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Clinical development of WEE1 inhibitors in gynecological cancers: A systematic review

Schutte, Tim; Embaby, Alaa; Steeghs, Neeltje; van der Mierden, Stevie; van Driel, Willemien; Rijlaarsdam, Martin; Huitema, Alwin; Opdam, Frans (W.B. Saunders Ltd, 2023-04)

Introduction: The anti-tumor activity of WEE1 inhibitors (WEE1i) in gynecological malignancies has recently been demonstrated in clinical trials and its rationale is based on biological/molecular features of gynecological ...
Therapeutic drug monitoring guided dosing versus standard dosing of alectinib in advanced ALK positive non-small cell lung cancer patients: Study protocol for an international, multicenter phase IV randomized controlled trial (ADAPT ALEC)

Meertens, Marinda; Muntinghe-Wagenaar, M. Benthe; Sikkema, Barend J.; Lopez-Yurda, Marta; Retèl, Valesca P.; Paats, Marthe S.; Ter Heine, Rob; Schuuring, Ed; Timens, Wim; Touw, Daan J.; van Boven, Job F.M.; de Langen, Adrianus J.; Hashemi, Sayed M.S.; Hendriks, Lizza E.L.; Croes, Sander; van den Heuvel, Michel M.; Dingemans, Anne Marie C.; Mathijssen, Ron H.J.; Smit, Egbert F.; Huitema, Alwin D.R.; Steeghs, Neeltje; van der Wekken, Anthonie J. (Frontiers Media S. A., 2023)

BACKGROUND: Alectinib is first-line therapy in patients with stage IV non-small cell lung carcinoma (NSCLC) and an anaplastic lymphoma kinase (ALK) fusion. A shorter median progression-free survival (mPFS) was observed ...
Biological Tipping Point in Patients with Atopic Dermatitis Treated with Different Dosing Intervals of Dupilumab

Dekkers, Coco; van der Wal, M Marlot; El Amrani, Mohsin; van Luin, Matthijs; Bakker, Daphne S; de Bruin-Weller, Marjolein; van Wijk, Femke (Elsevier, 2023-09)
Risk Factors for Cholangitis After Pancreatoduodenectomy: A Systematic Review

Salaheddine, Youcef; Henry, Anne Claire; Daamen, Lois A; Derksen, Wouter J M; van Lienden, Krijn P; Molenaar, I Quintus; van Santvoort, Hjalmar C; Vleggaar, Frank P; Verdonk, Robert C (Springer New York, 2023-07)

BACKGROUND: Cholangitis is a late complication after pancreatoduodenectomy with considerable clinical impact and is difficult to treat. The aim of this systematic review was to provide an overview of the literature identifying ...
Physical training and high protein diet improved muscle strength, parent-reported fatigue and physical quality of life in children with Pompe disease

exercise team. (Springer Netherlands, 2023-07)

Exercise has proven to be an effective adjuvant treatment to enzyme replacement therapy (ERT) in mildly affected adult Pompe patients. The aim of this study was to investigate the effects of a 12-week tailored lifestyle ...
Low dose emicizumab prophylaxis in haemophilia a patients: A pilot study from India

Bansal, Shweta; Donners, Anouk A.M.T.; Fischer, Kathelijn; Kshirsagar, Shrinath; Rangarajan, Savita; Phadke, Varsha; Mhatre, Shrutika; Sontate, Bharati; silva, Magdelene D’; Ansari, Shahana; Shetty, Shrimati (Wiley-Blackwell, 2023-05)
Diabetes mellitus is associated with 90-day mortality in old critically ill COVID-19 patients: a multicenter prospective observational cohort study

COVIP study group (Urban und Vogel, 2023-10)

Background: Several studies have found an association between diabetes mellitus, disease severity and outcome in COVID-19 patients. Old critically ill patients are particularly at risk. This study aimed to investigate the ...
Incidence of cardiovascular symptoms and adverse events following self-reported acute cannabis intoxication at the emergency department: a retrospective study

Gresnigt, Femke; van den Brink, Lianne C; Hunault, Claudine; Franssen, Eric; de Lange, Dylan; Riezebos, Robert (BMJ Publishing Group, 2023-05)
World Marrow Donor Association guidelines for the reporting of novel HLA alleles

Hofmann, Jan A; Bochtler, Werner; Robinson, James; Sauter, Jürgen; Askar, Medhat; Houdova, Lucie; Melchers, Mark; Schmidt, Alexander H; Spierings, Eric; Urban, Christine; Venter, Alicia; Maiers, Martin; Marsh, Steven G E; Eberhard, Hans-Peter (Wiley-Blackwell, 2023-07)

The guidelines for the implementation and reporting of HLA nomenclature for the World Marrow Donor Association have served as a reliable standard for communication of HLA data in the hematopoietic cell transplantation ...
Erratum: A musculoskeletal finite element model of rat knee joint for evaluating cartilage biomechanics during gait (PLoS Computational Biology (2022) 18:6 (e1009398) DOI: 10.1371/journal.pcbi.1009398)

Orozco, Gustavo A; Karjalainen, Kalle; Moo, Eng Kuan; Stenroth, Lauri; Tanska, Petri; Rios, Jaqueline Lourdes; Tuomainen, Teemu V; Nissi, Mikko J; Isaksson, Hanna; Herzog, Walter; Korhonen, Rami K (Public Library of Science, 2023-03)

The Funding statement is incomplete. The complete Funding statement is as follows: Academy of Finland (https://www.aka.fi/en; grant nos. 285909 [MJN], 324529 [RKK], 332915 [LS], 334773—under the frame of ERA PerMed [RKK]), ...
Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support–Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial

REMAP-CAP Investigators (American Medical Association, 2023-04-11)

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. OBJECTIVE To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin ...
Arthroscopic synovectomy versus intra-articular injection of corticosteroids for the management of refractory psoriatic or rheumatoid arthritis of the wrist: study protocol for a randomized controlled trial (ARCTIC trial)

d’Ailly, P. N.; Deugd, C.; Schep, N. W.L.; Kuijper, T. M.; Kok, M. R.; Willemze, A.; Coert, J. H.; de Jong, P. H.P.; Lam-Tse, W. K.; van der Helm-van Mil, A. H.M.; Tchetverikov, I.; Weel-Koenders, A. E.A.M.; Bisoendial, R. J. (BioMed Central, 2023-03-25)

Background: Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are inflammatory diseases that often affect the wrist and, when affected, can lead to impaired wrist function and progressive joint destruction if ...
Effects of a brief compassion exercise on affect and emotion regulation in patients with personality disorders

Sommers-Spijkerman, Marion; Radstaak, Mirjam; Chakhssi, Farid (Elsevier, 2023-03)

Background and objectives: Cultivating compassion seems a promising strategy for ameliorating emotion dysregulation in patients with personality disorders (PDs). Thus far, empirical evidence is lacking. This study aimed ...
Automated spike and seizure detection: are we ready for implementation?

Reus, E.E.M.; Visser, G.H.; Sommers-Spijkerman, M.P.J.; Van Dijk, J.G.; Cox, F.M.E. (W.B. Saunders Ltd, 2023-05)

Objective: Automated detection of spikes and seizures has been a subject of research for several decades now. There have been important advances, yet automated detection in EMU (Epilepsy Monitoring Unit) settings has not ...
Additional Value of 3-Month Cranial Magnetic Resonance Imaging in Infants with Neonatal Encephalopathy following Perinatal Asphyxia

Parmentier, Corline E.J.; Lequin, Maarten H.; Alderliesten, Thomas; Swanenburg de Veye, Henriëtte F.N.; van der Aa, Niek E.; Dudink, Jeroen; Benders, Manon J.N.L.; Harteman, Johanna C.; Koopman-Esseboom, Corine; Groenendaal, Floris; de Vries, Linda S. (Mosby Inc., 2023-07)

Objective: To assess the evolution of neonatal brain injury noted on magnetic resonance imaging (MRI), develop a score to assess brain injury on 3-month MRI, and determine the association of 3-month MRI with neurodevelopmental ...
From computer to bedside, involving neonatologists in artificial intelligence models for neonatal medicine

Vijlbrief, Daniel; Dudink, Jeroen; van Solinge, Wouter; Benders, Manon; Haitjema, Saskia (Lippincott Williams & Wilkins, 2023-01)

Abstract: In recent years, data have become the main driver of medical innovation. With increased availability and decreased price of storage and computing power, the potential for improvement in care is enormous. Many ...
Communicating diagnoses to individuals with a first episode psychosis: A qualitative study of individuals perspectives

Huurman, Marina Elisabeth; Pijnenborg, Gerdina Hendrika Maria; Sportel, Bouwina Esther; van Rijsbergen, Gerard David; Hasson-Ohayon, Ilanit; Boonstra, Nynke (Frontiers Research Foundation, 2023)

BACKGROUND: Receiving the label of a psychotic disorder influences self-perception and may result in negative outcomes such as self-stigma and decreased self-esteem. The way the diagnosis is communicated to individuals may ...
A Human-Centered Design Approach to Develop Oral Health Nursing Interventions in Patients with a Psychotic Disorder

Kuipers, Sonja; Castelein, Stynke; Kronenberg, Linda; Veer, Job van 't; Boonstra, Nynke (Multidisciplinary Digital Publishing Institute (MDPI), 2023-02-16)

In mental health, oral health is often given little attention. Mental health nurses (MHNs) are professionally the appropriate target group to support maintaining and increasing oral health. We aimed to develop and validate ...
The RESISTANT study (Respiratory Muscle Training in Patients with Spinal Muscular Atrophy): study protocol for a randomized controlled trial

Kant-Smits, Kim; Bartels, Bart; Asselman, Fay Lynn; Veldhoen, Esther S.; van Eijk, Ruben P.A.; van der Pol, W. Ludo; Hulzebos, Erik H.J. (BioMed Central, 2023-03-23)

Background: Spinal Muscular Atrophy (SMA) is characterized by progressive and predominantly proximal and axial muscle atrophy and weakness. Respiratory muscle weakness results in impaired cough with recurrent respiratory ...
Effect of biopsy protocol adherence vs non-adherence on dysplasia detection rates in Barrett's esophagus surveillance endoscopies: a systematic review and meta-analysis

Beaufort, Ilse; Weusten, Bas (Georg Thieme Verlag, 2023-03)

Background Barrett's esophagus (BE) surveillance endoscopies are advised for early diagnosis of esophageal adenocarcinoma (EAC). Current guidelines recommend obtaining four-quadrant random biopsies every 2 centimeters of ...

Now showing items 10161-10180 of 40729