Abstract
The c-myc gene encodes a sequence-specific DNA binding
protein that activates transcription of cellular
genes. Transcription activation by Myc proteins is regulated
by phosphorylation of serine and threonine residues
within the transactivation domain and by complex
formation with the retinoblastoma-related protein p107.
In Burkitt’s lymphoma, missense mutations within the
c-Myc transactivation domain have been found with
high frequency.
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