Peritoneal biology during laparoscopic surgery

Abstract

The minimal invasive character of laparoscopic surgery may reduce surgical trauma to the peritoneum. Laparoscopic procedures, however, introduce novel entities in the abdominal cavity, which all may affect peritoneal integrity and biology. The studies, described in this theses were conducted to study the effects of laparoscopic surgery on the peritoneal fibrinolytic response. Moreover, the possible effects of illumination, increased intra-abdominal pressure and the choice of dissection device were studied as were the consequences of intra-peritoneal temperature shifts. Additionally, the hypothesis that peritoneal TGF-beta 1 expression could be affected by laparoscopic surgical techniques was tested. Finally, the peritoneal fibrinolytic response to both conventional and laparoscopic colonic surgery was clarified