Abstract
Hypoxia inducible factor-1 (HIF-1) is an important transcription factor that stimulates tumor growth and metastases via several pathways. Activation of HIF-1 depends on the presence of its a-subunit.
Hypoxia increases HIF-1α levels by inhibiting prolyl-hydroxylasedmediated hydroxylation and thereby preventing proteosome degradation. Various other mechanisms might also contribute to
HIF-1α expression, such as
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