Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours

Abstract

Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours Renee GHM van Sprundel1, Ted SGAM van den Ingh2, Valeer J Desmet3, Azeam Katoonizadeh3, Louis C Penning1, Jan Rothuizen1, Tania Roskams3 and Bart Spee13* * Corresponding author: Bart Spee B.Spee@uu.nl Author Affiliations 1 Department of Clinical Sciences of Companion Animals, Faculty of Veterinary medicine, Utrecht University, Utrecht, The Netherlands 2 TCCI Consultancy BV, Utrecht, The Netherlands 3 Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium For all author emails, please log on. Comparative Hepatology 2010, 9:4 doi:10.1186/1476-5926-9-4 The electronic version of this article is the complete one and can be found online at: http://www.comparative-hepatology.com/content/9/1/4 Received: 23 November 2009 Accepted: 18 February 2010 Published: 18 February 2010 © 2010 van Sprundel et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.