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UMC Repository: Recent submissions

  • Effect of tissue-grouped regulatory variants associated to type 2 diabetes in related secondary outcomes 
    Hemerich, Daiane; Smit, Roelof A J; Preuss, Michael; Stalbow, Lauren; van der Laan, Sander W; Asselbergs, Folkert W; van Setten, Jessica; Tragante, Vinicius (Nature Publishing Group, 2023-12)
    Genome-wide association studies have identified over five hundred loci that contribute to variation in type 2 diabetes (T2D), an established risk factor for many diseases. However, the mechanisms and extent through which ...
  • Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity 
    Schmidt, Amand F; Bourfiss, Mimount; Alasiri, Abdulrahman; Puyol-Anton, Esther; Chopade, Sandesh; van Vugt, Marion; van der Laan, Sander W; Gross, Christian; Clarkson, Chris; Henry, Albert; Lumbers, Tom R; van der Harst, Pim; Franceschini, Nora; Bis, Joshua C; Velthuis, Birgitta K; Te Riele, Anneline S J M; Hingorani, Aroon D; Ruijsink, Bram; Asselbergs, Folkert W; van Setten, Jessica; Finan, Chris (American Association for the Advancement of Science, 2023-04-28)
    Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent morbidity and mortality. We performed a genome-wide association study (GWAS) of 16 cardiac magnetic resonance (CMR) imaging ...
  • Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization 
    Zheng, Jie; Wheeler, Eleanor; Pietzner, Maik; Andlauer, Till F M; Yau, Michelle S; Hartley, April E; Brumpton, Ben Michael; Rasheed, Humaira; Kemp, John P; Frysz, Monika; Robinson, Jamie; Reppe, Sjur; Prijatelj, Vid; Gautvik, Kaare M; Falk, Louise; Maerz, Winfried; Gergei, Ingrid; Peyser, Patricia A; Kavousi, Maryam; de Vries, Paul S; Miller, Clint L; Bos, Maxime; van der Laan, Sander W; Malhotra, Rajeev; Herrmann, Markus; Scharnagl, Hubert; Kleber, Marcus; Dedoussis, George; Zeggini, Eleftheria; Nethander, Maria; Ohlsson, Claes; Lorentzon, Mattias; Wareham, Nick; Langenberg, Claudia; Holmes, Michael V; Smith, George Davey; Tobias, Jonathan H (John Wiley & Sons Inc., 2023-10)
    Objective: In this study, we aimed to establish the causal effects of lowering sclerostin, target of the antiosteoporosis drug romosozumab, on atherosclerosis and its risk factors. Methods: A genome-wide association study ...
  • Perceived facilitators and barriers by esophageal cancer survivors participating in a post-treatment exercise program 
    van Vulpen, Jonna K; Witlox, Lenja; Methorst-de Haan, Alida C; Hiensch, Anouk E; van Hillegersberg, Richard; Ruurda, Jelle P; Nieuwenhuijzen, Grard A P; Kouwenhoven, Ewout A; Siersema, Peter D; May, Anne M (Springer-Verlag, 2023-05-06)
    Purpose: Participation in a post-treatment exercise program improves cardiorespiratory fitness and aspects of quality of life for esophageal cancer survivors. For optimal effects, high adherence to the exercise intervention ...
  • Laparoscopic ischemic conditioning prior esophagectomy in selected patients: the ISCON trial 
    de Groot, Eline; Schiffmann, Lars M; van der Veen, Arjen; Borggreve, Alicia; de Jong, Pim; Dos Santos, Daniel Pinto; Babic, Benjamin; Fuchs, Hans; Ruurda, Jelle; Bruns, Christiane; van Hillegersberg, Richard; Schröder, Wolfgang (Wiley-Blackwell, 2023-10-27)
    Anastomotic leakage (AL) after esophagectomy is the most impactful complication after esophagectomy. Ischemic conditioning (ISCON) of the stomach >14 days prior to esophagectomy might reduce the incidence of AL. The current ...
  • Mammalian life depends on two distinct pathways of DNA damage tolerance 
    Buoninfante, Olimpia Alessandra; Pilzecker, Bas; Spanjaard, Aldo; de Groot, Daniël; Prekovic, Stefan; Song, Ji-Ying; Lieftink, Cor; Ayidah, Matilda; Pritchard, Colin E J; Vivié, Judith; Mcgrath, Kathleen E; Huijbers, Ivo J; Philipsen, Sjaak; von Lindern, Marieke; Zwart, Wilbert; Beijersbergen, Roderick L; Palis, James; van den Berk, Paul C M; Jacobs, Heinz (National Academy of Sciences, 2023-01-24)
    DNA damage threatens genomic integrity and instigates stem cell failure. To bypass genotoxic lesions during replication, cells employ DNA damage tolerance (DDT), which is regulated via PCNA ubiquitination and REV1. DDT is ...
  • The Tumor Coagulome as a Transcriptional Target and a Potential Effector of Glucocorticoids in Human Cancers 
    Racine, Floriane; Louandre, Christophe; Godin, Corinne; Chatelain, Baptiste; Prekovic, Stefan; Zwart, Wilbert; Galmiche, Antoine; Saidak, Zuzana (Multidisciplinary Digital Publishing Institute (MDPI), 2023-03)
    BACKGROUND: The coagulome, defined as the repertoire of genes that locally regulate coagulation and fibrinolysis, is a key determinant of vascular thromboembolic complications of cancer. In addition to vascular complications, ...
  • PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription 
    Mayayo-Peralta, Isabel; Gregoricchio, Sebastian; Schuurman, Karianne; Yavuz, Selçuk; Zaalberg, Anniek; Kojic, Aleksandar; Abbott, Nina; Geverts, Bart; Beerthuijzen, Suzanne; Siefert, Joseph; Severson, Tesa M; van Baalen, Martijn; Hoekman, Liesbeth; Lieftink, Cor; Altelaar, Maarten; Beijersbergen, Roderick L; Houtsmuller, Adriaan B; Prekovic, Stefan; Zwart, Wilbert (Oxford University Press, 2023-10-13)
    How steroid hormone receptors (SHRs) regulate transcriptional activity remains partly understood. Upon activation, SHRs bind the genome together with a co-regulator repertoire, crucial to induce gene expression. However, ...
  • Lymphatic Invasion of Plakoglobin-Dependent Tumor Cell Clusters Drives Formation of Polyclonal Lung Metastases in Colon Cancer 
    Küçükköse, Emre; Laoukili, Jamila; Gorelick, Alexander N.; Degner, Sebastian; Laclé, Miangela M.; van den Bent, Lotte; Peters, Niek A.; Verheem, André; Hung, Wei Ting; Frenkel, Nicola C.; Wassenaar, Emma C.E.; Lansu, Nico; Lenos, Kristiaan J.; Vermeulen, Louis; Koopman, Miriam; Roodhart, Jeanine M.L.; Kops, Geert J.P.L.; Borel Rinkes, Inne H.M.; Hagendoorn, Jeroen; Naxerova, Kamila; Kranenburg, Onno (W.B. Saunders, 2023-08)
    Background & Aims: Patients with colon cancer with liver metastases may be cured with surgery, but the presence of additional lung metastases often precludes curative treatment. Little is known about the processes driving ...
  • Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer 
    Mertens, Sander; Huismans, Maarten A; Verissimo, Carla S; Ponsioen, Bas; Overmeer, Rene; Proost, Natalie; van Tellingen, Olaf; van de Ven, Marieke; Begthel, Harry; Boj, Sylvia F; Clevers, Hans; Roodhart, Jeanine M L; Bos, Johannes L; Snippert, Hugo J G (Cell Press, 2023-04-25)
    Patient-derived organoids (PDOs) are widely heralded as a drug-screening platform to develop new anti-cancer therapies. Here, we use a drug-repurposing library to screen PDOs of colorectal cancer (CRC) to identify hidden ...
  • A Case of Yellow Airway Secretions and Oral Fluid 
    Zuidhof, Hidde R; van Schelt, Martijn; Roodhart, Jeanine M L; Ten Berg, Maarten J; Kemperman, Hans (Oxford University Press, 2023-05-01)
  • Displaying concerns within telephone triage conversations of callers with chest discomfort in out-of-hours primary care: A conversation analytic study 
    Spek, Michelle; van Charldorp, Tessa C; Vinck, Vera V; Venekamp, Roderick P; Rutten, Frans H; Zwart, Dorien LM; de Groot, Esther (Elsevier Ireland Ltd, 2023-08)
    OBJECTIVES: In primary care out of hours service (OHS-PC), triage nurses ask questions to assign urgency level for medical assessment. A semi-automatic decision tool (the Netherlands Triage Standard, NTS) facilitates triage ...
  • Exploring Interprofessional Development of Entrustable Professional Activities For Pediatric Intensive Care Fellows: A Proof-of-Concept Study 
    van Keulen, Sabrina G; de Raad, Timo; Raymakers-Janssen, Paulien; Ten Cate, Olle; Hennus, Marije P (Routledge, 2024)
    Phenomenon : Entrustable professional activities (EPAs) delineate major professional activities that an individual in a given specialty must be "entrusted" to perform, ultimately without supervision, to provide quality ...
  • Prolonged Opioid Use and Pain Outcome and Associated Factors after Surgery under General Anesthesia: A Prospective Cohort Association Multicenter Study 
    Multicenter Perioperative Outcomes Group Enhanced Observation Study Investigator Group for the Multicenter Perioperative Outcomes Group Enhanced Observation Study Collaborator Group (Lippincott Williams & Wilkins, 2023-05-01)
    Background: There is insufficient prospective evidence regarding the relationship between surgical experience and prolonged opioid use and pain. The authors investigated the association of patient characteristics, surgical ...
  • Stability and comparison of complete blood count parameters between capillary and venous blood samples 
    Doeleman, Martijn J.H.; Esseveld, Anouk; Huisman, Albert; de Roock, Sytze; Tiel Groenestege, Wouter M. (Wiley-Blackwell, 2023-10)
    Introduction: This study assessed the comparability of complete blood count (CBC) parameters between capillary and venous samples, and extended previous research by examining the influence of different storage temperatures ...
  • A kinesin-based approach for inducing chromosome-specific mis-segregation in human cells 
    Truong, My Anh; Cané-Gasull, Paula; de Vries, Sippe G.; Nijenhuis, Wilco; Wardenaar, René; Kapitein, Lukas C.; Foijer, Floris; Lens, Susanne M.A. (Springer Science and Business Media Deutschland GmbH, 2023-05-15)
    Various cancer types exhibit characteristic and recurrent aneuploidy patterns. The origins of these cancer type-specific karyotypes are still unknown, partly because introducing or eliminating specific chromosomes in human ...
  • High bleeding risk in patients undergoing percutaneous coronary intervention with drug-eluting stent implantation: ReCre8 subanalysis 
    The ReCre8 Study Investigators (Elsevier, 2022-12)
    Objectives: In an all-comers cohort undergoing percutaneous coronary intervention (PCI), we aimed to assess prevalence of high bleeding risk (HBR) patients and impact of HBR and dual antiplatelet therapy (DAPT) on clinical ...
  • Health-state utilities in long-term advanced melanoma survivors comparable with the general population 
    Egeler, M D; van de Poll-Franse, L V; Tissier, R; Rogiers, A; Boers-Sonderen, M J; van den Eertwegh, A J; Hospers, G A; de Groot, J W B; Aarts, M J B; Kapiteijn, E; Piersma, D; Vreugdenhil, G; van der Veldt, A A; Suijkerbuijk, K P M; Neyns, B; Janssen, K J; Blank, C U; Retèl, V P; Boekhout, A H (Springer Netherlands, 2023-09)
    BACKGROUND: Checkpoint inhibitors have been shown to substantially improve the survival of patients with advanced melanoma. With this growing group of survivors treated with immunotherapies, assessing their health-state ...
  • Real-world Outcomes of Ipilimumab Plus Nivolumab Combination Therapy in a Nation-wide Cohort of Advanced Melanoma Patients in the Netherlands 
    van Zeijl, Michiel C T; van Breeschoten, Jesper; de Wreede, Liesbeth C; Wouters, Michel W J M; Hilarius, Doranne L; Blank, Christian U; Aarts, Maureen J B; van den Berkmortel, Franchette W P J; de Groot, Jan Willem B; Hospers, Geke A P; Kapiteijn, Ellen; Piersma, Djura; van Rijn, Rozemarijn S; Stevense-den Boer, Marion A; van der Veldt, Astrid A M; Vreugdenhil, Gerard; Boers-Sonderen, Marye J; Suijkerbuijk, Karijn P M; Haanen, John B A G; van den Eertwegh, Alfons J M (Landes Bioscience, 2023-06-01)
    In phase III trials, ipilimumab plus nivolumab combination therapy is highly efficacious for advanced melanoma, despite many treatment-related grades 3-4 adverse events. Here, we report real-world safety and survival ...
  • Safety and technical efficacy of early minimally invasive endoscopy-guided surgery for intracerebral haemorrhage: the Dutch Intracerebral haemorrhage Surgery Trial pilot study 
    On behalf of the Dutch ICH Surgery Trial Study Group, part of the CONTRAST consortium (Springer, 2023-06)
    Background: Previous randomised controlled trials could not demonstrate that surgical evacuation of intracerebral haemorrhage (ICH) improves functional outcome. Increasing evidence suggests that minimally invasive surgery ...