Effet d'un régime pauvre en magnésium sur la toxicité de l'histamine chez le rat

Abstract

The lethality of histamine was studied in two groups of young rats fed diets low and normal in magnesium content. The plasma magnesium levels of the two groups on the eight day were 0.39 mg/100 ml for the rats on the low magnesium diet and 2.11 mg/100 ml for the group on the normal diet. The LD50's (and the 95 per cent confidence limits) for both groups for histamine administered intravenously were 412 (349–486) and 530 (449–625) mg histamine computed as free base/kg body weight, respectively (p < 0.05). The data indicate that a reduction in total body magnesium enhances the toxic effects of histamine in this species.