Analysis of the primary structure of P-fimbrillins of uropathogenic Escherichia coli

Abstract

The ability of uropathogenic Escherichia coli to adhere to uroepithelial cells is a prerequisite for successful colonization of the urinary tract by this organism, and the subsequent development of urinary tract infections. The mechanism of adherence has been studied intensively during the last years . Many investigators support the view that P-fimbriae play an important role in this adhesion process. P-fimbriae recognize a disaccharide with the structure α-D-Galp β-D-Galp in the uroepithelium. This structure is also part of the P-bloodgroup antigen . Adherence of p-fimbriated cells to the P blood group antigen on the surface of human erytrocytes causes mannose resistant hemagglutination (MRHA) .