Abstract
The yeast Ski complex assists the exosome in the degradation of mRNA. The Ski complex consists of
three components; Ski2, Ski3, and Ski8, believed to be present in a 1:1:1 stoichiometry. Measuring the
mass of intact isolated endogenously expressed Ski complexes by native mass spectrometry we unambiguously
demonstrate that the Ski complex has
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