H-1, C-13 and N-15 assignment of the GNA1946 outer membrane lipoprotein from Neisseria meningitidis

Abstract

GNA1946 (Genome-derived Neisseria Antigen 1946) is a highly conserved exposed outer membrane lipoprotein from Neisseria meningitidis bacteria of 287 amino acid length (31 kDa). Although the structure of NMB1946 has been solved recently by X-Ray crystallography, understanding the behaviour of GNA1946 in aqueuos solution is highly relevant for the discovery of the antigenic determinants of the protein that will possibly lead to a more efficient vaccine development against virulent serogroup B strain of N.meningitidis. Here we report almost complete H-1, C-13 and N-15 resonance assignments of GNA1946 (residues 10-287) in aqueous buffer solution.