Evaluation of the detection rate of hemophilia carriers

Abstract

The detection rate of hemophilia A carriers was evaluated on the basis of AHF-activity and AHF-like antigen determination. Statistical tolerance regions were constructed containing 50 and 95% of the AHF-activity and AHF-like antigen determinations of individuals of the normal or carrier group. Using these regions 18 out of 22 obligatory carriers are outside the 95% tolerance region of the normals. On the basis of AHF-activity alone only 8 out of 22 obligatory carriers are outside the 95% tolerance interval for the normals.

For individual counselling for possible or potential carriers, with a prior chance (i.e. genetically determined) on carriership, the probabilities of carriership are calculated with the theorem of Bayes.