Tim B.F.; Zhang, Yu Shrike; Lim, Khoon S. (Wiley-VCH Verlag, 2023-02-16)
    Sacrificial printing allows introduction of architectural cues within engineered tissue constructs. This strategy adopts the use of a 3D-printed sacrificial ink that is embedded within a bulk hydrogel which is subsequently ...
  • Harnessing light in biofabrication 
    Levato, Riccardo; Lim, Khoon S. (IOP Publishing Ltd., 2023-04)
    The integration of light-driven technologies into biofabrication has revolutionized the field of tissue engineering and regenerative medicine, with numerous breakthroughs in the last few years. Light-based bioprinting ...
  • Unmasking a silent killer: Prevalence of diagnosed and undiagnosed Diabetes Mellitus among people living with HIV in rural South Africa 
    de Vries, Annemiek E M; Xaba, Zanele; Moraba, Sehulong R; Goerlitz, Luise; Tempelman, Hugo A; Klipstein-Grobusch, Kerstin; Hermans, Lucas E; Scheuermaier, Karine; Devillé, Walter L J M; Vos, Alinda G (Wiley-Blackwell, 2023-05)
    OBJECTIVES: To document the prevalence of impaired glucose tolerance (IGT) and undiagnosed diabetes mellitus (DM) and to identify factors associated with undiagnosed DM in people living with HIV (PLWH). METHODS: Cross-sectional ...
  • Points to consider for cost-effective use of biological and targeted synthetic DMARDs in inflammatory rheumatic diseases: results from an umbrella review and international Delphi study 
    Van Der Togt, Céleste J.T.; Van Den Bemt, Bart; Aletaha, Daniel; Alten, Rieke; Chatzidionysiou, Katerina; Galloway, James; Isaac, John; Mulleman, Denis; Verschueren, P.; Vulto, Arnold G.; Welsing, Paco M.J.; Verhoef, Lise; Den Broeder, Alfons A. (BMJ Publishing Group, 2023-03-02)
    Objectives To develop evidence-based points to consider for cost-effective use of biological and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in the treatment of inflammatory rheumatic diseases, ...
  • Mind matters: A narrative review on affective state-dependency in non-invasive brain stimulation 
    Schutter, Dennis J.L.G.; Smits, Fenne; Klaus, Jana (Elsevier, 2023-07-01)
    Variability in findings related to non-invasive brain stimulation (NIBS) have increasingly been described as a result of differences in neurophysiological state. Additionally, there is some evidence suggesting that individual ...
  • Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease 
    Young, William J; Haessler, Jeffrey; Benjamins, Jan-Walter; Repetto, Linda; Yao, Jie; Isaacs, Aaron; Harper, Andrew R; Ramirez, Julia; Garnier, Sophie; van Duijvenboden, Stefan; Baldassari, Antoine R; Concas, Maria Pina; Duong, ThuyVy; Foco, Luisa; Isaksen, Jonas L; Mei, Hao; Noordam, Raymond; Nursyifa, Casia; Richmond, Anne; Santolalla, Meddly L; Sitlani, Colleen M; Soroush, Negin; Thériault, Sébastien; Trompet, Stella; Aeschbacher, Stefanie; Ahmadizar, Fariba; Alonso, Alvaro; Brody, Jennifer A; Campbell, Archie; Correa, Adolfo; Darbar, Dawood; De Luca, Antonio; Deleuze, Jean-François; Ellervik, Christina; Fuchsberger, Christian; Goel, Anuj; Grace, Christopher; Guo, Xiuqing; Hansen, Torben; Heckbert, Susan R; Jackson, Rebecca D; Kors, Jan A; Lima-Costa, Maria Fernanda; Linneberg, Allan; Macfarlane, Peter W; Morrison, Alanna C; Navarro, Pau; Porteous, David J; Pramstaller, Peter P; Reiner, Alexander P; Risch, Lorenz; Schotten, Ulrich; Shen, Xia; Sinagra, Gianfranco; Soliman, Elsayed Z; Stoll, Monika; Tarazona-Santos, Eduardo; Tinker, Andrew; Trajanoska, Katerina; Villard, Eric; Warren, Helen R; Whitsel, Eric A; Wiggins, Kerri L; Arking, Dan E; Avery, Christy L; Conen, David; Girotto, Giorgia; Grarup, Niels; Hayward, Caroline; Jukema, J Wouter; Mook-Kanamori, Dennis O; Olesen, Morten Salling; Padmanabhan, Sandosh; Psaty, Bruce M; Pattaro, Cristian; Ribeiro, Antonio Luiz P; Rotter, Jerome I; Stricker, Bruno H; van der Harst, Pim; van Duijn, Cornelia M; Verweij, Niek; Wilson, James G; Orini, Michele; Charron, Philippe; Watkins, Hugh; Kooperberg, Charles; Lin, Henry J; Wilson, James F; Kanters, Jørgen K; Sotoodehnia, Nona; Mifsud, Borbala; Lambiase, Pier D; Tereshchenko, Larisa G; Munroe, Patricia B (Nature Publishing Group, 2023-03-14)
    The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry ...
  • Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia 
    Tirtakusuma, Ricky; Szoltysek, Katarzyna; Milne, Paul; Grinev, Vasily V; Ptasinska, Anetta; Chin, Paulynn S; Meyer, Claus; Nakjang, Sirintra; Hehir-Kwa, Jayne Y; Williamson, Daniel; Cauchy, Pierre; Keane, Peter; Assi, Salam A; Ashtiani, Minoo; Kellaway, Sophie G; Imperato, Maria R; Vogiatzi, Fotini; Schweighart, Elizabeth K; Lin, Shan; Wunderlich, Mark; Stutterheim, Janine; Komkov, Alexander; Zerkalenkova, Elena; Evans, Paul; McNeill, Hesta; Elder, Alex; Martinez-Soria, Natalia; Fordham, Sarah E; Shi, Yuzhe; Russell, Lisa J; Pal, Deepali; Smith, Alex; Kingsbury, Zoya; Becq, Jennifer; Eckert, Cornelia; Haas, Oskar A; Carey, Peter; Bailey, Simon; Skinner, Roderick; Miakova, Natalia; Collin, Matthew; Bigley, Venetia; Haniffa, Muzlifah; Marschalek, Rolf; Harrison, Christine J; Cargo, Catherine A; Schewe, Denis; Olshanskaya, Yulia; Thirman, Michael J; Cockerill, Peter N; Mulloy, James C; Blair, Helen J; Vormoor, Josef; Allan, James M; Bonifer, Constanze; Heidenreich, Olaf; Bomken, Simon (Elsevier, 2022-10-27)
    The fusion gene MLL/AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukemia. Relapse can be associated with a lineage switch from acute lymphoblastic to acute myeloid leukemia, resulting in poor clinical ...
  • The MLL recombinome of acute leukemias in 2017 
    Meyer, C; Burmeister, T; Gröger, D; Tsaur, G; Fechina, L; Renneville, A; Sutton, R; Venn, N C; Emerenciano, M; Pombo-de-Oliveira, M S; Barbieri Blunck, C; Almeida Lopes, B; Zuna, J; Trka, J; Ballerini, P; Lapillonne, H; De Braekeleer, M; Cazzaniga, G; Corral Abascal, L; van der Velden, V H J; Delabesse, E; Park, T S; Oh, S H; Silva, M L M; Lund-Aho, T; Juvonen, V; Moore, A S; Heidenreich, O; Vormoor, J; Zerkalenkova, E; Olshanskaya, Y; Bueno, C; Menendez, P; Teigler-Schlegel, A; Zur Stadt, U; Lentes, J; Göhring, G; Kustanovich, A; Aleinikova, O; Schäfer, B W; Kubetzko, S; Madsen, H O; Gruhn, B; Duarte, X; Gameiro, P; Lippert, E; Bidet, A; Cayuela, J M; Clappier, E; Alonso, C N; Zwaan, C M; van den Heuvel-Eibrink, M M; Izraeli, S; Trakhtenbrot, L; Archer, P; Hancock, J; Möricke, A; Alten, J; Schrappe, M; Stanulla, M; Strehl, S; Attarbaschi, A; Dworzak, M; Haas, O A; Panzer-Grümayer, R; Sedék, L; Szczepański, T; Caye, A; Suarez, L; Cavé, H; Marschalek, R (Springer Nature, 2018-02-01)
    Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints ...
  • MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance 
    van der Zwet, Jordy C G; Buijs-Gladdines, Jessica G C A M; Cordo', Valentina; Debets, Donna O; Smits, Willem K; Chen, Zhongli; Dylus, Jelle; Zaman, Guido J R; Altelaar, Maarten; Oshima, Koichi; Bornhauser, Beat; Bourquin, Jean-Pierre; Cools, Jan; Ferrando, Adolfo A; Vormoor, Josef; Pieters, Rob; Vormoor, Britta; Meijerink, Jules P P (Springer Nature, 2021-12)
    (Patho-)physiological activation of the IL7-receptor (IL7R) signaling contributes to steroid resistance in pediatric T-cell acute lymphoblastic leukemia (T-ALL). Here, we show that activating IL7R pathway mutations and ...