Disbalance of immunoglobulins the clinical importance of increased serum levels of immunoglobulin-A and -G in combination with normal or diminished immunoglobulin-M concentrations

Abstract

A disbalance of immunoglobulin-A (IgA), immunoglobulin-G (IgG) and immunoglobulin-M (IgM) concentrations—i.e., increased IgA and IgG fractions and a normal or diminished IgM concentration—is not a specific finding but one that frequently occurs in collagen diseases which take a chronic course. In the series studied, no correlation was demonstrable between this disbalance and the results of serological tests for rheumatic disease.