Abstract
α-melanotropin induces pigment dispersion in
melanophores and pigment formation in melanocytes
and melanoma cells. The pigmentdispersingeffect
of MSH is completely reversible in vitro, as the
melanosomes reaggregate readily upon removal of
the hormone. The primary site of action of α-MSH
appears to be a cell surface receptor, which can be
stimulated by two different portions of the
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