SIAPhos: Phosphorylated Sulfonimidamides and their Use in Iridium-Catalyzed Asymmetric Hydrogenations of Sterically Hindered Cyclic Enamides

Patureau, F.W.; Worch, C.; Siegler, M.A.M.; Spek, A.L.; Bolm, C.; Reek, J.N.H.

doi:https://doi.org/10.1002/adsc.201100692

SIAPhos: Phosphorylated Sulfonimidamides and their Use in Iridium-Catalyzed Asymmetric Hydrogenations of Sterically Hindered Cyclic Enamides

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SIAPhos: Phosphorylated Sulfonimidamides and their Use in Iridium-Catalyzed Asymmetric Hydrogenations of Sterically Hindered Cyclic Enamides

Patureau, F.W.; Worch, C.; Siegler, M.A.M.; Spek, A.L.; Bolm, C.; Reek, J.N.H.

(2012) Advanced synthesis & catalysis, volume 354, issue 1, pp. 59 - 64

(Article)

Abstract

Phosphorylated sulfonimidamides (SIAPhos) undergo ion exchange reactions with cationic complexes, [Rh(cod)2BF4] and [Ir(cod)2BarF], or neutral complexes [Rh(cod)Cl]2 and [Ir(cod)Cl]2, leading to unprecedented neutral complexes with P-N-S-N chelates. Use of the resulting neutral iridium complexes in asymmetric hydrogenation reactions of tri- and tetrasubstituted enamides leads to products with high enantioselectivities (up ... read more

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DOI: https://doi.org/10.1002/adsc.201100692

ISSN: 1615-4150

Publisher: Wiley-VCH Verlag

(Peer reviewed)

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