A dose-response model for skin cancer induction by chronic u.v. exposure of a human population

Abstract

A dose-response model, based on the results of animal experiments, is presented for skin cancer induction in a human population by chronic exposure to ultraviolet radiation. The model takes into account a variety of exposure habits and susceptibilities of the individuals in the population. The required input data for the dose-response relationship are the age specific incidences of the population in question.

Calculations based on this model can be used as a step in the evaluation of the effect which a reduction of stratospheric ozone would have on the non-melanoma skin cancer incidence. As an example an evaluation for the white population of the U.S.A. is presented. The estimate resulting from this evaluation agrees fairly well with earlier estimates based on combined climatological and epidemiological data.