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UMC Repository: Recent submissions

  • Wekesah, Frederick Murunga (Utrecht University, 2019-11-25)
    Approximately 27% of Kenya’s 50 million people live in urban areas. The majority (56%) live in slums or slum-like settings, with limited access to functional [public] health care in a setting where poverty and insecurity ...
  • Broekema, Marjoleine Fréderique (Utrecht University, 2019-12-03)
    Over the past 40 years the global prevalence of obesity has increased dramatically. With the emergence of the global obesity epidemic and its related metabolic complications, including insulin resistance, type 2 diabetes ...
  • Shcherbakova, Yulia (Utrecht University, 2019-12-05)
    Recent years have witnessed a considerable interest in quantitative Magnetic Resonance Imaging (qMRI), which aims to map quantitative imaging biomarkers (QIBs) representing underlying biological and physiological tissue ...
  • Lemstra, Suzanne (Utrecht University, 2019-12-19)
    During development, the brain develops from a few cells to a highly connected and complex organ containing ±170 billion communication-cells (neurons) and as many or more supporting-cells. Neurons connect to other neurons ...
  • Hwong, Wen Yea (Utrecht University, 2019)
    There has been a rapid escalation in the burden of stroke, in particular across low- and middle-income countries. Malaysia, being an upper-middle income country is of no exception to this crisis. Stroke has consistently ...
  • Zimmermann, Wesselius Oncke (Ministry of Defense, 2019-11-26)
    This thesis aimed to explore the utility of new and promising treatment forms for Exercise Related Leg Pain (ERLP) in the Royal Netherlands Armed Forces: Extracorporeal Shockwave Therapy (ESWT) for Medial Tibial Stress ...
  • Visser, Els (Utrecht University, 2019-11-28)
    Esophageal cancer is a highly aggressive disease with a rising incidence, especially in the Western World. Survival has improved over the last decades in which multimodality treatment played an important role. Despite these ...
  • van Ginkel, Joost Henri (Utrecht University, 2019-12-03)
    Head and neck cancers remain difficult to treat due to their aggressive biological behavior and delicate functional anatomy from which they arise. This particularly applies for advanced and recurrent cases, when feasible ...
  • Hoogenboom, Wouter Simon (Utrecht University, 2019-12-17)
    DNA interstrand crosslinks (ICLs) are lesions on the DNA that covalently attach both strands of the double helix. ICLs are very toxic to cells since important cellular processes such as DNA replication and transcription ...
  • Kotte, Elles Maria Willemien (2019-11-14)
    PART 1. FITKIDS INTERVENTION In chapter 3, the effects of the Fitkids intervention were investigated in a cross-sectional observational study. Children and adolescents with CMCs received a graded exercise program for 6 ...
  • Kahaleh, Lara Andrea (Utrecht University, 2019-11-27)
    Missing outcome data of trial participants is a frequent phenomenon in RCTs and may represent a serious potential source of bias if not reported and handled appropriately. The potential effect of bias associated with missing ...
  • Post, Jasmin Barry (Utrecht University, 2019-12-03)
    In metastatic colorectal cancer (mCRC), resistance to EGFR-targeted therapy is associated with MAPK pathway activating mutations. As a result, mCRC patients with such mutations, like oncogenic RAS, are currently excluded ...
  • Mfarrej, Bechara (Utrecht University, 2019-11-29)
    Cell-based immunotherapies address a number of unmet medical needs and some have shown success. All cell-based immunotherapy products undergo extensive preclinical and proof-of-concept investigations for only a few to reach ...
  • Kammen, Mayte Sánchez van; Greving, Jacoba P; Kuroda, Satoshi; Kashiwazaki, Daina; Morita, Akio; Shiokawa, Yoshiaki; Kimura, Toshikazu; Cognard, Christophe; Januel, Anne C; Lindgren, Antti; Koivisto, Timo; Jääskeläinen, Juha E; Ronkainen, Antti; Pyysalo, Liisa; Öhman, Juha; Rahi, Melissa; Kuhmonen, Johanna; Rinne, Jaakko; Leemans, Eva L; Majoie, Charles B; Vandertop, W Peter; Verbaan, Dagmar; Roos, Yvo B W E M; Berg, René van den; Boogaarts, Hieronymus D; Moudrous, Walid; Wijngaard, Ido R van den; Hove, Laura Ten; Teo, Mario; George, Edward J St; Hackenberg, Katharina A M; Abdulazim, Amr; Etminan, Nima; Rinkel, Gabriël J E; Vergouwen, Mervyn D I (Lippincott Williams and Wilkins, 2019-09)
    Background and PURPOSE: Prediction of intracranial aneurysm growth risk can assist physicians in planning of follow-up imaging of conservatively managed unruptured intracranial aneurysms. We therefore aimed to externally ...
  • His, Mathilde; Viallon, Vivian; Dossus, Laure; Gicquiau, Audrey; Achaintre, David; Scalbert, Augustin; Ferrari, Pietro; Romieu, Isabelle; Onland-Moret, N Charlotte; Weiderpass, Elisabete; Dahm, Christina C; Overvad, Kim; Olsen, Anja; Tjønneland, Anne; Fournier, Agnès; Rothwell, Joseph A; Severi, Gianluca; Kühn, Tilman; Fortner, Renée T; Boeing, Heiner; Trichopoulou, Antonia; Karakatsani, Anna; Martimianaki, Georgia; Masala, Giovanna; Sieri, Sabina; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; van Gils, Carla H; Nøst, Therese H; Sandanger, Torkjel M; Skeie, Guri; Quirós, J Ramón; Agudo, Antonio; Sánchez, Maria-Jose; Amiano, Pilar; Huerta, José María; Ardanaz, Eva; Schmidt, Julie A; Travis, Ruth C; Riboli, Elio; Tsilidis, Konstantinos K; Christakoudi, Sofia; Gunter, Marc J; Rinaldi, Sabina (BioMed Central, 2019-09-24)
    BACKGROUND: Metabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in ...
  • Berner-Rodoreda, Astrid; Rehfuess, Eva Annette; Klipstein-Grobusch, Kerstin; Cobelens, Frank; Raviglione, Mario; Flahaut, Antoine; Casamitjana, Núria; Fröschl, Günter; Skordis-Worral, Jolene; Abubakar, Ibrahim; Ashrafian, Hutan; Agardh, Anette; Visser, Leo; Schultsz, Constance; Plasència, Antoni; Jahn, Albrecht; Norton, Robyn; van Leeuwen, Remko; Hagander, Lars; Bärnighausen, Till (BMJ Publishing Group, 2019-10-01)
    Global Health has not featured as prominently in the European Union (EU) research agenda in recent years as it did in the first decade of the new millennium, and participation of low-income and middle-income countries ...
  • Zulian, Francesco; Culpo, Roberta; Sperotto, Francesca; Anton, Jordi; Avcin, Tadej; Baildam, Eileen M.; Boros, Christina; Chaitow, Jeffrey; Constantin, Tamàs; Kasapcopur, Ozgur; Knupp Feitosa De Oliveira, Sheila; Pilkington, Clarissa A.; Russo, Ricardo; Toplak, Natasa; Van Royen, Annet; Saad Magalhães, Claudia; Vastert, Sebastiaan J.; Wulffraat, Nico M.; Foeldvari, Ivan (BMJ Publishing Group, 2019-08-01)
    In 2012, a European initiative called Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic and management regimens in Europe for children and young ...
  • Barré, Florian P.Y.; Paine, Martin R.L.; Flinders, Bryn; Trevitt, Adam J.; Kelly, Patrick D.; Ait-Belkacem, Rima; Garcia, João P.; Creemers, Laura B.; Stauber, Jonathan; Vreeken, Rob J.; Cillero-Pastor, Berta; Ellis, Shane R.; Heeren, Ron M.A. (American Chemical Society, 2019-08-20)
    Visualizing the distributions of drugs and their metabolites is one of the key emerging application areas of matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) within pharmaceutical research. ...
  • Malda, Jos; Groll, Jürgen; van Weeren, P. René (Nature Publishing Group, 2019-10)
    Cartilage has a limited healing capacity; however, studies into the basic biological characteristics, formation and structural maintenance of the cartilage collagen network are providing explanations for the failure of ...
  • Bernal, Paulina Nuñez; Delrot, Paul; Loterie, Damien; Li, Yang; Malda, Jos; Moser, Christophe; Levato, Riccardo (Wiley-VCH Verlag, 2019-10)
    Biofabrication technologies, including stereolithography and extrusion-based printing, are revolutionizing the creation of complex engineered tissues. The current paradigm in bioprinting relies on the additive layer-by-layer ...