Abstract
Although it is known that many stimuli can activate mitogen-
activated protein kinases (MAPKs) and phosphatidylinositol 3-
kinases (PI3K) in human neutrophils, little is known concerning
either the mechanisms or function of this activation. We have
utilized a selective inhibitor of MAPKkinase (MEK), PD098059,
and two inhibitors of PI3K, wortmannin and LY294002, to
investigate the roles
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