Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid-Anchored Peptide Vaccines

DSpace/Manakin Repository

Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid-Anchored Peptide Vaccines
 
Koers, E.J.; López-Deber, M.P.; Weingarth, M.H.; Nand, D.; Hickman, D.T.; Mlaki Ndao, D.; Reis, P.; Granet, A.; Pfeifer, A.; Muhs, A.; Baldus, M.
(2013) Angewandte Chemie-International Edition, volume 52, issue 41, pp. 10905 - 10908
(Article)
Abstract
Sensitivity is the key: Dynamic nuclear polarization NMR spectroscopy provides structural information on liposomal vaccines targeting Alzheimer's disease. DMPC/DMPG/Cholesterol mainly stabilizes extended structures of the lipid-anchored peptide, while in DMTAP/Cholesterol liposomes the peptide adopts a multitude of conformations including random-coil and extended structures.
Download/Full Text
Embargo until January 01 2050
 
DOI: https://doi.org/10.1002/anie.201303374
ISSN: 1433-7851
Publisher: John Wiley and Sons Ltd
(Peer reviewed)
 
 
See more statistics about this item