The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a large multi-spanning membrane protein that is susceptible to misfolding and aggregation. We have identified here the region responsible for this instability. ...

This article illustrates how the concept of legal mapping opens up new ways of thinking about how the different frameworks of rules and laws that apply in territories under the control of armed groups. It demonstrates how ...

The recently developed compound, tetramethylthiocycloheptyne sulfoximine (TMTHSI), has shown to be a promising strained alkyne for strain-promoted azide–alkyne cycloaddition (SPAAC), metal-free click chemistry. This research ...

Polymeric micelles (PMs) are promising platforms for enhanced tissue targeting of entrapped therapeutic agents. Strategies to circumvent premature release of entrapped drugs include cross-linking of the micellar core as ...

An acute HIV infection in young children differs markedly from that in adults: Children have higher viral loads (VL), and a poor contraction to a setpoint VL that is not much lower than the peak VL. As a result, children ...

T cells recognize pathogens by their highly specific T-cell receptor (TCR), which can bind small fragments of an antigen presented on the Major Histocompatibility Complex (MHC). Antigens that are provided through vaccination ...

Many of the pathways that underlie the diversification of naive T cells into effector and memory subsets, and the maintenance of these populations, remain controversial. In recent years a variety of experimental tools have ...

The COVID-19 pandemic represented a highly dynamic cause of multisystem disturbances that evoked complex and largely differing responses of countries, communities, neighbourhoods, families, schools, and individuals. With ...

Introduction: Before coronavirus disease (covid-19), adolescents from a lower socioeconomic status (SES) background tend to have less positive future orientations, receive less parental support, and have a weaker sense of ...

There is mixed evidence for depression socialization, a process by which friends affect each other’s level of depressive symptoms. The current study examined whether adolescents’ baseline depressive symptoms and three ...