Abstract
Regulatory T cells (Tregs) are a specific
subset of lymphocytes that are critical for
the maintenance of self-tolerance. Expression
levels of the transcription factor
Foxp3 have been causally associated with
Treg differentiation and function. Recent
studies show that Foxp3 can also be
transiently expressed in effector T cells;
however, stable Foxp3 expression is required
for development of a functional
Treg
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