Modulation of exocytosis by exogenous and endogenous factors

Abstract

Intercellular communication is initiated by the release of neurotransmitters from the presynaptic nerve cell, i.e. exocytosis. Therefore, the strength of the presynaptic signal is determined by the type of neurotransmitter released, the number of neurotransmittercontaining vesicles that fuse and the amount of neurotransmitter released per vesicle. Consequently, modulation of the presynaptic signal plays a crucial role in neurotransmission and, therefore, is of vital importance.