Abstract
The N-myc oncogene was first identified as an amplified DNA element
with homology to c-myc in human neuroblastoma. Since this initial
observation, amplification of N-myc has also been observed in other types
of human cancer, predominantly in retinoblastoma and small cell lung
cancer. The apparent role of the N-myc oncogene in neuroblastoma
oncogenesis is unusual
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