Body mass index, waist circumference and waist–hip ratio and serum levels of IGF-I and IGFBP-3 in European women
Gram, I.T.; Norat, T.; Rinaldi, S.; Dossus, L.; Lukanova, A.; Tehard, B.; Clavel-Chapelon, F.; Gils, C.H. van; Noord, P.A.H. van; Peeters, P.H.M.; Bueno-de-Mesquita, H.B.; Nagel, G.; Linseisen, J.; Lahmann, P.H.; Boeing, H.; Palli, D.; Sacerdote, C.; Panico, S.; Tumino, R.; Sieri, S.; Dorronsoro, M.; Quirós, J.R.; Navarro, C.A.; Barricarte, A.; Tormo, M.J.; Gonzalez, C.A.; Overvad, K.; Paaske Johnsen, S.; Olsen, A.; Tjønneland, A.; Travis, R.; Allen, N.; Bingham, S.; Khaw, K-T.; Stattin, P.; Trichopoulou, A.; Kalapothaki, V.; Psaltopoulou, T.; Casagrande, C.; Riboli, E.; Kaaks, R.
(2006) International Journal of Obesity, pp. 1 - 9
(Article)
Abstract
Objective: To examine the relationship between body mass index (BMI) and waist–hip ratio (WHR) with serum levels of insulinlike
growth factor-I (IGF-I), and its binding protein (IGFBP)-3.
Design: Cross-sectional study on 2139 women participating in a case–control study on breast cancer and endogenous
hormones. Data on lifestyle and reproductive factors were collected by
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means of questionnaires. Body height, weight, waist and
hip circumferences were measured. Serum levels of IGF-I and insulin-like binding protein (IGFBP)-3 were measured by enzymelinked
immunosorbent assays. Adjusted mean levels of IGF-I and IGFBP-3 across quintiles of BMI, waist circumference, and WHR
were calculated by linear regression. Results were adjusted for potential confounders associated with IGF-I and IGFBP-3.
Results: Adjusted mean serum IGF-I values were lower in women with BMIo22.5 kg/m2 or BMI429.2 kg/m2 compared to
women with BMI within this range (Pheterogeneityo0.0001, Ptrend¼0.35). Insulin-like growth factor-I was not related to WHR after
adjustment for BMI. IGF-binding protein-3 was linearly positively related to waist and WHR after mutual adjustment. The molar
ratio IGF-I/IGFBP-3 had a non-linear relation with BMI and a linear inverse relationship with WHR (Ptrend¼0.005).
Conclusions: Our data confirm the nonlinear relationship of circulating IGF-I to total adiposity in women. Serum IGFBP-3 was
positively related to central adiposity. These suggest that bioavailable IGF-I levels could be lower in obese compared to nonobese
women and inversely related to central adiposity.
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Keywords: IGF-I, IGFBP-3, body mass index, waist–hip ratio, women
Publisher: Nature Publishing Group