The effect of rifampicin on the replication of the replicative form of bacteriophage ΦX174 DNA

Abstract

The effect of inhibition of RNA synthesis by the antibiotic rifampicin on the replication of the double-stranded replicative form (RF) of ΦX174 DNA has been studied. Inhibition of RNA synthesis shortly after the onset of RF replication is severely inhibitory; inhibition of RNA synthesis at later times allows RF replication to proceed at a normal rate for a considerable time.