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Educational activism for planetary health: a case example from The Netherlands

Mattijsen, Juliette C.; van Bree, Egid M.; Brakema, Evelyn A.; Huynen, Maud M.T.E.; Visser, Eva H.; Blankestijn, Peter J.; Elders, Philip N.D.; Ossebaard, Hans C. (Elsevier, 2023-01)
CT radiomics compared to a clinical model for predicting checkpoint inhibitor treatment outcomes in patients with advanced melanoma

Ter Maat, Laurens S; van Duin, Isabella A J; Elias, Sjoerd G; Leiner, Tim; Verhoeff, Joost J C; Arntz, Eran R A N; Troenokarso, Max F; Blokx, Willeke A M; Isgum, Ivana; de Wit, Geraldine A; van den Berkmortel, Franchette W P J; Boers-Sonderen, Marye J; Boomsma, Martijn F; van den Eertwegh, Fons J M; de Groot, Jan Willem B; Piersma, Djura; Vreugdenhil, Art; Westgeest, Hans M; Kapiteijn, Ellen; van Diest, Paul J; Pluim, Josien P W; de Jong, Pim A; Suijkerbuijk, Karijn P M; Veta, Mitko (Elsevier Limited, 2023-05)

Introduction: Predicting checkpoint inhibitors treatment outcomes in melanoma is a relevant task, due to the unpredictable and potentially fatal toxicity and high costs for society. However, accurate biomarkers for treatment ...
Individual elective lymph node irradiation for the reduction of complications in head and neck cancer patients (iNode): A phase-I feasibility trial protocol

Reinders, Floris C.J.; de Ridder, Mischa; Doornaert, Patricia A.H.; P.J. Raaijmakers, Cornelis; Philippens, Marielle E.P. (Elsevier Ireland Ltd, 2023-03)

Introduction: The long-term complication rate in head-and-neck squamous cell carcinoma (HNSCC) patients caused by radiotherapy (RT) can be decreased by restricting elective neck irradiation (ENI) from large adjacent lymph ...
Determinants of successful immune tolerance induction in hemophilia A: systematic review and meta-analysis

International Genetic and clinical determinants of the Outcome of Immune Tolerance Induction (GO-ITI) study group (Elsevier, 2023-01)

Background: Immune tolerance induction (ITI) aims to eradicate anti-factor VIII (FVIII) antibodies (inhibitors) in persons with hemophilia A. However, this burdensome treatment fails in 10% to 40%. To estimate the chance ...
Different inhibitor incidence for individual factor VIII concentrates in 1076 previously untreated patients with severe hemophilia A: data from the PedNet cohort

Fischer, Kathelijn; Carcao, Manuel; Male, Christoph; Ranta, Susanna; Pergantou, Helen; Kenet, Gili; Kartal-Kaess, Mutlu; Königs, Christoph; Carvalho, Manuela; Alvarez, Maria Teresa; Brakenhoff, Timo; Chambost, Hervé; van den Berg, H. Marijke (Wiley-Blackwell, 2023-03)
Magnetic resonance imaging evidence for subclinical joint bleeding in a Dutch population of people with severe hemophilia on prophylaxis

van Leeuwen, Flora H P; van Bergen, Eline D P; Timmer, Merel A; van Vulpen, Lize F D; Schutgens, Roger E G; de Jong, Pim A; Fischer, Kathelijn; Foppen, Wouter (Wiley-Blackwell, 2023-05)

Background: Previous studies suggest that subclinical bleeding occurs in persons with hemophilia. Objectives: The aim of this study was to investigate whether patients with lifelong access to prophylaxis showed signs of ...
Deep learning-based recognition of key anatomical structures during robot-assisted minimally invasive esophagectomy

den Boer, R B; Jaspers, T J M; de Jongh, C; Pluim, J P W; van der Sommen, F; Boers, T; van Hillegersberg, R; Van Eijnatten, M A J M; Ruurda, J P (Springer New York, 2023-07)

OBJECTIVE: To develop a deep learning algorithm for anatomy recognition in thoracoscopic video frames from robot-assisted minimally invasive esophagectomy (RAMIE) procedures using deep learning. BACKGROUND: RAMIE is a ...
Vulvovaginal yeast infections during pregnancy and perinatal outcomes: systematic review and meta-analysis

Gigi, Ranjana M S; Buitrago-Garcia, Diana; Taghavi, Katayoun; Dunaiski, Cara-Mia; van de Wijgert, Janneke H H M; Peters, Remco P H; Low, Nicola (BioMed Central, 2023-03-21)

Background: Vulvovaginal yeast infections in pregnancy are common and can cause extensive inflammation, which could contribute to adverse pregnancy outcomes. Symptomatic yeast infections are likely to cause more inflammation ...
BCG Vaccination of Health Care Workers Does Not Reduce SARS-CoV-2 Infections nor Infection Severity or Duration: a Randomized Placebo-Controlled Trial

BCG-Corona Study Group (American Society for Microbiology, 2023-04-25)

Bacillus Calmette-Guerin (BCG) vaccination has been hypothesized to reduce severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, severity, and/or duration via trained immunity induction. Health care workers ...
Overinterpretation of findings in machine learning prediction model studies in oncology: a systematic review

Dhiman, Paula; Ma, Jie; Andaur Navarro, Constanza L; Speich, Benjamin; Bullock, Garrett; Damen, Johanna AA; Hooft, Lotty; Kirtley, Shona; Riley, Richard D; Van Calster, Ben; Moons, Karel Gm; Collins, Gary S (Elsevier, 2023-05)

Objectives: In biomedical research, spin is the overinterpretation of findings, and it is a growing concern. To date, the presence of spin has not been evaluated in prognostic model research in oncology, including studies ...
Effect of Intravenous Ferric Carboxymaltose on Exercise Capacity After Kidney Transplantation (EFFECT-KTx): rationale and study protocol for a double-blind, randomised, placebo-controlled trial

Vinke, Joanna Sj; Eisenga, Michele F; Sanders, Jan-Stephan F; Berger, Stefan P; Spikman, Jacoba M; Abdulahad, Wayel H; Bakker, Stephan Jl; Gaillard, Carlo A J M; van Zuilen, Arjan D; van der Meer, P; de Borst, Martin H (BMJ Publishing Group, 2023-03-22)

Introduction Iron deficiency (ID) is common and has been associated with an excess mortality risk in kidney transplant recipients (KTRs). In patients with chronic heart failure and ID, intravenous iron improves exercise ...
Disease-Specific Quality Indicators for Outpatient Antibiotic Prescribing for Respiratory Infections (ESAC Quality Indicators) Applied to Point Prevalence Audit Surveys in General Practices in 13 European Countries

Vellinga, Akke; Luke-Currier, Addiena; Garzón-Orjuela, Nathaly; Aabenhus, Rune; Anastasaki, Marilena; Balan, Anca; Böhmer, Femke; Lang, Valerija Bralić; Chlabicz, Slawomir; Coenen, Samuel; García-Sangenís, Ana; Kowalczyk, Anna; Malania, Lile; Tomacinschii, Angela; van der Linde, Sanne R; Bongard, Emily; Butler, Christopher C; Goossens, Herman; van der Velden, Alike W (Multidisciplinary Digital Publishing Institute (MDPI), 2023-03-14)

Up to 80% of antibiotics are prescribed in the community. An assessment of prescribing by indication will help to identify areas where improvement can be made. A point prevalence audit study (PPAS) of consecutive respiratory ...
Melanocytoom, intermediair tussen naevus en melanoom

van den Broeke, Lieselotte R; Ebbelaar, Chiel F; Hayes, Donal P; Bousema, Mente T; Blokx, Willeke A M (Bohn Stafleu van Loghum, 2023-03-29)

The WHO classification of melanocytic skin tumours published in 2018 describes a new classification with nine different pathways based on molecular driver mutations, localization, clinical context and solar damage. The ...
Nine decades of electrocorticography: A comparison between epidural and subdural recordings

Branco, Mariana P; Geukes, Simon H; Aarnoutse, Erik J; Ramsey, Nick F; Vansteensel, Mariska J (Wiley-Blackwell, 2023-04)

In recent years, electrocorticography (ECoG) has arisen as a neural signal recording tool in the development of clinically viable neural interfaces. ECoG electrodes are generally placed below the dura mater (subdural) but ...
Diabetes—Tuberculosis Care in Eswatini: A Qualitative Study of Opportunities and Recommendations for Effective Services Integration

Williams, Victor; Vos-Seda, Alinda G.; Haumba, Samson; Mdluli-Dlamini, Lindiwe; Calnan, Marianne; Grobbee, Diederick E.; Otwombe, Kennedy; Klipstein-Grobusch, Kerstin (Frontiers Media S. A., 2023-03-30)

Objective: This study describes the availability of basic services, equipment, and commodities for integrated DM–TB services, best practices by healthcare workers, and opportunities for better integration of DM–TB care in ...
Neonatal sepsis and transient immunodeficiency: Potential for novel immunoglobulin therapies?

Beudeker, Coco R.; Vijlbrief, Daniel C.; van Montfrans, Joris M; Rooijakkers, Suzan H.M.; Flier, Michiel van der (Frontiers Media S. A., 2022-10-18)

Neonates, especially preterm neonates, have the highest risk of sepsis of all age groups. Transient immaturity of the neonatal immune system is an important risk factor. Neonates suffer from hypogammaglobulinemia as nor ...
Purified complement C3b triggers phagocytosis and activation of human neutrophils via complement receptor 1

Boero, Elena; Gorham, Ronald D.; Francis, Emmet A.; Brand, Jonathan; Teng, Lay Heng; Doorduijn, Dennis J.; Ruyken, Maartje; Muts, Remy M.; Lehmann, Christian; Verschoor, Admar; van Kessel, Kok P.M.; Heinrich, Volkmar; Rooijakkers, Suzan H.M. (Nature Publishing Group, 2023-01-06)

The complement system provides vital immune protection against infectious agents by labeling them with complement fragments that enhance phagocytosis by immune cells. Many details of complement-mediated phagocytosis remain ...
Monitoring phage-induced lysis of gram-negatives in real time using a fluorescent DNA dye

Egido, Julia E.; Toner-Bartelds, Catherine; Costa, Ana Rita; Brouns, Stan J.J.; Rooijakkers, Suzan H.M.; Bardoel, Bart W.; Haas, Pieter Jan (Nature Publishing Group, 2023-01-16)

Bacteriophages (phages) are viruses that specifically attack bacteria. Their use as therapeutics, which constitutes a promising alternative to antibiotics, heavily relies on selecting effective lytic phages against the ...
Genome-wide screen in human plasma identifies multifaceted complement evasion of Pseudomonas aeruginosa

Janet-Maitre, Manon; Pont, Stéphane; Masson, Frerich M.; Sleiman, Serena; Trouillon, Julian; Robert-Genthon, Mylène; Gallet, Benoît; Dumestre-Perard, Chantal; Elsen, Sylvie; Moriscot, Christine; Bardoel, Bart W.; Rooijakkers, Suzan H.M.; Cretin, François; Attrée, Ina (Public Library of Science, 2023-01)

Pseudomonas aeruginosa, an opportunistic Gram-negative pathogen, is a leading cause of bacteremia with a high mortality rate. We recently reported that P. aeruginosa forms a persister-like sub-population of evaders in human ...
Evaluating the Targeting of a Staphylococcus-aureus-Infected Implant with a Radiolabeled Antibody In Vivo

van Dijk, Bruce; Hooning van Duyvenbode, J. Fred F.; de Vor, Lisanne; Nurmohamed, F. Ruben H.A.; Lam, Marnix G.E.H.; Poot, Alex J.; Ramakers, Ruud M.; Koustoulidou, Sofia; Beekman, Freek J.; van Strijp, Jos; Rooijakkers, Suzan H.M.; Dadachova, Ekaterina; Vogely, H. Charles; Weinans, Harrie; van der Wal, Bart C.H. (Multidisciplinary Digital Publishing Institute (MDPI), 2023-03)

Implant infections caused by Staphylococcus aureus are difficult to treat due to biofilm formation, which complicates surgical and antibiotic treatment. We introduce an alternative approach using monoclonal antibodies ...

Now showing items 10241-10260 of 40729