Abstract
Pheochromocytoma cells (clone PC12)
have specific plasmamembrane receptors
for both epidermal growth factor (EGF)
and nerve growth factor (NGF).
These growth factors have however, opposite
biological effects in PC12 cells;
EGF acts mitogenically, while NGF induces
differentiation and causes arrest
of cell proliferation.
EGF-receptor interaction in PC12
cells was characterized biochemically
by ¹²⁵I-EGF binding studies. EGF binding
was concentration-dependent and
saturable. Scatchard graph
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