Abstract
The small GTPase Rap1 is highly expressed in human neutrophils,
but its function is largely unknown. Using the Rap1-
binding domain of RalGDS (RalGDS-RBD) as an activationspecific
probe for Rap1, we have investigated the regulation
of Rap1 activity in primary human neutrophils. We found
that a variety of stimuli involved in neutrophil activation,
including fMet-Leu-Phe (fMLP),
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