Abstract
Sir— The model of cancer metastasis
suggested by René Bernards and Robert A.
Weinberg in their Concepts essay (Nature
418, 823; 2002) is, in my view, a tautology.
The suggestion that the same genes are
exclusively responsible both for cancer-cell
metastasis and for the emergence and
proliferation of cancer cells is tantamount
to saying “cancer cells that can
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