Abstract
Laboratory and experimental data show a dose response curve
for cytostatic drugs, especially for alkylating agents. For many
malignancies, clinical evidence of a dose response relationship
is limited.
The dose limiting toxicity of most cytostatic drugs is myelosuppression,
which can be circumvented by the use of haematopoietic
growth factors and/or autologous hone marrow or
peripheral stem cell
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