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Utrecht University Repository: Recent submissions

  • Monthly average air pollution models using geographically weighted regression in Europe from 2000 to 2019 
    Shen, Youchen; de Hoogh, Kees; Schmitz, Oliver; Clinton, Nick; Tuxen-Bettman, Karin; Brandt, Jørgen; Christensen, Jesper H; Frohn, Lise M; Geels, Camilla; Karssenberg, Derek; Vermeulen, Roel; Hoek, Gerard (Elsevier bedrijfsinformatie b.v., 2024-03-25)
    Detailed spatial models of monthly air pollution levels at a very fine spatial resolution (25 m) can help facilitate studies to explore critical time-windows of exposure at intermediate term. Seasonal changes in air pollution ...
  • Four governance reforms to strengthen the SDGs 
    Biermann, Frank; Sun, Yixian; Banik, Dan; Beisheim, Marianne; Bloomfield, Michael J.; Charles, Aurelie; Chasek, Pamela; Hickmann, Thomas; Pradhan, Prajal; Sénit, Carole-Anne (American Association for the Advancement of Science, 2023-09-15)
    A demanding policy vision can accelerate global sustainable development efforts In 2015, the United Nations (UN) General Assembly agreed on 17 Sustainable Development Goals (SDGs) with 169 targets as part of the 2030 Agenda ...
  • Effect of Rotavirus Infection and 2′-Fucosyllactose Administration on Rat Intestinal Gene Expression 
    Sáez-Fuertes, Laura; Azagra-Boronat, Ignasi; Massot-Cladera, Malén; Knipping, Karen; Garssen, Johan; Franch, Àngels; Castell, Margarida; Pérez-Cano, Francisco J.; Rodríguez-Lagunas, María J. (MDPI AG, 2023-04)
    Viral infections are described as modifying host gene expression; however, there is limited insight regarding rotavirus (RV) infections. This study aimed to assess the changes in intestinal gene expression after RV infection ...
  • Methodology for biomarker discovery with reproducibility in microbiome data using machine learning 
    Rojas-Velazquez, David; Kidwai, Sarah; Kraneveld, Aletta D.; Tonda, Alberto; Oberski, Daniel; Garssen, Johan; Lopez-Rincon, Alejandro (NLM (Medline), 2024-01-15)
    Background: In recent years, human microbiome studies have received increasing attention as this field is considered a potential source for clinical applications. With the advancements in omics technologies and AI, research ...
  • Gut microbiome studies in CKD: opportunities, pitfalls and therapeutic potential 
    Krukowski, Hubert; Valkenburg, Sophie; Madella, Avra Melina; Garssen, Johan; van Bergenhenegouwen, Jeroen; Overbeek, Saskia Adriana; Huys, Geert R.B.; Raes, Jeroen; Glorieux, Griet (Nature Publishing Group, 2023-02)
    Interest in gut microbiome dysbiosis and its potential association with the development and progression of chronic kidney disease (CKD) has increased substantially in the past 6 years. In parallel, the microbiome field has ...
  • The efficacy of a combination of naproxen and fexofenadine (SJP - 002) to inhibit the symptoms that are associated with viral upper respiratory tract infection: Four case reports of individuals with common cold 
    Išerić, Emina; Dahl, Thomas A; Scholey, Andrew; Iversen, Jacqueline M; Verster, Joris C (John Wiley and Sons Ltd, 2023-07)
    KEY CLINICAL MESSAGE: There is no effective treatment that reduces both the severity and duration of a common cold episode. SJP - 002 (naproxen and fexofenadine) reduced symptom severity by two-third, and the duration of ...
  • Oral immunotherapy as a curative treatment for food-allergic preschool children: Current evidence and potential underlying mechanisms 
    Barten, Lieke J.C.; Zuurveld, Marit; Faber, Joyce; Garssen, Johan; Klok, Ted (Blackwell Munksgaard, 2023-11)
    The worldwide rising prevalence of food allergy is a major public health concern. Standard care consists of allergen avoidance and rescue medication upon accidental exposure. Oral immunotherapy (OIT) is increasingly being ...
  • Raw milk kefir: microbiota, bioactive peptides, and immune modulation 
    Baars, Ton; van Esch, Betty; van Ooijen, Luuk; Zhang, Zuomin; Dekker, Pieter; Boeren, Sjef; Diks, Mara; Garssen, Johan; Hettinga, Kasper; Kort, Remco (Royal Society of Chemistry, 2023-01-24)
    This study aims to characterize the microbiota and peptidomic composition of raw milk kefir, and to address the potential anti-allergic effects of raw milk kefir using validated research models for food allergy. Raw milk ...
  • A probabilistic algorithm for optimising the steady-state diffusional flux into a partially absorbing body 
    Nicolaou, Kyriacos; Mulder, Bela (NLM (Medline), 2023-12-20)
    Cells in an aqueous environment absorb diffusing nutrient molecules through nanoscale protein channels in their outer membranes. Assuming that there are constraints on the number of such channels a cell can produce, we ask ...
  • Healthy people, soils, and ecosystems: uncovering primary drivers in the adoption of regenerative agriculture by US farmers and ranchers 
    Frankel-Goldwater, Lee; Wojtynia, Niko; Dueñas-Ocampo, Sebastián (Frontiers Media S.A., 2024-01-08)
    As regenerative agriculture grows in popularity, policy and decision-makers have become interested in its practices. Yet, little is known about those factors driving its adoption among farmers and ranchers. To better ...
  • On the attractiveness of clothing libraries for women: Investigating the adoption of product-service systems from a practice-based perspective 
    Muylaert, Coralie; Tunn, Vivian S.C.; Maréchal, Kevin (Elsevier BV, 2024-03)
    Clothing libraries, an application of product-service system in the clothing sector, could potentially combat clothing overconsumption but consumer adoption is limited so far. Research so far has largely overlooked the ...
  • Responsible mission governance: An integrative framework and research agenda 
    Wiarda, Martijn; Janssen, Matthijs J.; Coenen, Tom B.J.; Doorn, Neelke (Elsevier bedrijfsinformatie b.v., 2024-03)
    Governance lies at the heart of instigating, steering, and creating the conditions for mission-oriented transitions that potentially help resolve some of our grand societal challenges. In doing so, policymakers will need ...
  • “Locked at the job”: a qualitative study on the process of this phenomenon 
    Feenstra-Verschure, Merel T.; Kooij, Dorien; Freese, Charissa; Van der Velde, Mandy; Lysova, Evgenia I. (Emerald Group Publishing Ltd., 2023-01-31)
    Purpose: Many employees experience a “locked at the job” situation and are not satisfied with their current job and at the same time, perceive limited job opportunities. This study examines the process that individuals who ...
  • Impact of hypoxia and reoxygenation on the extra/intracellular metabolome and on transporter expression in a human kidney proximal tubular cell line 
    Faucher, Quentin; Stéphanie Chadet; Antoine Humeau; Sauvage, François-Ludovic; Arnion, Hélène; Gatault, Philippe; Buchler, Matthias; Roger, Sébastien; Lawson, Roland; Marquet, Pierre; Barin-Le Guellec, Chantal (Springer New York, 2023-09-13)
    Introduction Ischemia-reperfusion injury (IRI) induces several perturbations that alter immediate kidney graft function after transplantation and may affect long-term graft outcomes. Given the IRI-dependent metabolic ...
  • Consistent ecosystem service bundles emerge across global mountain, island and delta systems 
    Oliver Reader, M.; Eppinga, Maarten B.; de Boer, Hugo J.; Petchey, Owen L.; Santos, Maria J. (Elsevier BV, 2024-04)
    Ecosystem services are often analysed individually, but are intertwined with one another and the social-ecological systems they occur in. As a response, ecosystem service bundles, i.e. co-occurring sets of ecosystem services, ...
  • Assessing regime destabilisation through policy change: An analysis of agricultural policy in the United Kingdom during Brexit 
    Frank, Leonard; Feola, Giuseppe; Schäpke, Niko (Elsevier bedrijfsinformatie b.v., 2024-03)
    In sustainability transitions research, the deliberate destabilisation of socio-technical regimes is increasingly recognised as a central intervention point. Absent, however, are granular approaches for assessing whether ...
  • Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches 
    Welsh, Joshua A; Goberdhan, Deborah C I; O'Driscoll, Lorraine; Buzas, Edit I; Blenkiron, Cherie; Bussolati, Benedetta; Cai, Houjian; Di Vizio, Dolores; Driedonks, Tom A P; Erdbrügger, Uta; Falcon-Perez, Juan M; Fu, Qing-Ling; Hill, Andrew F; Lenassi, Metka; Lim, Sai Kiang; Mahoney, Mỹ G; Mohanty, Sujata; Möller, Andreas; Nieuwland, Rienk; Ochiya, Takahiro; Sahoo, Susmita; Torrecilhas, Ana C; Zheng, Lei; Zijlstra, Andries; Abuelreich, Sarah; Bagabas, Reem; Bergese, Paolo; Bridges, Esther M; Brucale, Marco; Burger, Dylan; Carney, Randy P; Cocucci, Emanuele; Colombo, Federico; Crescitelli, Rossella; Hanser, Edveena; Harris, Adrian L; Haughey, Norman J; Hendrix, An; Ivanov, Alexander R; Jovanovic-Talisman, Tijana; Kruh-Garcia, Nicole A; Ku'ulei-Lyn Faustino, Vroniqa; Kyburz, Diego; Lässer, Cecilia; Lennon, Kathleen M; Lötvall, Jan; Maddox, Adam L; Martens-Uzunova, Elena S; Mizenko, Rachel R; Newman, Lauren A; Ridolfi, Andrea; Rohde, Eva; Rojalin, Tatu; Rowland, Andrew; Saftics, Andras; Sandau, Ursula S; Saugstad, Julie A; Shekari, Faezeh; Swift, Simon; Ter-Ovanesyan, Dmitry; Tosar, Juan P; Useckaite, Zivile; Valle, Francesco; Varga, Zoltan; van der Pol, Edwin; van Herwijnen, Martijn J C; Wauben, Marca H M; Wehman, Ann M; Williams, Sarah; Zendrini, Andrea; Zimmerman, Alan J; Misev Consortium; Théry, Clotilde; Witwer, Kenneth W; Stoorvogel, Willem (Co-Action Publishing, 2024-02)
    Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic ...
  • Experimentally-guided in silico design of engineered heart tissues to improve cardiac electrical function after myocardial infarction 
    Rosales, Ricardo M; Mountris, Konstantinos A; Oliván-Viguera, Aida; Pérez-Zabalza, María; Cedillo-Servin, Gerardo; Iglesias-García, Olalla; Hrynevich, Andrei; Castilho, Miguel; Malda, Jos; Prósper, Felipe; Doblaré, Manuel; Mazo, Manuel M; Pueyo, Esther (Elsevier Ltd, 2024-03)
    Engineered heart tissues (EHTs) built from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) showed promising results for cardiac function restoration following myocardial infarction. Nevertheless, ...
  • Physics-based early warning signal shows that AMOC is on tipping course 
    van Westen, René; Kliphuis, Michael; Dijkstra, Henk (American Association for the Advancement of Science, 2024-02-09)
    One of the most prominent climate tipping elements is the Atlantic meridional overturning circulation (AMOC), which can potentially collapse because of the input of fresh water in the North Atlantic. Although AMOC collapses ...
  • An earth system governance research agenda for carbon removal 
    Low, Sean; Boettcher, Miranda; Asayama, Shinichiro; Baum, Chad; Borth, Amanda; Brown, Calum; Clingerman, Forrest; Dauvergne, Peter; De Pryck, Kari; Gupta, Aarti; Honegger, Matthias; Lenzi, Dominic; Reitsma, Renate; Schenuit, Felix; Scott-Buechler, Celina; Valenzuela, Jose Maria (Elsevier BV, 2024-01)
    Carbon dioxide removal (CDR) – the creation, enhancement, and upscaling of carbon sinks – has become a pillar of national and corporate commitments towards Net Zero emissions, as well as pathways towards realizing the Paris ...