Abstract
Eosinophil-derived neurotoxin (EDN) found in the granules
of human eosinophils is a cationic ribonuclease toxin. Expression
of the EDN gene (RNS2) in eosinophils is dependent on
proximal promoter sequences in combination with an enhancer
located in the first intron. We further define here the
active region of the intron using transfections in differentiated
eosinophilic HL60 cells.
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