The influence of glucose 1,6-diphosphate on the enzymatic activity of pyruvate kinase

Abstract

1. 1. The influence of Glc-1,6-P2 on hepatic and red blood cell pyruvate kinase (ATP: pyruvate phosphotransferase, EC 2.7.1.40) is quite similar to that of Fru-1,6-P2. The hexose diphosphates can replace each other in stimulating pyruvate kinase; after maximal stimulation by one of the compounds, the other is not capable of further stimulation.

2. 2. The regulatory role of Fru-1,6-P2 on the activity of pyruvate kinase is discussed in view of the results obtained.