Regional concentrations of noradrenaline and dopamine in the frontal cortex of the rat: dopaminergic innervation of the prefrontal subareas and lateralization of prefrontal dopamine

Abstract

Catecholamine levels in the two subareas of the prefrontal cortex and in one non-prefrontal region of the rat frontal lobe were measured radioenzymatically. In contrast with noradrenaline (NA), the distribution of dopamine (DA) in the frontal lobe is markedly heterogeneous. DA levels of the orbitofrontal and medial prefrontal subarea are, respectively, 3 and 4 times higher than those of a non-prefrontal region of the frontal lobe, confirming the expectation of neuroanatomical findings. Furthermore, it appears that at the population level, DA levels of the medial prefrontal subarea are lateralized, the left hemisphere being significantly higher than the right hemisphere.