Abstract
genesPAI-1PI(3)KPKBGSK3cyclin D1p19ARFp21CIP1uPAp16INK4Acyclin EPCNAp53 limits the proliferation of primary diploid fibroblasts by inducing a state of growth arrest named replicative senescence — a process which protects against oncogenic transformation and requires integrity of the p53 tumour suppressor pathway1, 2, 3. However, little is known about the downstream target genes of p53
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